MUCEN_HUMAN » Endomucin

MUCEN_HUMAN » Endomucin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MUCEN_HUMAN » Endomucin » Endomucin-2;Gastric cancer antigen Ga34;Mucin-14;MUC-14;
Hydrophobic Thickness 39.2 ± 4.0 Å
Tilt Angle 1 ± 1°
ΔGtransfer -32.1 kcal/mol
ΔGfold -23.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 188-215 (183-215)
Pathways none
PDB none
OPM none
Complexes none
Interactions

LYAM1, Complex: LYAM1:MUCEN, PubMed

Domains

AA: 1-261, Endomucin

UniProt annotation for MUCEN_HUMAN » Endomucin
FUNCTION: Endothelial sialomucin, also called endomucin or mucin- like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.

TISSUE SPECIFICITY: Expressed in heart, kidney and lung.

UniProt features for MUCEN_HUMAN » Endomucin
SIGNAL 1 18 Potential.
CHAIN 19 261 Endomucin.
Amino Acid Sequence for MUCEN_HUMAN » Endomucin
MELLQVTILF LLPSICSSNS TGVLEAANNS LVVTTTKPSI TTPNTESLQK NVVTPTTGTT PKGTITNELL KMSLMSTATF LTSKDEGLKA TTTDVRKNDS IISNVTVTSV TLPNAVSTLQ SSKPKTETQS SIKTTEIPGS VLQPDASPSK TGTLTSIPVT IPENTSQSQV IGTEGGKNAS TSATSRSYSS IILPVVIALI VITLSVFVLV GLYRMCWKAD PGTPENGNDQ PQSDKESVKL LTVKTISHES GEHSAQGKTK N