MPS3_YEAST » Spindle pole body assembly component MPS3

MPS3_YEAST » Spindle pole body assembly component MPS3
Magnify MPS3_YEAST » Spindle pole body assembly component MPS3Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Nuclear inner membrane
Topologyintermembrane space
nucleus matrix side
MPS3_YEAST » Spindle pole body assembly component MPS3 » 98 kDa nuclear envelope protein;Monopolar spindle protein 3;
Hydrophobic Thickness 32.8 ± 3.0 Å
Tilt Angle 12 ± 10°
ΔGtransfer -23.3 kcal/mol
ΔGfold -15.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 154-176 (143-176)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ALG14, Complex: ALG14:MPS3, PubMed

CSM4, Complex: MPS3:CSM4, PubMed

ERP3, Complex: ERP3:MPS3

KTR5, Complex: MPS3:KTR5, PubMed

KTR7, Complex: MPS3:KTR7, PubMed

MPS2, Complex: MPS2:MPS3, PubMed

NEM1, Complex: NEM1:MPS3

PSD1, Complex: PSD1:MPS3

SEC20, Complex: MPS3:SEC20, PubMed

SLP1, Complex: SLP1:MPS3

Domains none
UniProt annotation for MPS3_YEAST » Spindle pole body assembly component MPS3
FUNCTION: Required for the first step of spindle pole body duplication in G1. Essential for nuclear division and fusion. Functions in sister chromatid cohesion establishment. Connects the spindle pole body with the nuclear envelope through its interaction with MPS2 and mediates meiotic bouquet formation and rapid chromosome movements in meiotic prophase. Functions as an integral membrane anchor for telomeres and is a nuclear receptor for the SIR4 pathway of telomere tethering and gene inactivation. recruits double-strand breaks (DSBs) to the nuclear periphery for chromosome healing.

SUBUNIT: Interacts with CSM4; ECO1, EST1, JEM1, CDC31, NDJ1, MPS2 and SIR4.

DOMAIN: The SUN domain is involved in the binding to MPS2.

UniProt features for MPS3_YEAST » Spindle pole body assembly component MPS3
CHAIN 1 682 Spindle pole body assembly component MPS3.
DOMAIN 427 616 SUN.
REGION 171 682 Interaction with CDC31.
REGION 431 650 Interaction with JEM1.
COILED 241 273 Potential.
Amino Acid Sequence for MPS3_YEAST » Spindle pole body assembly component MPS3
MNNSNEHRRE EAGAANEQMP YNKAVKSAYA DVLKDKMNRE QEISLRAIKK GIYTDGGETD NYDMDKENDS AYEMFKKNLD FPLDQHNDDD DDDPYIEDNG QETDGYSDED YTDEADKSFI EDSDSDSYDL ESNSDFEENL ESSGEAKKLK WRTYIFYGGL FFVFYFFGSF LMTTVKNNDL ESHSSGATSS PGKSFSNLQK QVNHLYSELS KRDEKHSSEL DKTVKIIVSQ FEKNIKRLLP SNLVNFENDI NSLTKQVETI STSMSELQRR NHKFTVENVT QWQDQLVKQL DTHLPQEIPV VINNSSSLLI IPELHNYLSA LISDVIESPG IGTAGSAESR WEYDLNRYVK EILSNELQYI DKDYFIQEMN RRLQSNKQEI WEEITNRLET QQQQQQQQVQ QDYSNVPQQY SSILMKRLIH QIYNSNQHQW EDDLDFATYV QGTKLLNHLT SPTWRQGSGV QPIELLTDSK QSSSTYWQCE NEPGCSWAIR FKTPLYLTKI SYMHGRFTNN LHIMNSAPRL ISLYVKLSQT KEIKALQTLA NQYGFGQHHK RDRNYIKIAK FEYRLTDSRI RQQMYLPPWF IQLKPLVRSI VFQVDENYGN KKFISLRKFI INGVTPQDLQ IIENNEFPVL LGDTPEYGVT QNTDEGKRKV LLSKPPYASS STSTKFHPAS NVPSFGQDEL DQ