MTL1_YEAST » Protein MTL1

MTL1_YEAST » Protein MTL1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MTL1_YEAST » Protein MTL1 » MID two-like protein 1;
Hydrophobic Thickness 27.6 ± 2.0 Å
Tilt Angle 0 ± 2°
ΔGtransfer -36.7 kcal/mol
ΔGfold -17.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 361-386 (360-388)
Pathways none
PDB none
OPM none
Complexes none
Interactions

EAR1, Complex: EAR1:MTL1

MID2, Complex: MID2:MTL1, PubMed

Domains

AA: 315-466, Mid2 like cell wall stress sensor

UniProt annotation for MTL1_YEAST » Protein MTL1
FUNCTION: Involved in cell integrity signaling during vegetative growth at elevated temperature. Acts positively on the PKC1-MAPK pathway. Cell membrane sensor of oxidative stress in the cell integrity pathway upstream of PKC1. Required to transmit the oxidative signal to SLT2 and to restore the correct actin organization following oxidative stress. Multicopy suppressor of 1,3-beta-glucan synthase (GS) mutation. Also suppresses RGD1 null mutations.
UniProt features for MTL1_YEAST » Protein MTL1
SIGNAL 1 35 Potential.
CHAIN 36 551 Protein MTL1.
Amino Acid Sequence for MTL1_YEAST » Protein MTL1
MASCNPTRKK SSASSLSMWR TILMALTTLP LSVLSQELVP ANSTTSSTAP SITSLSAVES FTSSTDATSS ASLSTPSIAS VSFTSFPQSS SLLTLSSTLS SELSSSSMQV SSSSTSSSSS EVTSSSSSSS ISPSSSSSTI ISSSSSLPTF TVASTSSTVA SSTLSTSSSL VISTSSSTFT FSSESSSSLI SSSISTSVST SSVYVPSSST SSPPSSSSEL TSSSYSSSSS SSTLFSYSSS FSSSSSSSSS SSSSSSSSSS SSSSYFTLST SSSSSIYSSS SYPSFSSSSS SNPTSSITST SASSSITPAS EYSNLAKTIT SIIEGQTILS NYYTTITYSP TASASSGKNS HHSGLSKKNR NIIIGCVVGI GAPLILILLI LIYMFCVQPK KTDFIDSDGK IVTAYRSNIF TKIWYFLLGK KIGETERFSS DSPIGSNNIQ NFGDIDPEDI LNNDNPYTPK HTNVEGYDDD DDDDANDENL SSNFHNRGID DQYSPTKSAS YSMSNSNSQD YNDADEVMHD ENIHRVYDDS EASIDENYYT KPNNGLNITN Y