MSRE_HUMAN » Macrophage scavenger receptor types I and II

MSRE_HUMAN » Macrophage scavenger receptor types I and II
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MSRE_HUMAN » Macrophage scavenger receptor types I and II » Macrophage acetylated LDL receptor I and II;Scavenger receptor class A member 1;
Hydrophobic Thickness 38.4 ± 2.0 Å
Tilt Angle 32 ± 0°
ΔGtransfer -28.7 kcal/mol
ΔGfold -22.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 51-80 (51-81)
Pathways

Aminoacyl-tRNA biosynthesis (KEGG)

Phagosome (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 121-169, Macrophage scavenger receptor

AA: 271-335, PDBID: 3GXE, Subunit F, Seq Identity:44%, Collagen triple helix repeat (20 copies)

AA: 353-450, PDBID: 1BY2, Subunit A, Seq Identity:48%, Scavenger receptor cysteine-rich domain

UniProt annotation for MSRE_HUMAN » Macrophage scavenger receptor types I and II
FUNCTION: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.

SUBUNIT: Homotrimer.

TISSUE SPECIFICITY: Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages.

DISEASE: Prostate cancer (PC) OMIM: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. disease may be caused by mutations affecting the gene represented in this entry. MSR1 variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with prostate cancer and co-segregate with the disease in some families.

DISEASE: Barrett esophagus (BE) OMIM: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. caused by mutations affecting the gene represented in this entry. Genetic variants in MSR1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility.

UniProt features for MSRE_HUMAN » Macrophage scavenger receptor types I and II
CHAIN 1 451 Macrophage scavenger receptor types I and II.
DOMAIN 273 341 Collagen-like.
DOMAIN 350 450 SRCR.
REGION 77 109 Spacer (Probable).
COILED 171 255 Potential.
DISULFID 375 439
DISULFID 388 449
DISULFID 419 429
Amino Acid Sequence for MSRE_HUMAN » Macrophage scavenger receptor types I and II
MEQWDHFHNQ QEDTDSCSES VKFDARSMTA LLPPNPKNSP SLQEKLKSFK AALIALYLLV FAVLIPLIGI VAAQLLKWET KNCSVSSTNA NDITQSLTGK GNDSEEEMRF QEVFMEHMSN MEKRIQHILD MEANLMDTEH FQNFSMTTDQ RFNDILLQLS TLFSSVQGHG NAIDEISKSL ISLNTTLLDL QLNIENLNGK IQENTFKQQE EISKLEERVY NVSAEIMAMK EEQVHLEQEI KGEVKVLNNI TNDLRLKDWE HSQTLRNITL IQGPPGPPGE KGDRGPTGES GPRGFPGPIG PPGLKGDRGA IGFPGSRGLP GYAGRPGNSG PKGQKGEKGS GNTLTPFTKV RLVGGSGPHE GRVEILHSGQ WGTICDDRWE VRVGQVVCRS LGYPGVQAVH KAAHFGQGTG PIWLNEVFCF GRESSIEECK IRQWGTRACS HSEDAGVTCT L