MUC3B_HUMAN » Mucin-3B

MUC3B_HUMAN » Mucin-3B
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
MUC3B_HUMAN » Mucin-3B » MUC-3B; Intestinal mucin-3B;
Hydrophobic Thickness 30.0 ± 2.4 Å
Tilt Angle 1 ± 3°
ΔGtransfer -36.0 kcal/mol
ΔGfold -17.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1141-1162 (1136-1166)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 597-701, SEA domain

UniProt annotation for MUC3B_HUMAN » Mucin-3B
FUNCTION: Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity).

TISSUE SPECIFICITY: Fetal and adult small intestine and fetal and adult colon.

UniProt features for MUC3B_HUMAN » Mucin-3B
CHAIN <1 901 Mucin-3B.
DOMAIN 554 587 EGF-like.
DOMAIN 596 716 SEA.
DISULFID 558 564 By similarity.
DISULFID 577 586 By similarity.
Amino Acid Sequence for MUC3B_HUMAN » Mucin-3B
MQLLGLLSIL WMLKSSPGAT GTLSTATSTS HVTFPRAEAT RTALSNSPHS RYLAEWPQGV PQLASPAPGH RENAPMTLTT SPHDTLISET LLSSLVSSNT STTPTSKFAF KVETTPPTVL VYSATTECVY PTSFIITISH STSICVTTTQ VTFTSSYTPT PVTQKPVTTV TRTYPMTTTE KGTSAMISSP STTTARETPI VTVTPSSSVS ATDTTFHTTI SSTTRTTERT PLPTGSIHTT MSPTPVFTTL KTAVTSTSPI TSTITSTNTV TSMTTTTSRP TATNTLSSLT SSILSSTPAP NTEVITSHTT TTTPPSTLVT TLPTAIARST PTSETTPSFM SSIITTETTS HSTPSFSSST IHSTVSSSTT AITSPFTTAE TGVTSTPSSP SSLSTDIPTT SLRTLTPLSL STSTSLTTTT DLPSIPTDIS SLPTPIHIIS SSPSIQSTET SSLVGTTSPT MSTVRATLRS TENTPISSFS TSIVVTPETP TTQAPPVLMS ATGTQTSPVP TTVTFGSMDS STSTLHTLTP STALSKIMST SQFPIPSTHS STLQTTPSIP SLQTSLTSTS EFTTESFTRG STSTNAILTS FSTIIWSSTP TIIMSSSPSS ASITPVFATT IHSVPSSPYI FSTENVGSAS ITAFPSLSSS STTSTSPTSS SLTTALTEIT PFSYISLPST TPCPGTITIT IVPASPTDPC VEMDPSTEAT SPPTTPLTVF PFTTEMVTCP SSISMQTTLA THMDTSSMTP ESESSIIPNA SSSTGTGTVP TNTVFTSTRL PTSETWLSNN SVIPTPLPGV STIPLTMKPS SSLPTILRTS SKSTHPSPPT ARTSQTSVAT TQTPTTLTTC RTTPITSWMT TQSTLTTTAG TCDNGGTWEQ GQCACLPGFS GDRCQLQTRC QNGGQWDGLK CQCPSTFYGS SCEFAVEQVD LDVVETEVGM EVSVDQQFSP DLNDNTSQAY RDFNKTFWNQ MQKIFADMQG FTFKGVEILS LRNGSIVVDY LVLLEMPFSP QLESEYEQVK TTLKEGLQNA SQDANSCQDS QALCFKPDSI KVNNNSKTEL TPEAICRRAA PTGYEEFYFP LVEATRLRCV TKCTSGLDNA IDCHQGQCVL ETSGPACRCY STDTHWFSGP RCEVTVHWRA LVGGLTAGAA LLVLLLLALG VRAVRSEWWG RQRRGRSWDQ DRKWFETWDE EVVGTFSNWG FEDDGTDKDT NFHVALENVD TTMKVHIKRP EMTSSSV