MRC1_HUMAN » Macrophage mannose receptor 1

MRC1_HUMAN » Macrophage mannose receptor 1
Magnify MRC1_HUMAN » Macrophage mannose receptor 1Enlarged view of image
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MRC1_HUMAN » Macrophage mannose receptor 1 » MMR; C-type lectin domain family 13 member D;C-type lectin domain family 13 member D-like;Macrophage mannose receptor 1-like protein 1;
Hydrophobic Thickness 34.0 ± 1.8 Å
Tilt Angle 1 ± 0°
ΔGtransfer -42.3 kcal/mol
ΔGfold -23.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 1387-1411 (1385-1415)
Pathways

Cell cycle - yeast (KEGG)

Immune System (Reactome)

Phagosome (KEGG)

Tuberculosis (KEGG)

PDB 1egg (A/B=644-787), 1egi (A/B=644-787)
OPM none
Complexes

MRC1:MRC1_HUMAN

Interactions

MRC1, Complex: Homodimer of macrophage mannose receptor 1, PDBID: 1EGG

Domains

AA: 23-117, PDBID: 1DQG, Subunit A, Seq Identity:88%, Ricin-type beta-trefoil lectin domain

AA: 168-209, PDBID: 1L6J, Subunit A, Seq Identity:60%, Fibronectin type II domain

AA: 236-342, PDBID: 5AO5, Subunit A, Seq Identity:52%, Lectin C-type domain

AA: 380-488, PDBID: 5AO5, Subunit A, Seq Identity:46%, Lectin C-type domain

AA: 521-627, PDBID: 1T8C, Subunit A, Seq Identity:29%, Lectin C-type domain

AA: 669-779, PDBID: 1EGG, Subunit A, Seq Identity:100%, Lectin C-type domain

AA: 817-924, PDBID: 1T8C, Subunit A, Seq Identity:36%, Lectin C-type domain

AA: 966-1081, PDBID: 1T8C, Subunit A, Seq Identity:35%, Lectin C-type domain

AA: 1112-1214, PDBID: 1T8C, Subunit A, Seq Identity:29%, Lectin C-type domain

AA: 1252-1357, PDBID: 1K9I, Subunit G, Seq Identity:34%, Lectin C-type domain

UniProt annotation for MRC1_HUMAN » Macrophage mannose receptor 1
FUNCTION: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.

MISCELLANEOUS: CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.

UniProt features for MRC1_HUMAN » Macrophage mannose receptor 1
SIGNAL 1 18 Potential.
CHAIN 19 1456 Macrophage mannose receptor 1.
DOMAIN 22 142 Ricin B-type lectin.
DOMAIN 163 211 Fibronectin type-II.
DOMAIN 225 341 C-type lectin 1.
DOMAIN 369 487 C-type lectin 2.
DOMAIN 511 626 C-type lectin 3.
DOMAIN 655 778 C-type lectin 4.
DOMAIN 807 923 C-type lectin 5.
DOMAIN 952 1080 C-type lectin 6.
DOMAIN 1102 1213 C-type lectin 7.
DOMAIN 1241 1356 C-type lectin 8.
DISULFID 35 49 By similarity.
DISULFID 74 91 By similarity.
DISULFID 168 194 By similarity.
DISULFID 182 209 By similarity.
DISULFID 247 340 By similarity.
DISULFID 316 332 By similarity.
DISULFID 391 486 By similarity.
DISULFID 463 478 By similarity.
DISULFID 532 625 By similarity.
DISULFID 600 617 By similarity.
DISULFID 646 659
DISULFID 680 777
DISULFID 753 769
DISULFID 828 922 By similarity.
DISULFID 899 914 By similarity.
DISULFID 977 1079 By similarity.
DISULFID 1052 1071 By similarity.
DISULFID 1123 1212 By similarity.
DISULFID 1190 1204 By similarity.
DISULFID 1263 1355 By similarity.
DISULFID 1332 1347 By similarity.
Amino Acid Sequence for MRC1_HUMAN » Macrophage mannose receptor 1
MRLPLLLVFA SVIPGAVLLL DTRQFLIYNE DHKRCVDAVS PSAVQTAACN QDAESQKFRW VSESQIMSVA FKLCLGVPSK TDWVAITLYA CDSKSEFQKW ECKNDTLLGI KGEDLFFNYG NRQEKNIMLY KGSGLWSRWK IYGTTDNLCS RGYEAMYTLL GNANGATCAF PFKFENKWYA DCTSAGRSDG WLWCGTTTDY DTDKLFGYCP LKFEGSESLW NKDPLTSVSY QINSKSALTW HQARKSCQQQ NAELLSITEI HEQTYLTGLT SSLTSGLWIG LNSLSFNSGW QWSDRSPFRY LNWLPGSPSA EPGKSCVSLN PGKNAKWENL ECVQKLGYIC KKGNTTLNSF VIPSESDVPT HCPSQWWPYA GHCYKIHRDE KKIQRDALTT CRKEGGDLTS IHTIEELDFI ISQLGYEPND ELWIGLNDIK IQMYFEWSDG TPVTFTKWLR GEPSHENNRQ EDCVVMKGKD GYWADRGCEW PLGYICKMKS RSQGPEIVEV EKGCRKGWKK HHFYCYMIGH TLSTFAEANQ TCNNENAYLT TIEDRYEQAF LTSFVGLRPE KYFWTGLSDI QTKGTFQWTI EEEVRFTHWN SDMPGRKPGC VAMRTGIAGG LWDVLKCDEK AKFVCKHWAE GVTHPPKPTT TPEPKCPEDW GASSRTSLCF KLYAKGKHEK KTWFESRDFC RALGGDLASI NNKEEQQTIW RLITASGSYH KLFWLGLTYG SPSEGFTWSD GSPVSYENWA YGEPNNYQNV EYCGELKGDP TMSWNDINCE HLNNWICQIQ KGQTPKPEPT PAPQDNPPVT EDGWVIYKDY QYYFSKEKET MDNARAFCKR NFGDLVSIQS ESEKKFLWKY VNRNDAQSAY FIGLLISLDK KFAWMDGSKV DYVSWATGEP NFANEDENCV TMYSNSGFWN DINCGYPNAF ICQRHNSSIN ATTVMPTMPS VPSGCKEGWN FYSNKCFKIF GFMEEERKNW QEARKACIGF GGNLVSIQNE KEQAFLTYHM KDSTFSAWTG LNDVNSEHTF LWTDGRGVHY TNWGKGYPGG RRSSLSYEDA DCVVIIGGAS NEAGKWMDDT CDSKRGYICQ TRSDPSLTNP PATIQTDGFV KYGKSSYSLM RQKFQWHEAE TYCKLHNSLI ASILDPYSNA FAWLQMETSN ERVWIALNSN LTDNQYTWTD KWRVRYTNWA ADEPKLKSAC VYLDLDGYWK TAHCNESFYF LCKRSDEIPA TEPPQLPGRC PESDHTAWIP FHGHCYYIES SYTRNWGQAS LECLRMGSSL VSIESAAESS FLSYRVEPLK SKTNFWIGLF RNVEGTWLWI NNSPVSFVNW NTGDPSGERN DCVALHASSG FWSNIHCSSY KGYICKRPKI IDAKPTHELL TTKADTRKMD PSKPSSNVAG VVIIVILLIL TGAGLAAYFF YKKRRVHLPQ EGAFENTLYF NSQSSPGTSD MKDLVGNIEQ NEHSVI