MPZL2_HUMAN » Myelin protein zero-like protein 2

MPZL2_HUMAN » Myelin protein zero-like protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MPZL2_HUMAN » Myelin protein zero-like protein 2 » Epithelial V-like antigen 1;
Hydrophobic Thickness 35.2 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -55.8 kcal/mol
ΔGfold -27.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 153-178 (149-181)
Pathways none
PDB none
OPM none
Complexes none
Interactions

MPZL3, Complex: MPZL2:MPZL3

Domains

AA: 30-143, PDBID: 1NEU, Subunit A, Seq Identity:36%, Immunoglobulin V-set domain

UniProt annotation for MPZL2_HUMAN » Myelin protein zero-like protein 2
FUNCTION: Mediates homophilic cell-cell adhesion.

TISSUE SPECIFICITY: Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias.

UniProt features for MPZL2_HUMAN » Myelin protein zero-like protein 2
SIGNAL 1 26 Potential.
CHAIN 27 215 Myelin protein zero-like protein 2.
DOMAIN 27 141 Ig-like V-type.
DISULFID 47 123 By similarity.
Amino Acid Sequence for MPZL2_HUMAN » Myelin protein zero-like protein 2
MYGKSSTRAV LLLLGIQLTA LWPIAAVEIY TSRVLEAVNG TDARLKCTFS SFAPVGDALT VTWNFRPLDG GPEQFVFYYH IDPFQPMSGR FKDRVSWDGN PERYDASILL WKLQFDDNGT YTCQVKNPPD VDGVIGEIRL SVVHTVRFSE IHFLALAIGS ACALMIIIVI VVVLFQHYRK KRWAERAHKV VEIKSKEEER LNQEKKVSVY LEDTD