MRAP_HUMAN » Melanocortin-2 receptor accessory protein

MRAP_HUMAN » Melanocortin-2 receptor accessory protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MRAP_HUMAN » Melanocortin-2 receptor accessory protein » B27;Fat cell-specific low molecular weight protein;Fat tissue-specific low MW protein;
Hydrophobic Thickness 34.4 ± 2.6 Å
Tilt Angle 2 ± 0°
ΔGtransfer -40.9 kcal/mol
ΔGfold -28.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 37-62 (28-65)
Pathways none
PDB none
OPM none
Complexes none
Interactions

MRAP2, Complex: MRAP:MRAP2, PubMed

Domains

AA: 1-89, Melanocortin-2 receptor accessory protein family

UniProt annotation for MRAP_HUMAN » Melanocortin-2 receptor accessory protein
FUNCTION: Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.

SUBUNIT: Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP2. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R.

TISSUE SPECIFICITY: Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues.

DISEASE: Glucocorticoid deficiency 2 (GCCD2) OMIM: A rare, potentially lethal, autosomal recessive disorder characterized by resistance to ACTH action on the adrenal cortex, adrenal insufficiency and an inability of the adrenal cortex to produce cortisol. It usually presents in the neonatal period or in early childhood with episodes of hypoglycemia and other symptoms related to cortisol deficiency, including failure to thrive, recurrent illnesses or infections, convulsions, and shock. In a small number of patients hypoglycemia can be sufficiently severe and persistent that it leads to serious long-term neurological damage or death. The diagnosis is readily confirmed with a low plasma cortisol measurement in the presence of an elevated ACTH level, and normal aldosterone and plasma renin measurements. mutations affecting the gene represented in this entry.

UniProt features for MRAP_HUMAN » Melanocortin-2 receptor accessory protein
CHAIN 1 172 Melanocortin-2 receptor accessory protein.
Amino Acid Sequence for MRAP_HUMAN » Melanocortin-2 receptor accessory protein
MANGTNASAP YYSYEYYLDY LDLIPVDEKK LKAHKHSIVI AFWVSLAAFV VLLFLILLYM SWSASPQMRN SPKHHQTCPW SHGLNLHLCI QKCLPCHREP LATSQAQASS VEPGSRTGPD QPLRQESSST LPLGGFQTHP TLLWELTLNG GPLVRSKPSE PPPGDRTSQL QS