MUC13_HUMAN » Mucin-13

MUC13_HUMAN » Mucin-13
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MUC13_HUMAN » Mucin-13 » MUC-13; Down-regulated in colon cancer 1;
Hydrophobic Thickness 34.4 ± 1.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -49.3 kcal/mol
ΔGfold -23.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 419-445 (415-447)
Pathways none
PDB none
OPM none
Complexes none
Interactions

GLT14, Complex: GLT14:MUC13, PubMed

Domains

AA: 214-323, PDBID: 2ACM, Subunit A, Seq Identity:17%, SEA domain

UniProt annotation for MUC13_HUMAN » Mucin-13
FUNCTION: Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.

SUBUNIT: Homodimer of beta subunits.

TISSUE SPECIFICITY: Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.

UniProt features for MUC13_HUMAN » Mucin-13
SIGNAL 1 18 Potential.
CHAIN 19 511 Mucin-13.
DOMAIN 172 210 EGF-like 1.
DOMAIN 211 320 SEA.
DOMAIN 321 360 EGF-like 2.
DOMAIN 362 403 EGF-like 3.
DISULFID 176 187 By similarity.
DISULFID 181 196 By similarity.
DISULFID 198 209 By similarity.
DISULFID 325 337 By similarity.
DISULFID 330 343 By similarity.
DISULFID 345 359 By similarity.
DISULFID 366 377 By similarity.
DISULFID 370 388 By similarity.
DISULFID 390 402 By similarity.
Amino Acid Sequence for MUC13_HUMAN » Mucin-13
MKAIIHLTLL ALLSVNTATN QGNSADAVTT TETATSGPTV AAADTTETNF PETASTTANT PSFPTATSPA PPIISTHSSS TIPTPAPPII STHSSSTIPI PTAADSESTT NVNSLATSDI ITASSPNDGL ITMVPSETQS NNEMSPTTED NQSSGPPTGT ALLETSTLNS TGPSNPCQDD PCADNSLCVK LHNTSFCLCL EGYYYNSSTC KKGKVFPGKI SVTVSETFDP EEKHSMAYQD LHSEITSLFK DVFGTSVYGQ TVILTVSTSL SPRSEMRADD KFVNVTIVTI LAETTSDNEK TVTEKINKAI RSSSSNFLNY DLTLRCDYYG CNQTADDCLN GLACDCKSDL QRPNPQSPFC VASSLKCPDA CNAQHKQCLI KKSGGAPECA CVPGYQEDAN GNCQKCAFGY SGLDCKDKFQ LILTIVGTIA GIVILSMIIA LIVTARSNNK TKHIEEENLI DEDFQNLKLR STGFTNLGAE GSVFPKVRIT ASRDSQMQNP YSRHSSMPRP DY