MUC12_HUMAN » Mucin-12

MUC12_HUMAN » Mucin-12
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MUC12_HUMAN » Mucin-12 » MUC-12; Mucin-11;MUC-11;
Hydrophobic Thickness 40.8 ± 2.2 Å
Tilt Angle 1 ± 3°
ΔGtransfer -65.0 kcal/mol
ΔGfold -30.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 5378-5403 (5374-5411)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 5171-5272, PDBID: 2ACM, Subunit A, Seq Identity:16%, SEA domain

UniProt annotation for MUC12_HUMAN » Mucin-12
FUNCTION: Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium.

TISSUE SPECIFICITY: Ubiquitous, with higher expression in colon. Down-regulated in colorectal cancer as well as in the colon of patients with ulcerative colitis (UC) and Crohn"s disease (CD).

INDUCTION: By listeriolysin O.

DOMAIN: The proteolytic cleavage occurs within the SEA domain. This domain is not interchangeable, suggesting that it is insufficient to mediate efficient cleavage.

MISCELLANEOUS: Infection by L.monocytogenes induces increases in mucin secretion and MUC4 and MUC12 transcription. This may constitute a host cell defense response that inhibits the entry of listeria monocytogenes in the cell.

UniProt features for MUC12_HUMAN » Mucin-12
SIGNAL 1 16 Potential.
CHAIN 17 5478 Mucin-12.
REPEAT 222 240 1.
REPEAT 471 489 2.
REPEAT 499 517 3.
REPEAT 662 680 4.
REPEAT 827 845 5.
REPEAT 1159 1177 6.
REPEAT 1466 1484 7.
REPEAT 1633 1651 8.
REPEAT 1717 1735 9.
REPEAT 1882 1900 10.
REPEAT 1910 1928 11.
REPEAT 2075 2093 12.
REPEAT 2242 2260 13.
REPEAT 2549 2567 14.
REPEAT 2716 2734 15.
REPEAT 3023 3041 16.
REPEAT 3190 3208 17.
REPEAT 3274 3292 18.
REPEAT 3439 3457 19.
REPEAT 3467 3485 20.
REPEAT 3632 3650 21.
REPEAT 3799 3817 22.
REPEAT 4106 4124 23.
REPEAT 4273 4291 24.
REPEAT 4522 4540 25.
REPEAT 4550 4568 26.
REPEAT 4715 4733 27.
REPEAT 4743 4761 28.
DOMAIN 5116 5154 EGF-like.
DOMAIN 5163 5290 SEA.
REGION 222 4761 28 X 19 AA approximate tandem repeats of E-E-S-X-X-X-H-X-X-P-X-X-T-X-T-X-X-X-P.
MOTIF 5226 5233 Cleavage motif (By similarity).
SITE 5229 5230 Cleavage (By similarity).
DISULFID 5144 5153 By similarity.
Amino Acid Sequence for MUC12_HUMAN » Mucin-12
MLVIWILTLA LRLCASVTTV TPEGSAVHKA ISQQGTLWTG EVLEKQTVEQ GKSTLRRQKN HFHRSAGELR CRNALKDEGA SAGWSVMFAG ESVVVLVHLW MTGARVKNLG LVEFASPGDD GDGRAEGFSL GLPLSEQARA AGAREKERQE TVINHSTFSG FSQITGSTVN TSIGGNTTSA STPSSSDPFT TFSDYGVSVT FITGSTATKH FLDSSTNSGH SEESTVSHSG PGATGTTLFP SHSATSVFVG EPKTSPITSA SMETTALPGS TTTAGLSEKS TTFYSSPRSP DRTLSPARTT SSGVSEKSTT SHSRPGPTHT IAFPDSTTMP GVSQESTASH SIPGSTDTTL SPGTTTPSSL GPESTTFHSS PGYTKTTRLP DNTTTSGLLE ASTPVHSSTG SPHTTLSPSS STTHEGEPTT FQSWPSSKDT SPAPSGTTSA FVKLSTTYHS SPSSTPTTHF SASSTTLGHS EESTPVHSSP VATATTPPPA RSATSGHVEE STAYHRSPGS TQTMHFPESS TTSGHSEESA TFHGSTTHTK SSTPSTTAAL AHTSYHSSLG STETTHFRDS STISGRSEES KASHSSPDAM ATTVLPAGST PSVLVGDSTP SPISSGSMET TALPGSTTKP GLSEKSTTFY SSPRSPDTTH LPASMTSSGV SEESTTSHSR PGSTHTTAFP GSTTMPGLSQ ESTASHSSPG PTDTTLSPGS TTASSLGPEY TTFHSRPGST ETTLLPDNTT ASGLLEASMP VHSSTRSPHT TLSPAGSTTR QGESTTFHSW PSSKDTRPAP PTTTSAFVEP STTSHGSPSS IPTTHISARS TTSGLVEEST TYHSSPGSTQ TMHFPESDTT SGRGEESTTS HSSTTHTISS APSTTSALVE EPTSYHSSPG STATTHFPDS STTSGRSEES TASHSSQDAT GTIVLPARST TSVLLGESTT SPISSGSMET TALPGSTTTP GLSERSTTFH SSPRSPATTL SPASTTSSGV SEESTTSRSR PGSTHTTAFP DSTTTPGLSR HSTTSHSSPG STDTTLLPAS TTTSGPSQES TTSHSSSGST DTALSPGSTT ALSFGQESTT FHSNPGSTHT TLFPDSTTSS GIVEASTRVH SSTGSPRTTL SPASSTSPGL QGESTAFQTH PASTHTTPSP PSTATAPVEE STTYHRSPGS TPTTHFPASS TTSGHSEKST IFHSSPDASG TTPSSAHSTT SGRGESTTSR ISPGSTEITT LPGSTTTPGL SEASTTFYSS PRSPTTTLSP ASMTSLGVGE ESTTSRSQPG STHSTVSPAS TTTPGLSEES TTVYSSSRGS TETTVFPHST TTSVHGEEPT TFHSRPASTH TTLFTEDSTT SGLTEESTAF PGSPASTQTG LPATLTTADL GEESTTFPSS SGSTGTKLSP ARSTTSGLVG ESTPSRLSPS STETTTLPGS PTTPSLSEKS TTFYTSPRSP DATLSPATTT SSGVSEESST SHSQPGSTHT TAFPDSTTTS DLSQEPTTSH SSQGSTEATL SPGSTTASSL GQQSTTFHSS PGDTETTLLP DDTITSGLVE ASTPTHSSTG SLHTTLTPAS STSAGLQEES TTFQSWPSSS DTTPSPPGTT AAPVEVSTTY HSRPSSTPTT HFSASSTTLG RSEESTTVHS SPGATGTALF PTRSATSVLV GEPTTSPISS GSTETTALPG STTTAGLSEK STTFYSSPRS PDTTLSPAST TSSGVSEEST TSHSRPGSTH TTAFPGSTTM PGVSQESTAS HSSPGSTDTT LSPGSTTASS LGPESTTFHS SPGSTETTLL PDNTTASGLL EASTPVHSST GSPHTTLSPA GSTTRQGEST TFQSWPSSKD TMPAPPTTTS AFVELSTTSH GSPSSTPTTH FSASSTTLGR SEESTTVHSS PVATATTPSP ARSTTSGLVE ESTAYHSSPG STQTMHFPES STASGRSEES RTSHSSTTHT ISSPPSTTSA LVEEPTSYHS SPGSTATTHF PDSSTTSGRS EESTASHSSQ DATGTIVLPA RSTTSVLLGE STTSPISSGS METTALPGST TTPGLSEKST TFHSSPRSPA TTLSPASTTS SGVSEESTTS HSRPGSTHTT AFPDSTTTPG LSRHSTTSHS SPGSTDTTLL PASTTTSGPS QESTTSHSSP GSTDTALSPG STTALSFGQE STTFHSSPGS THTTLFPDST TSSGIVEAST RVHSSTGSPR TTLSPASSTS PGLQGESTAF QTHPASTHTT PSPPSTATAP VEESTTYHRS PGSTPTTHFP ASSTTSGHSE KSTIFHSSPD ASGTTPSSAH STTSGRGEST TSRISPGSTE ITTLPGSTTT PGLSEASTTF YSSPRSPTTT LSPASMTSLG VGEESTTSRS QPGSTHSTVS PASTTTPGLS EESTTVYSSS PGSTETTVFP RTPTTSVRGE EPTTFHSRPA STHTTLFTED STTSGLTEES TAFPGSPAST QTGLPATLTT ADLGEESTTF PSSSGSTGTT LSPARSTTSG LVGESTPSRL SPSSTETTTL PGSPTTPSLS EKSTTFYTSP RSPDATLSPA TTTSSGVSEE SSTSHSQPGS THTTAFPDST TTPGLSRHST TSHSSPGSTD TTLLPASTTT SGPSQESTTS HSSPGSTDTA LSPGSTTALS FGQESTTFHS SPGSTHTTLF PDSTTSSGIV EASTRVHSST GSPRTTLSPA SSTSPGLQGE STTFQTHPAS THTTPSPPST ATAPVEESTT YHRSPGSTPT THFPASSTTS GHSEKSTIFH SSPDASGTTP SSAHSTTSGR GESTTSRISP GSTEITTLPG STTTPGLSEA STTFYSSPRS PTTTLSPASM TSLGVGEEST TSRSQPGSTH STVSPASTTT PGLSEESTTV YSSSPGSTET TVFPRSTTTS VRGEEPTTFH SRPASTHTTL FTEDSTTSGL TEESTAFPGS PASTQTGLPA TLTTADLGEE STTFPSSSGS TGTTLSPARS TTSGLVGEST PSRLSPSSTE TTTLPGSPTT PSLSEKSTTF YTSPRSPDAT LSPATTTSSG VSEESSTSHS QPGSTHTTAF PDSTTTSGLS QEPTASHSSQ GSTEATLSPG STTASSLGQQ STTFHSSPGD TETTLLPDDT ITSGLVEAST PTHSSTGSLH TTLTPASSTS AGLQEESTTF QSWPSSSDTT PSPPGTTAAP VEVSTTYHSR PSSTPTTHFS ASSTTLGRSE ESTTVHSSPG ATGTALFPTR SATSVLVGEP TTSPISSGST ETTALPGSTT TAGLSEKSTT FYSSPRSPDT TLSPASTTSS GVSEESTTSH SRPGSTHTTA FPGSTTMPGV SQESTASHSS PGSTDTTLSP GSTTASSLGP ESTTFHSGPG STETTLLPDN TTASGLLEAS TPVHSSTGSP HTTLSPAGST TRQGESTTFQ SWPNSKDTTP APPTTTSAFV ELSTTSHGSP SSTPTTHFSA SSTTLGRSEE STTVHSSPVA TATTPSPARS TTSGLVEEST TYHSSPGSTQ TMHFPESDTT SGRGEESTTS HSSTTHTISS APSTTSALVE EPTSYHSSPG STATTHFPDS STTSGRSEES TASHSSQDAT GTIVLPARST TSVLLGESTT SPISSGSMET TALPGSTTTP GLSEKSTTFH SSPRSPATTL SPASTTSSGV SEESTTSHSR PGSTHTTAFP DSTTTPGLSR HSTTSHSSPG STDTTLLPAS TTTSGSSQES TTSHSSSGST DTALSPGSTT ALSFGQESTT FHSSPGSTHT TLFPDSTTSS GIVEASTRVH SSTGSPRTTL SPASSTSPGL QGESTAFQTH PASTHTTPSP PSTATAPVEE STTYHRSPGS TPTTHFPASS TTSGHSEKST IFHSSPDASG TTPSSAHSTT SGRGESTTSR ISPGSTEITT LPGSTTTPGL SEASTTFYSS PRSPTTTLSP ASMTSLGVGE ESTTSRSQPG STHSTVSPAS TTTPGLSEES TTVYSSSPGS TETTVFPRST TTSVRREEPT TFHSRPASTH TTLFTEDSTT SGLTEESTAF PGSPASTQTG LPATLTTADL GEESTTFPSS SGSTGTKLSP ARSTTSGLVG ESTPSRLSPS STETTTLPGS PTTPSLSEKS TTFYTSPRSP DATLSPATTT SSGVSEESST SHSQPGSTHT TAFPDSTTTS GLSQEPTTSH SSQGSTEATL SPGSTTASSL GQQSTTFHSS PGDTETTLLP DDTITSGLVE ASTPTHSSTG SLHTTLTPAS STSTGLQEES TTFQSWPSSS DTTPSPPSTT AVPVEVSTTY HSRPSSTPTT HFSASSTTLG RSEESTTVHS SPGATGTALF PTRSATSVLV GEPTTSPISS GSTETTALPG STTTAGLSEK STTFYSSPRS PDTTLSPAST TSSGVSEEST TSHSRPGSMH TTAFPSSTTM PGVSQESTAS HSSPGSTDTT LSPGSTTASS LGPESTTFHS SPGSTETTLL PDNTTASGLL EASTPVHSST GSPHTTLSPA GSTTRQGEST TFQSWPNSKD TTPAPPTTTS AFVELSTTSH GSPSSTPTTH FSASSTTLGR SEESTTVHSS PVATATTPSP ARSTTSGLVE ESTTYHSSPG STQTMHFPES NTTSGRGEES TTSHSSTTHT ISSAPSTTSA LVEEPTSYHS SPGSTATTHF PDSSTTSGRS EESTASHSSQ DATGTIVLPA RSTTSVLLGE STTSPISSGS METTALPGST TTPGLSEKST TFHSSPSSTP TTHFSASSTT LGRSEESTTV HSSPVATATT PSPARSTTSG LVEESTAYHS SPGSTQTMHF PESSTASGRS EESRTSHSST THTISSPPST TSALVEEPTS YHSSPGSIAT THFPESSTTS GRSEESTASH SSPDTNGITP LPAHFTTSGR IAESTTFYIS PGSMETTLAS TATTPGLSAK STILYSSSRS PDQTLSPASM TSSSISGEPT SLYSQAESTH TTAFPASTTT SGLSQESTTF HSKPGSTETT LSPGSITTSS FAQEFTTPHS QPGSALSTVS PASTTVPGLS EESTTFYSSP GSTETTAFSH SNTMSIHSQQ STPFPDSPGF THTVLPATLT TTDIGQESTA FHSSSDATGT TPLPARSTAS DLVGEPTTFY ISPSPTYTTL FPASSSTSGL TEESTTFHTS PSFTSTIVST ESLETLAPGL CQEGQIWNGK QCVCPQGYVG YQCLSPLESF PVETPEKLNA TLGMTVKVTY RNFTEKMNDA SSQEYQNFST LFKNRMDVVL KGDNLPQYRG VNIRRLLNGS IVVKNDVILE ADYTLEYEEL FENLAEIVKA KIMNETRTTL LDPDSCRKAI LCYSEEDTFV DSSVTPGFDF QEQCTQKAAE GYTQFYYVDV LDGKLACVNK CTKGTKSQMN CNLGTCQLQR SGPRCLCPNT NTHWYWGETC EFNIAKSLVY GIVGAVMAVL LLALIILIIL FSLSQRKRHR EQYDVPQEWR KEGTPGIFQK TAIWEDQNLR ESRFGLENAY NNFRPTLETV DSGTELHIQR PEMVASTV