MSB2_YEAST » Signaling mucin MSB2

MSB2_YEAST » Signaling mucin MSB2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MSB2_YEAST » Signaling mucin MSB2 » Multicopy suppressor of bud emergence 2;Osmosensor MSB2;
Hydrophobic Thickness 35.6 ± 0.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -46.6 kcal/mol
ΔGfold -21.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 1182-1211 (1178-1215)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ANP1, Complex: MSB2:ANP1

MNN11, Complex: MNN11:MSB2

MNT2, Complex: MSB2:MNT2

OPY2, Complex: MSB2:OPY2

PSD1, Complex: PSD1:MSB2

YB255, Complex: MSB2:YB255, PubMed

Domains none
UniProt annotation for MSB2_YEAST » Signaling mucin MSB2
FUNCTION: Plasma membrane signaling mucin that promotes activation of the MAPK for the filamentous growth pathway. Partially redundant with the SHO1 osmosensing branch for the activation of STE11.

SUBUNIT: Interacts with CDC42 and SHO1.

MISCELLANEOUS: Present with 1320 molecules/cell in log phase SD medium.

UniProt features for MSB2_YEAST » Signaling mucin MSB2
SIGNAL 1 21 Potential.
CHAIN 22 1306 Signaling mucin MSB2.
REPEAT 698 714 1.
REPEAT 715 731 2.
REPEAT 732 748 3.
REPEAT 749 765 4.
REPEAT 766 782 5.
REPEAT 783 799 6.
REPEAT 800 816 7.
REGION 698 816 7 X 17 AA tandem repeats.
Amino Acid Sequence for MSB2_YEAST » Signaling mucin MSB2
MQFPFACLLS TLVISGSLAR ASPFDFIFGN GTQQAQSQSE SQGQVSFTNE ASQDSSTTSL VTAYSQGVHS HQSATIVSAT ISSLPSTWYD ASSTSQTSVS YASQESDYAV NQNSWSASTN QLPSTSTTSY YAPTFSTSAD FAASSVNAAS DVSTASVPID TSANSIPFTT TSNIETTTSA PLTSDTPLIS TSTMSAADNV FSSANPISAS LTTTDSSESF DQTSTAGAIP VQSSADFSSS SEILVQSSAD FSSPSSPTTT DISLSAAPLQ TSESSSFTTA SAALPVSSTD VDGSSASPVV SMSAAGQIAS SSSTDNPTMS ETFSLTSTEV DGSDVSSTVS ALLSAPFLQT STSNSFSIVS PSVSFVPSQS SSDVASSSTA NVVSSSFSDI PPQTSTSGSV VSVAQSASAL AFQSSTEVYG ASASSTMSSL LSTTSLQSTT LDSSSLASSS ASSSDLTDYG VSSTASIPLL SASEQASTSS SFSVVSPSVS FVPSQSSSDV ASTSAPSVVS SSFSYTSLQA GGSSMTNPSS STIVYSSSTG SSEESAASTA SATLSGSSST YMAGNLQSQP PSTSSLLSES QATSTSAVLA SSSVSTTSPY TTAGGASTEA SSLISSTSAE TSQVSYSQST TALQTSSFAS SSTTEGSETS SQGFSTSSVL VQMPSSISSE FSPSQTTTQM NSASSSSQYT ISSTGILSQV SDTSVSYTTS SSSVSQVSDT PVSYTTSSSS VSQVSDTPVS YTTSSSSVSQ VSDTPVSYTT SSSSVSQVSD TPVSYTTSSS SVSQVSDTSV PSTSSRSSVS QVSDTPVPST SSRSSVSQTS SSLQPTTTSS QRFTISTHGA LSESSSVSQQ ASEITSSINA TASEYHSIQT TAATQSTTLS FTDANSSSAS APLEVATSTP TPSSKASSLL LTPSTSSLSQ VATNTNVQTS LTTESTTVLE PSTTNSSSTF SLVTSSDNNW WIPTELITQA PEAASTASST VGGTQTMTLP HAIAAATQVP EPEGYTLITI GFKKALNYEF VVSEPKSSAQ IFGYLPEALN TPFKNVFTNI TVLQIVPLQD DSLNYLVSVA EVYFPTAEIE ELSNLITNSS SAFYTDGMGT AKSMAAMVDS SIPLTGLLHD SNSNSGGSSD GSSSSNSNSG SSGSGSNSNS GVSSSSGNSY QDAGTLEYSS KSNSNVSTSS KSKKKIIGLV IGVVVGGCLY ILFMIFAFKY IIRRRIQSQE IIKNPEISSI SSSEFGGEKN YNNEKRMSVQ ESITQSMRIQ NWMDDSYYGH GLTNNDSTPT RHNTSSSIPK ISRPIASQNS LGWNEV