MPZL1_HUMAN » Myelin protein zero-like protein 1

MPZL1_HUMAN » Myelin protein zero-like protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MPZL1_HUMAN » Myelin protein zero-like protein 1 » Protein zero-related;
Hydrophobic Thickness 36.8 ± 1.4 Å
Tilt Angle 3 ± 3°
ΔGtransfer -47.4 kcal/mol
ΔGfold -24.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 162-190 (162-194)
Pathways

Cell adhesion molecules (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 41-155, PDBID: 1NEU, Subunit A, Seq Identity:43%, Immunoglobulin V-set domain

UniProt annotation for MPZL1_HUMAN » Myelin protein zero-like protein 1
FUNCTION: Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine- protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.

SUBUNIT: Interacts with phosphorylated PTPN11/SHP-2.

TISSUE SPECIFICITY: Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbilical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line.

DOMAIN: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for MPZL1_HUMAN » Myelin protein zero-like protein 1
SIGNAL 1 35 Potential.
CHAIN 36 269 Myelin protein zero-like protein 1.
DOMAIN 36 146 Ig-like V-type.
MOTIF 239 244 ITIM motif 1.
MOTIF 261 266 ITIM motif 2.
DISULFID 58 135 By similarity.
Amino Acid Sequence for MPZL1_HUMAN » Myelin protein zero-like protein 1
MAASAGAGAV IAAPDSRRWL WSVLAAALGL LTAGVSALEV YTPKEIFVAN GTQGKLTCKF KSTSTTGGLT SVSWSFQPEG ADTTVSFFHY SQGQVYLGNY PPFKDRISWA GDLDKKDASI NIENMQFIHN GTYICDVKNP PDIVVQPGHI RLYVVEKENL PVFPVWVVVG IVTAVVLGLT LLISMILAVL YRRKNSKRDY TGCSTSESLS PVKQAPRKSP SDTEGLVKSL PSGSHQGPVI YAQLDHSGGH HSDKINKSES VVYADIRKN