MUC24_HUMAN » Sialomucin core protein 24

MUC24_HUMAN » Sialomucin core protein 24
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Topology in Lysosomal membrane
Topologylysosome lumenal side
cytoplasmic side
MUC24_HUMAN » Sialomucin core protein 24 » MUC-24; Endolyn;Multi-glycosylated core protein 24;MGC-24; MGC-24v;
Hydrophobic Thickness 34.8 ± 1.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -42.6 kcal/mol
ΔGfold -17.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 162-187 (162-191)
Pathways

Lysosome (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 60-197, Multi-glycosylated core protein 24 (MGC-24), sialomucin

UniProt annotation for MUC24_HUMAN » Sialomucin core protein 24
FUNCTION: Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).

SUBUNIT: Homodimer (isoform 4). Interacts with CXCR4.

TISSUE SPECIFICITY: Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells.

INDUCTION: Up-regulated by CXCL12 in prostate cancer cell lines.

UniProt features for MUC24_HUMAN » Sialomucin core protein 24
SIGNAL 1 23 Potential.
CHAIN 24 197 Sialomucin core protein 24.
REGION 191 197 Required for endosomal and lysosomal localization (By similarity).
Amino Acid Sequence for MUC24_HUMAN » Sialomucin core protein 24
MSRLSRSLLW AATCLGVLCV LSADKNTTQH PNVTTLAPIS NVTSAPVTSL PLVTTPAPET CEGRNSCVSC FNVSVVNTTC FWIECKDESY CSHNSTVSDC QVGNTTDFCS VSTATPVPTA NSTAKPTVQP SPSTTSKTVT TSGTTNNTVT PTSQPVRKST FDAASFIGGI VLVLGVQAVI FFLYKFCKSK ERNYHTL