MUC17_HUMAN » Mucin-17

MUC17_HUMAN » Mucin-17
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MUC17_HUMAN » Mucin-17 » MUC-17; Small intestinal mucin-3;MUC-3;
Hydrophobic Thickness 35.6 ± 2.6 Å
Tilt Angle 29 ± 0°
ΔGtransfer -33.2 kcal/mol
ΔGfold -25.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 4390-4415 (4384-4419)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 4186-4288, PDBID: 2ACM, Subunit A, Seq Identity:21%, SEA domain

UniProt annotation for MUC17_HUMAN » Mucin-17
FUNCTION: Probably plays a role in maintaining homeostasis on mucosal surfaces.

SUBUNIT: Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.

TISSUE SPECIFICITY: Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers.

UniProt features for MUC17_HUMAN » Mucin-17
SIGNAL 1 25 Potential.
CHAIN 26 4493 Mucin-17.
REPEAT 185 245 1.
REPEAT 246 300 2.
REPEAT 301 361 3.
REPEAT 362 418 4.
REPEAT 420 477 5.
REPEAT 479 538 6.
REPEAT 539 597 7.
REPEAT 598 654 8.
REPEAT 656 715 9.
REPEAT 716 774 10.
REPEAT 775 831 11.
REPEAT 833 892 12.
REPEAT 893 951 13.
REPEAT 952 1010 14.
REPEAT 1011 1069 15.
REPEAT 1070 1121 16.
REPEAT 1122 1187 17.
REPEAT 1188 1246 18.
REPEAT 1247 1305 19.
REPEAT 1306 1364 20.
REPEAT 1365 1423 21.
REPEAT 1424 1482 22.
REPEAT 1483 1541 23.
REPEAT 1542 1600 24.
REPEAT 1601 1656 25.
REPEAT 1658 1717 26.
REPEAT 1718 1776 27.
REPEAT 1777 1835 28.
REPEAT 1836 1895 29.
REPEAT 1896 1951 30.
REPEAT 1953 2012 31.
REPEAT 2013 2071 32.
REPEAT 2072 2127 33.
REPEAT 2129 2188 34.
REPEAT 2189 2247 35.
REPEAT 2248 2306 36.
REPEAT 2307 2365 37.
REPEAT 2366 2424 38.
REPEAT 2425 2483 39.
REPEAT 2484 2540 40.
REPEAT 2542 2601 41.
REPEAT 2602 2653 42.
REPEAT 2654 2719 43.
REPEAT 2720 2770 44.
REPEAT 2772 2837 45.
REPEAT 2838 2896 46.
REPEAT 2897 2955 47.
REPEAT 2956 3014 48.
REPEAT 3015 3073 49.
REPEAT 3074 3132 50.
REPEAT 3133 3191 51.
REPEAT 3192 3247 52.
REPEAT 3249 3308 53.
REPEAT 3309 3367 54.
REPEAT 3368 3426 55.
REPEAT 3427 3485 56.
REPEAT 3486 3544 57.
REPEAT 3604 3662 58.
REPEAT 3663 3727 59.
DOMAIN 4131 4170 EGF-like.
DOMAIN 4182 4296 SEA.
REGION 185 3727 59 X approximate tandem repeats.
SITE 4243 4244 Cleavage (Potential).
DISULFID 4135 4147 By similarity.
DISULFID 4140 4158 By similarity.
DISULFID 4160 4169 By similarity.
Amino Acid Sequence for MUC17_HUMAN » Mucin-17
MPRPGTMALC LLTLVLSLLP PQAAAEQGLS VNRAVWDGGG CISQGDVLNR QCQQLSQHVR TGSATNTATG TTSTNVVEPR MYLSCSTNPE MTSIESSVTS DTPGVSSTRM TPTESRTTSE STSDSTTLFP SPTEDTSSPT TPEGTDVPMS TPSEESISST MAFVSTAPLP SFEAYTSLTY KVDMSTPLTT STQASSSPTT PESTTIPKST NSEGSTPLTS MPASTMKVAS SEAITLLTTP VEISTPVTIS AQASSSPTTA EGPSLSNSAP SGGSTPLTRM PLSVMLVVSS EASTLSTTPA ATNIPVITST EASSSPTTAE GTSIPTSTYT EGSTPLTSTP ASTMPVATSE MSTLSITPVD TSTLVTTSTE PSSLPTTAEA TSMLTSTLSE GSTPLTNMPV STILVASSEA STTSTIPVDS KTFVTTASEA SSSPTTAEDT SIATSTPSEG STPLTSMPVS TTPVASSEAS NLSTTPVDSK TQVTTSTEAS SSPPTAEVNS MPTSTPSEGS TPLTSMSVST MPVASSEAST LSTTPVDTST PVTTSSEASS SSTTPEGTSI PTSTPSEGST PLTNMPVSTR LVVSSEASTT STTPADSNTF VTTSSEASSS STTAEGTSMP TSTYSERGTT ITSMSVSTTL VASSEASTLS TTPVDSNTPV TTSTEATSSS TTAEGTSMPT STYTEGSTPL TSMPVNTTLV ASSEASTLST TPVDTSTPVT TSTEASSSPT TADGASMPTS TPSEGSTPLT SMPVSKTLLT SSEASTLSTT PLDTSTHITT STEASCSPTT TEGTSMPIST PSEGSPLLTS IPVSITPVTS PEASTLSTTP VDSNSPVTTS TEVSSSPTPA EGTSMPTSTY SEGRTPLTSM PVSTTLVATS AISTLSTTPV DTSTPVTNST EARSSPTTSE GTSMPTSTPG EGSTPLTSMP DSTTPVVSSE ARTLSATPVD TSTPVTTSTE ATSSPTTAEG TSIPTSTPSE GTTPLTSTPV SHTLVANSEA STLSTTPVDS NTPLTTSTEA SSPPPTAEGT SMPTSTPSEG STPLTRMPVS TTMVASSETS TLSTTPADTS TPVTTYSQAS SSSTTADGTS MPTSTYSEGS TPLTSVPVST RLVVSSEAST LSTTPVDTSI PVTTSTEASS SPTTAEGTSI PTSPPSEGTT PLASMPVSTT LVVSSEANTL STTPVDSKTQ VATSTEASSP PPTAEVTSMP TSTPGERSTP LTSMPVRHTP VASSEASTLS TSPVDTSTPV TTSAETSSSP TTAEGTSLPT STTSEGSTLL TSIPVSTTLV TSPEASTLLT TPVDTKGPVV TSNEVSSSPT PAEGTSMPTS TYSEGRTPLT SIPVNTTLVA SSAISILSTT PVDNSTPVTT STEACSSPTT SEGTSMPNSN PSEGTTPLTS IPVSTTPVVS SEASTLSATP VDTSTPGTTS AEATSSPTTA EGISIPTSTP SEGKTPLKSI PVSNTPVANS EASTLSTTPV DSNSPVVTST AVSSSPTPAE GTSIAISTPS EGSTALTSIP VSTTTVASSE INSLSTTPAV TSTPVTTYSQ ASSSPTTADG TSMQTSTYSE GSTPLTSLPV STMLVVSSEA NTLSTTPIDS KTQVTASTEA SSSTTAEGSS MTISTPSEGS PLLTSIPVST TPVASPEAST LSTTPVDSNS PVITSTEVSS SPTPAEGTSM PTSTYTEGRT PLTSITVRTT PVASSAISTL STTPVDNSTP VTTSTEARSS PTTSEGTSMP NSTPSEGTTP LTSIPVSTTP VLSSEASTLS ATPIDTSTPV TTSTEATSSP TTAEGTSIPT STLSEGMTPL TSTPVSHTLV ANSEASTLST TPVDSNSPVV TSTAVSSSPT PAEGTSIATS TPSEGSTALT SIPVSTTTVA SSETNTLSTT PAVTSTPVTT YAQVSSSPTT ADGSSMPTST PREGRPPLTS IPVSTTTVAS SEINTLSTTL ADTRTPVTTY SQASSSPTTA DGTSMPTPAY SEGSTPLTSM PLSTTLVVSS EASTLSTTPV DTSTPATTST EGSSSPTTAG GTSIQTSTPS ERTTPLAGMP VSTTLVVSSE GNTLSTTPVD SKTQVTNSTE ASSSATAEGS SMTISAPSEG SPLLTSIPLS TTPVASPEAS TLSTTPVDSN SPVITSTEVS SSPIPTEGTS MQTSTYSDRR TPLTSMPVST TVVASSAIST LSTTPVDTST PVTNSTEARS SPTTSEGTSM PTSTPSEGST PFTSMPVSTM PVVTSEASTL SATPVDTSTP VTTSTEATSS PTTAEGTSIP TSTLSEGTTP LTSIPVSHTL VANSEVSTLS TTPVDSNTPF TTSTEASSPP PTAEGTSMPT STSSEGNTPL TRMPVSTTMV ASFETSTLST TPADTSTPVT TYSQAGSSPT TADDTSMPTS TYSEGSTPLT SVPVSTMPVV SSEASTHSTT PVDTSTPVTT STEASSSPTT AEGTSIPTSP PSEGTTPLAS MPVSTTPVVS SEAGTLSTTP VDTSTPMTTS TEASSSPTTA EDIVVPISTA SEGSTLLTSI PVSTTPVASP EASTLSTTPV DSNSPVVTST EISSSATSAE GTSMPTSTYS EGSTPLRSMP VSTKPLASSE ASTLSTTPVD TSIPVTTSTE TSSSPTTAKD TSMPISTPSE VSTSLTSILV STMPVASSEA STLSTTPVDT RTLVTTSTGT SSSPTTAEGS SMPTSTPGER STPLTNILVS TTLLANSEAS TLSTTPVDTS TPVTTSAEAS SSPTTAEGTS MRISTPSDGS TPLTSILVST LPVASSEAST VSTTAVDTSI PVTTSTEASS SPTTAEVTSM PTSTPSETST PLTSMPVNHT PVASSEAGTL STTPVDTSTP VTTSTKASSS PTTAEGIVVP ISTASEGSTL LTSIPVSTTP VASSEASTLS TTPVDTSIPV TTSTEGSSSP TTAEGTSMPI STPSEVSTPL TSILVSTVPV AGSEASTLST TPVDTRTPVT TSAEASSSPT TAEGTSMPIS TPGERRTPLT SMSVSTMPVA SSEASTLSRT PADTSTPVTT STEASSSPTT AEGTGIPIST PSEGSTPLTS IPVSTTPVAI PEASTLSTTP VDSNSPVVTS TEVSSSPTPA EGTSMPISTY SEGSTPLTGV PVSTTPVTSS AISTLSTTPV DTSTPVTTST EAHSSPTTSE GTSMPTSTPS EGSTPLTYMP VSTMLVVSSE DSTLSATPVD TSTPVTTSTE ATSSTTAEGT SIPTSTPSEG MTPLTSVPVS NTPVASSEAS ILSTTPVDSN TPLTTSTEAS SSPPTAEGTS MPTSTPSEGS TPLTSMPVST TTVASSETST LSTTPADTST PVTTYSQASS SPPIADGTSM PTSTYSEGST PLTNMSFSTT PVVSSEASTL STTPVDTSTP VTTSTEASLS PTTAEGTSIP TSSPSEGTTP LASMPVSTTP VVSSEVNTLS TTPVDSNTLV TTSTEASSSP TIAEGTSLPT STTSEGSTPL SIMPLSTTPV ASSEASTLST TPVDTSTPVT TSSPTNSSPT TAEVTSMPTS TAGEGSTPLT NMPVSTTPVA SSEASTLSTT PVDSNTFVTS SSQASSSPAT LQVTTMRMST PSEGSSSLTT MLLSSTYVTS SEASTPSTPS VDRSTPVTTS TQSNSTPTPP EVITLPMSTP SEVSTPLTIM PVSTTSVTIS EAGTASTLPV DTSTPVITST QVSSSPVTPE GTTMPIWTPS EGSTPLTTMP VSTTRVTSSE GSTLSTPSVV TSTPVTTSTE AISSSATLDS TTMSVSMPME ISTLGTTILV STTPVTRFPE SSTPSIPSVY TSMSMTTASE GSSSPTTLEG TTTMPMSTTS ERSTLLTTVL ISPISVMSPS EASTLSTPPG DTSTPLLTST KAGSFSIPAE VTTIRISITS ERSTPLTTLL VSTTLPTSFP GASIASTPPL DTSTTFTPST DTASTPTIPV ATTISVSVIT EGSTPGTTIF IPSTPVTSST ADVFPATTGA VSTPVITSTE LNTPSTSSSS TTTSFSTTKE FTTPAMTTAA PLTYVTMSTA PSTPRTTSRG CTTSASTLSA TSTPHTSTSV TTRPVTPSSE SSRPSTITSH TIPPTFPPAH SSTPPTTSAS STTVNPEAVT TMTTRTKPST RTTSFPTVTT TAVPTNTTIK SNPTSTPTVP RTTTCFGDGC QNTASRCKNG GTWDGLKCQC PNLYYGELCE EVVSSIDIGP PETISAQMEL TVTVTSVKFT EELKNHSSQE FQEFKQTFTE QMNIVYSGIP EYVGVNITKL RLGSVVVEHD VLLRTKYTPE YKTVLDNATE VVKEKITKVT TQQIMINDIC SDMMCFNTTG TQVQNITVTQ YDPEEDCRKM AKEYGDYFVV EYRDQKPYCI SPCEPGFSVS KNCNLGKCQM SLSGPQCLCV TTETHWYSGE TCNQGTQKSL VYGLVGAGVV LMLIILVALL MLVFRSKREV KRQKYRLSQL YKWQEEDSGP APGTFQNIGF DICQDDDSIH LESIYSNFQP SLRHIDPETK IRIQRPQVMT TSF