MTX1_HUMAN » Metaxin-1

MTX1_HUMAN » Metaxin-1
Magnify MTX1_HUMAN » Metaxin-1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Mitochondrial outer membrane
Topologyintermembrane space
cytoplasmic side
MTX1_HUMAN » Metaxin-1 » Mitochondrial outer membrane import complex protein 1;
Hydrophobic Thickness 33.2 ± 2.7 Å
Tilt Angle 11 ± 10°
ΔGtransfer -17.1 kcal/mol
ΔGfold -15.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology In
TM Segments 419-441 (412-446)
Pathways none
PDB none
OPM none
Complexes none
Interactions

CISD1, Complex: CISD1:MTX1, PubMed

IMMT, Complex: MTX1:MTX2:IMMT:DJC11:CHCH3:SAM50:CHCH6, PubMed

IMMT, Complex: MIC60:MTX1, PubMed

MOS1, Complex: MOS1:MTX1, PubMed

Domains

AA: 156-293, Outer mitochondrial membrane transport complex protein

AA: 323-386, Glutathione S-transferase, C-terminal domain

UniProt annotation for MTX1_HUMAN » Metaxin-1
FUNCTION: Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).

SUBUNIT: Interacts with MTX2/metaxin-2. Associates with the MINOS/MitOS complex, that includes IMMT, HSPA9 and CHCHD3.

UniProt features for MTX1_HUMAN » Metaxin-1
CHAIN 1 466 Metaxin-1.
Amino Acid Sequence for MTX1_HUMAN » Metaxin-1
MLLGGPPRSP RSGTSPKGPW SSTGHVQFGK SPQTWPRRTR PRSPEPAAPS GVRGSTWTRR RDTPRRAGPT ALSRYVGHLW MGRRPPSPEA RGPVPRSSAA SRARRSLASP GISPGPLTAT IGGAVAGGGP RQGRAEAHKE VFPGQRVGKM AAPMELFCWS GGWGLPSVDL DSLAVLTYAR FTGAPLKVHK ISNPWQSPSG TLPALRTSHG EVISVPHKII THLRKEKYNA DYDLSARQGA DTLAFMSLLE EKLLPVLVHT FWIDTKNYVE VTRKWYAEAM PFPLNFFLPG RMQRQYMERL QLLTGEHRPE DEEELEKELY REARECLTLL SQRLGSQKFF FGDAPASLDA FVFSYLALLL QAKLPSGKLQ VHLRGLHNLC AYCTHILSLY FPWDGAEVPP QRQTPAGPET EEEPYRRRNQ ILSVLAGLAA MVGYALLSGI VSIQRATPAR APGTRTLGMA EEDEEE