MZRA_ECOLI » Modulator protein MzrA

MZRA_ECOLI » Modulator protein MzrA
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Topology in Bacterial Gram-negative inner membrane
Topologyextracellular side
cytoplasmic side
MZRA_ECOLI » Modulator protein MzrA »
Hydrophobic Thickness 30.0 ± 3.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -34.6 kcal/mol
ΔGfold -15.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 10-31 (8-36)
Pathways none
PDB none
OPM none
Complexes

MZRA:MZRA_KLEP7

Interactions

MZRA, Complex: Homodimer of modulator protein MzrA, PDBID: 4PWU

Domains

AA: 9-105, PDBID: 4PWU, Subunit C, Seq Identity:63%, SecD export protein N-terminal TM region

UniProt annotation for MZRA_ECOLI » Modulator protein MzrA
FUNCTION: Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. Links the two-component systems CpxA/CpxR and EnvZ/OmpR.

SUBUNIT: Interacts with EnvZ.

INDUCTION: Regulated by the CpxA/CpxR two-component system. Negatively regulated by EnvZ/OmpR.

DOMAIN: Interacts with EnvZ through its soluble periplasmic region.

UniProt features for MZRA_ECOLI » Modulator protein MzrA
CHAIN 1 127 Modulator protein MzrA.
Amino Acid Sequence for MZRA_ECOLI » Modulator protein MzrA
MQIPRMSLRQ LAWSGAVLLL VGTLLLAWSA VRQQESTLAI RAVHQGTTMP DGFSIWHHLD AHGIPFKSIT PKNDTLLITF DSSDQSAAAK AVLDRTLPHG YIIAQQDNNS QAMQWLTRLR DNSHRFG