MUC3A_HUMAN » Mucin-3A

MUC3A_HUMAN » Mucin-3A
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MUC3A_HUMAN » Mucin-3A » MUC-3A; Intestinal mucin-3A;
Hydrophobic Thickness 27.2 ± 3.2 Å
Tilt Angle 0 ± 1°
ΔGtransfer -33.0 kcal/mol
ΔGfold -17.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 2444-2468 (2437-2470)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 2240-2341, PDBID: 2ACM, Subunit A, Seq Identity:19%, SEA domain

UniProt annotation for MUC3A_HUMAN » Mucin-3A
FUNCTION: Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.

TISSUE SPECIFICITY: Broad specificity; small intestine, colon, colonic tumors, heart, liver, thymus, prostate, pancreas and gall bladder.

UniProt features for MUC3A_HUMAN » Mucin-3A
SIGNAL 1 21 Potential.
CHAIN 22 2541 Mucin-3A.
REPEAT 1325 1341 1.
REPEAT 1342 1358 2.
REPEAT 1359 1375 3.
REPEAT 1376 1392 4.
REPEAT 1393 1409 5.
REPEAT 1410 1426 6.
REPEAT 1427 1443 7.
REPEAT 1444 1460 8.
REPEAT 1461 1477 9.
REPEAT 1478 1494 10.
REPEAT 1495 1511 11.
REPEAT 1512 1528 12.
REPEAT 1529 1545 13.
REPEAT 1546 1562 14.
REPEAT 1563 1579 15.
REPEAT 1580 1596 16.
REPEAT 1597 1613 17.
REPEAT 1614 1630 18.
REPEAT 1631 1647 19.
REPEAT 1648 1664 20.
DOMAIN 2194 2227 EGF-like.
DOMAIN 2236 2356 SEA.
REGION 1325 1664 17 X approximate tandem repeats, Ser/Thr- rich.
DISULFID 2198 2204 By similarity.
DISULFID 2217 2226 By similarity.
Amino Acid Sequence for MUC3A_HUMAN » Mucin-3A
MQLLGLLGLL WMLKASPWAT GTLSTATSIS QVPFPRAEAA SAVLSNSPHS RDLAGWPLGV PQLASPAPGH RENAPMTLTT SPHDTLISET LLNSPVSSNT STTPTSKFAF KVETTPPTVL VYSATTECVY PTSFIITISH PTSICVTTTQ VAFTSSYTST PVTQKPVTTV TSTYSMTTTE KGTSAMTSSP STTTARETPI VTVTPSSVSA TDTTFHTTIS STTRTTERTP LPTGSIHTTT SPTPVFTTLK TAVTSTSPIT SSITSTNTVT SMTTTASQPT ATNTLSSPTR TILSSTPVLS TETITSGITN TTPLSTLVTT LPTTISRSTP TSETTYPTSP XXXXXXXXXX AMTSPPPVSS SITPTNTMTS MRTTTYWPTA TNTLSPLTSS ILSSTPVPST EMITSHTTNT TPLSTLVTTL LTTITRSTPT SETTYPTSPT SIVSDSTTEI TYSTSITGTL STATTLPPTS SSLPTTETAT MTPTTTLITT TPNTTSHSTP SFTSSTIYST VSTSTTAISS ASPTSGTMVT STTMTPSSLS TDTPSTTPTT ITYPSVGSTG FLTTATDLTS TFTVSSSSAM SKSVIPSSPS IQNTETSSLV SMTSATTPSL RPTITSTDST LTSSLLTTFP STYSFSSSMS ASSAGTTHTE TISSLPASTN TIHTTAESAL APTTTTSFTT SPTMEPPSTT VATTGTGQTT FPSSTATFLE TTTLTPTTDF STESLTTAMT STPPITSSIT PTDTMTSMRT TTSWPTATNT LSPLTSSILS STPVPSTEVT TSHTTNTNPV STLVTTLPIT ITRSTLTSET AYPSSPTSTV TESTTEITYP TTMTETSSTA TSLPPTSSLV STAETAKTPT TNLXXXXXXX XXXFTSSTSL LHSQHTTXLP SPSVPTTLGT MVTSTSXIPS SLSTDIPTSQ PTTITPSSVG ITGSLPMMTD LTSVYTVSSM SARPTSVIPS SPTVQNTETS IFVSMMSATT PSGGSTFTST ENTPTRSLLT SFPVTHSFSS SMSASSVGTT HTQSISSPPA ITSTLHTTAE STPSPTTTMS FTTFTKMETP SSTVATTGTG QTTFTSSTAT SPKTTTLTPT SDISTGSFKT AVSSTPPITS SITSTYTVTS MTTTTPLGPT ATNTLPSFTS SVSSSTPVPS TEAITSGTTN TTPLSTLVTT FSNSDTSSTP TSETTYPTSL TSALTDSTTR TTYSTNMTGT LSTVTSLRPT SSSLLTTVTA TVPTTNLVTT TTKITSHSTP SFTSSIATTE TPSHSTPRFT SSITTTETPS HSTPRFTSSI TNTKTTSHSS PSFTSSITTT DSIVXXXXXX XXXXITITET TSHSTPSYTT SITTTETPSH STPSYTTSIT TTETPSHSTP SFTSSITTTE TTSHSTPSFT SSIRTTETTS YSTPSFTSSN TITETTSHST PSYITSITTT ETPSSSTPSF SSSITTTEIS SHSTPSFSSS TIYSTVTSHS TPRFTSSITT TETPSHSTPR FTSSFTNTKT TSHRSPSFTS LITTTETTSH STPSFTSSIT TTETTSHSAR SFTSSITTTE TTSHNTRSFT SSITTTETNS HSTTSFTSSI TTTETTSHST PSFSSSITTT ETPLHSTPGL TSWVTTTKTT SHITPGLTSS ITTTETTSHS TPGFTSSITT TETTSESTPS LSSSTIYSTV STSTTAITSH FTTSETAVTP TPVTPSSLST DIPTTSLRTL TPSSVGTSTS LTTTTDFPSI PTDISTLPTR THIISSSPSI QSTETSSLVG TTSPTMSTVR MTLRITENTP ISSFSTSIVV IPETPTQTPP VLTSATGTQT SPAPTTVTFG STDSSTSTLH TLTPSTALST IVSTSQVPIP STHSSTLQTT PSTPSLQTSL TSTSEFTTES FTRGSTSTNA ILTSFSTIIW SSTPTIIMSS SPSSASITPV FSTTIHSVPS SPYIFSTENV GSASITGFPS LSSSATTSTS STSSSLTTAL TEITPFSYIS LPSTTPCPGT ITITIVPASP TDPCVEMDPS TEATSPPTTP LTVFPFTTEM VTCPTSISIQ TTLTTYMDTS SMMPESESSI SPNASSSTGT GTVPTNTVFT STRLPTSETW LSNSSVIPLP LPGVSTIPLT MKPSSSLPTI LRTSSKSTHP SPPTTRTSET PVATTQTPTT LTSRRTTRIT SQMTTQSTLT TTAGTCDNGG TWEQGQCACL PGFSGDRCQL QTRCQNGGQW DGLKCQCPST FYGSSCEFAV EQVDLDVVET EVGMEVSVDQ QFSPDLNDNT SQAYRDFNKT FWNQMQKIFA DMQGFTFKGV EILSLRNGSI VVDYLVLLEM PFSPQLESEY EQVKTTLKEG LQNASQDANS CQDSQTLCFK PDSIKVNNNS KTELTPEAIC RRAAPTGYEE FYFPLVEATR LRCVTKCTSG VDNAIDCHQG QCVLETSGPA CRCYSTDTHW FSGPRCEVAV HWRALVGGLT AGAALLVLLL LALGVRAVRS GWWGGQRRGR SWDQDRKWFE TWDEEVVGTF SNWGFEDDGT DKDTNFHVAL ENVDTTMKVH IKRPEMTSSS V