MUC18_HUMAN » Cell surface glycoprotein MUC18

MUC18_HUMAN » Cell surface glycoprotein MUC18
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MUC18_HUMAN » Cell surface glycoprotein MUC18 » Cell surface glycoprotein P1H12;Melanoma cell adhesion molecule;Melanoma-associated antigen A32;Melanoma-associated antigen MUC18;S-endo 1 endothelial-associated antigen;
Hydrophobic Thickness 34.4 ± 3.2 Å
Tilt Angle 41 ± 0°
ΔGtransfer -29.9 kcal/mol
ΔGfold -25.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 555-583 (555-585)
Pathways none
PDB none
OPM none
Complexes none
Interactions

LYAM2, Complex: MUC18:LYAM2, PubMed

Domains

AA: 30-133, PDBID: 4H5S, Subunit B, Seq Identity:25%, Immunoglobulin V-set domain

AA: 139-234, PDBID: 2PET, Subunit A, Seq Identity:36%, CD80-like C2-set immunoglobulin domain

AA: 253-322, PDBID: 1L6Z, Subunit A, Seq Identity:30%, Immunoglobulin domain

AA: 348-421, PDBID: 1N26, Subunit A, Seq Identity:30%, Immunoglobulin domain

UniProt annotation for MUC18_HUMAN » Cell surface glycoprotein MUC18
FUNCTION: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

TISSUE SPECIFICITY: Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.

UniProt features for MUC18_HUMAN » Cell surface glycoprotein MUC18
SIGNAL 1 23
CHAIN 24 646 Cell surface glycoprotein MUC18.
DOMAIN 24 129 Ig-like V-type 1.
DOMAIN 139 242 Ig-like V-type 2.
DOMAIN 244 330 Ig-like C2-type 1.
DOMAIN 335 424 Ig-like C2-type 2.
DOMAIN 430 510 Ig-like C2-type 3.
DISULFID 48 116 Probable.
DISULFID 161 223 Probable.
DISULFID 272 320 Probable.
DISULFID 365 407 Probable.
DISULFID 452 499 Probable.
Amino Acid Sequence for MUC18_HUMAN » Cell surface glycoprotein MUC18
MGLPRLVCAF LLAACCCCPR VAGVPGEAEQ PAPELVEVEV GSTALLKCGL SQSQGNLSHV DWFSVHKEKR TLIFRVRQGQ GQSEPGEYEQ RLSLQDRGAT LALTQVTPQD ERIFLCQGKR PRSQEYRIQL RVYKAPEEPN IQVNPLGIPV NSKEPEEVAT CVGRNGYPIP QVIWYKNGRP LKEEKNRVHI QSSQTVESSG LYTLQSILKA QLVKEDKDAQ FYCELNYRLP SGNHMKESRE VTVPVFYPTE KVWLEVEPVG MLKEGDRVEI RCLADGNPPP HFSISKQNPS TREAEEETTN DNGVLVLEPA RKEHSGRYEC QGLDLDTMIS LLSEPQELLV NYVSDVRVSP AAPERQEGSS LTLTCEAESS QDLEFQWLRE ETGQVLERGP VLQLHDLKRE AGGGYRCVAS VPSIPGLNRT QLVNVAIFGP PWMAFKERKV WVKENMVLNL SCEASGHPRP TISWNVNGTA SEQDQDPQRV LSTLNVLVTP ELLETGVECT ASNDLGKNTS ILFLELVNLT TLTPDSNTTT GLSTSTASPH TRANSTSTER KLPEPESRGV VIVAVIVCIL VLAVLGAVLY FLYKKGKLPC RRSGKQEITL PPSRKSELVV EVKSDKLPEE MGLLQGSSGD KRAPGDQGEK YIDLRH