MRVI1_HUMAN » Protein MRVI1

MRVI1_HUMAN » Protein MRVI1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
MRVI1_HUMAN » Protein MRVI1 » Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate;JAW1-related protein MRVI1;
Hydrophobic Thickness 31.6 ± 2.0 Å
Tilt Angle 3 ± 8°
ΔGtransfer -25.5 kcal/mol
ΔGfold -18.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 825-846 (823-848)
Pathways

Hemostasis (Reactome)

Vascular smooth muscle contraction (KEGG)

PDB none
OPM none
Complexes none
Interactions

NEP, Complex: MRVI1:NEP, PubMed

PPLA, Complex: ITPR1:MRVI1:ACTS:KGP1:PPLA:CNN1, PubMed

Domains

AA: 299-885, MRVI1 protein

UniProt annotation for MRVI1_HUMAN » Protein MRVI1
FUNCTION: Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation.

SUBUNIT: Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with PRKG1/cGKI-beta and ITPR1/IP3R type I.

TISSUE SPECIFICITY: Expressed in the colon, rectum, and cultured colonic smooth muscle. Detected in various cancer cell lines.

INDUCTION: By silencing of the transcription factor BTF3.

UniProt features for MRVI1_HUMAN » Protein MRVI1
CHAIN 1 885 Protein MRVI1.
REGION 144 176 Interaction with PRKG1 (By similarity).
REGION 508 554 Interaction with ITPR1 (By similarity).
COILED 521 619 Potential.
Amino Acid Sequence for MRVI1_HUMAN » Protein MRVI1
MGMDLTCPFG ISPACGAQAS WSIFGADAAE VPGTRGHSQQ EAAMPHIPED EEPPGEPQAA QSPAGQGPPA AGVSCSPTPT IVLTGDATSP EGETDKNLAN RVHSPHKRLS HRHLKVSTAS LTSVDPAGHI IDLVNDQLPD ISISEEDKKK NLALLEEAKL VSERFLTRRG RKSRSSPGDS PSAVSPNLSP SASPTSSRSN SLTVPTPPDG DEADVSSPHP GEPNVPKGLA DRKQNDQRKV SQGRLAPRPP PVEKSKEIAI EQKENFDPLQ YPETTPKGLA PVTNSSGKMA LNSPQPGPVE SELGKQLLKT GWEGSPLPRS PTQDAAGVGP PASQGRGPAG EPMGPEAGSK AELPPTVSRP PLLRGLSWDS GPEEPGPRLQ KVLAKLPLAE EEKRFAGKAG GKLAKAPGLK DFQIQVQPVR MQKLTKLREE HILMRNQNLV GLKLPDLSEA AEQEKGLPSE LSPAIEEEES KSGLDVMPNI SDVLLRKLRV HRSLPGSAPP LTEKEVENVF VQLSLAFRND SYTLESRINQ AERERNLTEE NTEKELENFK ASITSSASLW HHCEHRETYQ KLLEDIAVLH RLAARLSSRA EVVGAVRQEK RMSKATEVMM QYVENLKRTY EKDHAELMEF KKLANQNSSR SCGPSEDGVP RTARSMSLTL GKNMPRRRVS VAVVPKFNAL NLPGQTPSSS SIPSLPALSE SPNGKGSLPV TSALPALLEN GKTNGDPDCE ASAPALTLSC LEELSQETKA RMEEEAYSKG FQEGLKKTKE LQDLKEEEEE QKSESPEEPE EVEETEEEEK GPRSSKLEEL VHFLQVMYPK LCQHWQVIWM MAAVMLVLTV VLGLYNSYNS CAEQADGPLG RSTCSAAQRD SWWSSGLQHE QPTEQ