MUC21_HUMAN » Mucin-21

MUC21_HUMAN » Mucin-21
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MUC21_HUMAN » Mucin-21 » MUC-21; Epiglycanin;
Hydrophobic Thickness 34.0 ± 2.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -44.5 kcal/mol
ΔGfold -20.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 477-502 (477-503)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 18-83, Tandem-repeating region of mucin, epiglycanin-like

AA: 76-136, Tandem-repeating region of mucin, epiglycanin-like

AA: 124-182, Tandem-repeating region of mucin, epiglycanin-like

AA: 168-227, Tandem-repeating region of mucin, epiglycanin-like

AA: 213-275, Tandem-repeating region of mucin, epiglycanin-like

AA: 271-337, Tandem-repeating region of mucin, epiglycanin-like

AA: 331-398, Tandem-repeating region of mucin, epiglycanin-like

AA: 391-458, Tandem-repeating region of mucin, epiglycanin-like

AA: 463-564, Mucin, catalytic, TM and cytoplasmic tail region

UniProt annotation for MUC21_HUMAN » Mucin-21
TISSUE SPECIFICITY: Expressed in lung, large intestine, thymus, and testis. Expressed in normal and malignant bronchial epithelial cells.

MISCELLANEOUS: Could be considered as a marker for lung carcinomas.

UniProt features for MUC21_HUMAN » Mucin-21
SIGNAL 1 24 Potential.
CHAIN 25 566 Mucin-21.
REPEAT 31 44 1.
REPEAT 45 59 2.
REPEAT 60 74 3.
REPEAT 75 89 4.
REPEAT 90 104 5.
REPEAT 105 119 6.
REPEAT 120 134 7.
REPEAT 135 149 8.
REPEAT 150 164 9.
REPEAT 165 179 10.
REPEAT 180 194 11.
REPEAT 195 209 12.
REPEAT 210 224 13.
REPEAT 225 239 14.
REPEAT 244 254 15.
REPEAT 255 269 16.
REPEAT 270 284 17.
REPEAT 285 299 18.
REPEAT 300 314 19.
REPEAT 315 329 20.
REPEAT 330 344 21.
REPEAT 345 359 22.
REPEAT 360 374 23.
REPEAT 375 389 24.
REPEAT 390 404 25.
REPEAT 405 419 26.
REPEAT 420 434 27.
REPEAT 435 449 28.
REGION 31 435 28 X 15 AA approximate tandem repeats.
REGION 521 566 Cytoplasmic tail.
SITE 502 503 Cleavage (Potential).
Amino Acid Sequence for MUC21_HUMAN » Mucin-21
MKMQKGNVLL MFGLLLHLEA ATNSNETSTS ANTGSSVISS GASTATNSGS SVTSSGVSTA TISGSSVTSN GVSIVTNSEF HTTSSGISTA TNSEFSTASS GISIATNSES STTSSGASTA TNSESSTPSS GASTATNSDS STTSSGASTA TNSDSSTTSS EASTATNSES STTSSGASTA TNSESSTVSS RASTATNSES STTSSGASTA TNSESRTTSN GAGTATNSES STTSSGASTA TNSESSTPSS GAGTATNSES STTSSGAGTA TNSESSTVSS GISTVTNSES STPSSGANTA TNSESSTTSS GANTATNSDS STTSSGASTA TNSESSTTSS GASTATNSES STTSSGASTA TNSGSSTTSS GTSTATNSES STVSSGASTA TTSESSTTSS GASTATNSES STVSSGASTA TNSESSTTSS GANTATNSGS SVTSAGSGTA ALTGMHTTSH SASTAVSEAK PGGSLVPWEI FLITLVSVVA AVGLFAGLFF CVRNSLSLRN TFNTAVYHPH GLNHGLGPGP GGNHGAPHRP RWSPNWFWRR PVSSIAMEMS GRNSGP