MRAP2_HUMAN » Melanocortin-2 receptor accessory protein 2

MRAP2_HUMAN » Melanocortin-2 receptor accessory protein 2
Magnify MRAP2_HUMAN » Melanocortin-2 receptor accessory protein 2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MRAP2_HUMAN » Melanocortin-2 receptor accessory protein 2 » MC2R accessory protein 2;
Hydrophobic Thickness 35.6 ± 2.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -56.9 kcal/mol
ΔGfold -27.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 46-69 (35-70)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: MRAP2:A4

MRAP, Complex: MRAP:MRAP2, PubMed

Domains

AA: 13-99, Melanocortin-2 receptor accessory protein family

UniProt annotation for MRAP2_HUMAN » Melanocortin-2 receptor accessory protein 2
FUNCTION: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.

SUBUNIT: Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R.

TISSUE SPECIFICITY: Expressed in the adrenal gland and brain. Not expressed in other tissues.

DISEASE: Obesity (OBESITY) OMIM: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. susceptibility may be associated with variations affecting the gene represented in this entry.

UniProt features for MRAP2_HUMAN » Melanocortin-2 receptor accessory protein 2
CHAIN 1 205 Melanocortin-2 receptor accessory protein 2.
Amino Acid Sequence for MRAP2_HUMAN » Melanocortin-2 receptor accessory protein 2
MSAQRLISNR TSQQSASNSD YTWEYEYYEI GPVSFEGLKA HKYSIVIGFW VGLAVFVIFM FFVLTLLTKT GAPHQDNAES SEKRFRMNSF VSDFGRPLEP DKVFSRQGNE ESRSLFHCYI NEVERLDRAK ACHQTTALDS DVQLQEAIRS SGQPEEELNR LMKFDIPNFV NTDQNYFGED DLLISEPPIV LETKPLSQTS HKDLD