MRC1_HUMAN » Macrophage mannose receptor 1
- Type: 1. Transmembrane bitopic proteins (15 classes)
- Class: 1.01. Receptors (68 superfamilies)
- Superfamily: 1.01.04. Scavenger receptors and related (8 families) PF00059 (Pfam)
- Family: 1.01.04.07. Macrophage mannose receptor (5 proteins)
- Species: Homo sapiens (2303 proteins)
- Localization: Cell membrane (998 proteins)
| MRC1_HUMAN » Macrophage mannose receptor 1 » MMR; C-type lectin domain family 13 member D; | |
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| Hydrophobic Thickness | 34.8 ± 2.4 Å |
| Tilt Angle | 16 ± 3° |
| ΔGtransfer | -18.9 kcal/mol |
| Links to MRC1_HUMAN | UniProtKB, Pfam, iHOP, STRING, PharmGKB, HGNC, Wikipedia, Interpro |
| Topology | Out |
| Domains | AA: 22-143, PDBID: 1fwu, Subunit A, Seq Identity:83%, Ricin-type beta-trefoil lectin domain AA: 168-209, PDBID: 1l6j, Subunit A, Seq Identity:60%, Fibronectin type II domain AA: 236-342, PDBID: 1t8c, Subunit A, Seq Identity:32%, Lectin C-type domain AA: 380-488, PDBID: 1tdq, Subunit B, Seq Identity:38%, Lectin C-type domain AA: 521-627, PDBID: 1t8c, Subunit A, Seq Identity:27%, Lectin C-type domain AA: 669-779, PDBID: 1egg, Subunit B, Seq Identity:100%, Lectin C-type domain AA: 817-924, PDBID: 1t8c, Subunit A, Seq Identity:40%, Lectin C-type domain AA: 966-1081, PDBID: 1t8c, Subunit A, Seq Identity:35%, Lectin C-type domain AA: 1112-1214, PDBID: 1t8c, Subunit A, Seq Identity:29%, Lectin C-type domain AA: 1252-1357, PDBID: 1k9i, Subunit J, Seq Identity:35%, Lectin C-type domain |
| Transmembrane segments |
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| Segments: 1385-1415 |
| Uniprot annotation for MRC1_HUMAN » Macrophage mannose receptor 1 |
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FUNCTION: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. MISCELLANEOUS: CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates. -- Uniprot annotation-- |
| Uniprot features for MRC1_HUMAN » Macrophage mannose receptor 1 |
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SIGNAL 1 18 Potential. CHAIN 19 1456 Macrophage mannose receptor 1. DOMAIN 22 142 Ricin B-type lectin. DOMAIN 163 211 Fibronectin type-II. DOMAIN 225 341 C-type lectin 1. DOMAIN 369 487 C-type lectin 2. DOMAIN 511 626 C-type lectin 3. DOMAIN 655 778 C-type lectin 4. DOMAIN 807 923 C-type lectin 5. DOMAIN 952 1080 C-type lectin 6. DOMAIN 1102 1213 C-type lectin 7. DOMAIN 1241 1356 C-type lectin 8. DISULFID 35 49 By similarity. DISULFID 74 91 By similarity. DISULFID 168 194 By similarity. DISULFID 182 209 By similarity. DISULFID 247 340 By similarity. DISULFID 316 332 By similarity. DISULFID 391 486 By similarity. DISULFID 463 478 By similarity. DISULFID 532 625 By similarity. DISULFID 600 617 By similarity. DISULFID 646 659 DISULFID 680 777 DISULFID 753 769 DISULFID 828 922 By similarity. DISULFID 899 914 By similarity. DISULFID 977 1079 By similarity. DISULFID 1052 1071 By similarity. DISULFID 1123 1212 By similarity. DISULFID 1190 1204 By similarity. DISULFID 1263 1355 By similarity. DISULFID 1332 1347 By similarity. |
