MPRI_HUMAN » Cation-independent mannose-6-phosphate receptor

MPRI_HUMAN » Cation-independent mannose-6-phosphate receptor
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Topology in Lysosomal membrane
Topologylysosome lumenal side
cytoplasmic side
MPRI_HUMAN » Cation-independent mannose-6-phosphate receptor » CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor;MPR 300; Insulin-like growth factor 2 receptor;Insulin-like growth factor II receptor;IGF-II receptor; M6P/IGF2 receptor;M6P/IGF2R;
Hydrophobic Thickness 34.0 ± 2.2 Å
Tilt Angle 2 ± 0°
ΔGtransfer -38.4 kcal/mol
ΔGfold -21.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 2303-2330 (2299-2333)
Pathways

Lysosome (KEGG)

Membrane Trafficking (Reactome)

PDB 2l2a (1508-1647), 2m68 (1508-1647), 1e6f (1508-1650), 1gp0 (1508-1650), 1gp3 (1508-1650), 1gqb (1508-1650), 2cnj (1508-1650), 2v5n (1508-1799), 2v5o (1508-2128), 2v5p (A/B=1508-1992), 2l29 (A=1508-1647), 1jwg (C/D=2479-2491), 1jpl (E/F/G/H=2480-2491), 1lf8 (E/F/G/H=2480-2491)
OPM none
Complexes

MPRI:MPRI_BOVIN

Interactions

MPRI, Complex: Homodimer of cation-independent mannose-6-phosphate receptor, PDBID: 1SYO

TGON2, Complex: MPRI:TGON2, PubMed

VCAM1, Complex: MPRI:VCAM1

Domains

AA: 123-270, PDBID: 1Q25, Subunit A, Seq Identity:78%, Cation-independent mannose-6-phosphate receptor repeat

AA: 277-421, PDBID: 1Q25, Subunit A, Seq Identity:66%, Cation-independent mannose-6-phosphate receptor repeat

AA: 423-573, PDBID: 1Q25, Subunit A, Seq Identity:85%, Cation-independent mannose-6-phosphate receptor repeat

AA: 575-716, PDBID: 2KVA, Subunit A, Seq Identity:82%, Cation-independent mannose-6-phosphate receptor repeat

AA: 720-876, PDBID: 2KVA, Subunit A, Seq Identity:79%, Cation-independent mannose-6-phosphate receptor repeat

AA: 882-1026, PDBID: 2V5N, Subunit A, Seq Identity:25%, Cation-independent mannose-6-phosphate receptor repeat

AA: 1031-1178, PDBID: 2KVA, Subunit A, Seq Identity:28%, Cation-independent mannose-6-phosphate receptor repeat

AA: 1179-1320, PDBID: 2KVA, Subunit A, Seq Identity:31%, Cation-independent mannose-6-phosphate receptor repeat

AA: 1322-1462, PDBID: 1Q25, Subunit A, Seq Identity:36%, Cation-independent mannose-6-phosphate receptor repeat

AA: 1465-1599, PDBID: 1E6F, Subunit A, Seq Identity:100%, Cation-independent mannose-6-phosphate receptor repeat

AA: 1603-1750, PDBID: 1E6F, Subunit A, Seq Identity:100%, Cation-independent mannose-6-phosphate receptor repeat

AA: 1755-1894, PDBID: 2V5N, Subunit A, Seq Identity:100%, Cation-independent mannose-6-phosphate receptor repeat

AA: 1903-1942, PDBID: 2V5O, Subunit A, Seq Identity:100%, Fibronectin type II domain

AA: 1946-2083, PDBID: 2V5O, Subunit A, Seq Identity:100%, Cation-independent mannose-6-phosphate receptor repeat

AA: 2085-2233, PDBID: 2V5O, Subunit A, Seq Identity:100%, Cation-independent mannose-6-phosphate receptor repeat

AA: 2237-2290, PDBID: 1E6F, Subunit A, Seq Identity:20%, Cation-independent mannose-6-phosphate receptor repeat

UniProt annotation for MPRI_HUMAN » Cation-independent mannose-6-phosphate receptor
FUNCTION: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

SUBUNIT: Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3.

DOMAIN: Contains 15 repeating units of approximately 147 AA harboring four disulfide bonds each. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends.

UniProt features for MPRI_HUMAN » Cation-independent mannose-6-phosphate receptor
SIGNAL 1 40
CHAIN 41 2491 Cation-independent mannose-6-phosphate receptor.
REPEAT 40 189 1.
REPEAT 190 344 2.
REPEAT 345 489 3.
REPEAT 490 643 4.
REPEAT 644 783 5.
REPEAT 784 950 6.
REPEAT 951 1099 7.
REPEAT 1100 1243 8.
REPEAT 1244 1384 9.
REPEAT 1385 1532 10.
REPEAT 1533 1666 11.
REPEAT 1667 1820 12.
REPEAT 1821 2008 13.
DOMAIN 1898 1944 Fibronectin type-II.
REPEAT 2009 2137 14.
REPEAT 2165 2289 15.
DISULFID 49 69 By similarity.
DISULFID 77 84 By similarity.
DISULFID 117 149 By similarity.
DISULFID 134 161 By similarity.
DISULFID 174 212 By similarity.
DISULFID 228 235 By similarity.
DISULFID 275 306 By similarity.
DISULFID 288 318 By similarity.
DISULFID 328 366 By similarity.
DISULFID 374 382 By similarity.
DISULFID 420 454 By similarity.
DISULFID 434 466 By similarity.
DISULFID 627 664 By similarity.
DISULFID 672 679 By similarity.
DISULFID 731 760 By similarity.
DISULFID 1516 1553
DISULFID 1559 1566
DISULFID 1598 1634
DISULFID 1614 1646
DISULFID 1652 1695
DISULFID 1706 1713
DISULFID 1750 1783
DISULFID 1766 1795
DISULFID 1804 1839
DISULFID 1850 1856
DISULFID 1893 1975
DISULFID 1903 1927
DISULFID 1917 1942
DISULFID 1957 1987
DISULFID 1994 2029
DISULFID 2039 2046
DISULFID 2082 2113
DISULFID 2096 2125
Amino Acid Sequence for MPRI_HUMAN » Cation-independent mannose-6-phosphate receptor
MGAAAGRSPH LGPAPARRPQ RSLLLLQLLL LVAAPGSTQA QAAPFPELCS YTWEAVDTKN NVLYKINICG SVDIVQCGPS SAVCMHDLKT RTYHSVGDSV LRSATRSLLE FNTTVSCDQQ GTNHRVQSSI AFLCGKTLGT PEFVTATECV HYFEWRTTAA CKKDIFKANK EVPCYVFDEE LRKHDLNPLI KLSGAYLVDD SDPDTSLFIN VCRDIDTLRD PGSQLRACPP GTAACLVRGH QAFDVGQPRD GLKLVRKDRL VLSYVREEAG KLDFCDGHSP AVTITFVCPS ERREGTIPKL TAKSNCRYEI EWITEYACHR DYLESKTCSL SGEQQDVSID LTPLAQSGGS SYISDGKEYL FYLNVCGETE IQFCNKKQAA VCQVKKSDTS QVKAAGRYHN QTLRYSDGDL TLIYFGGDEC SSGFQRMSVI NFECNKTAGN DGKGTPVFTG EVDCTYFFTW DTEYACVKEK EDLLCGATDG KKRYDLSALV RHAEPEQNWE AVDGSQTETE KKHFFINICH RVLQEGKARG CPEDAAVCAV DKNGSKNLGK FISSPMKEKG NIQLSYSDGD DCGHGKKIKT NITLVCKPGD LESAPVLRTS GEGGCFYEFE WHTAAACVLS KTEGENCTVF DSQAGFSFDL SPLTKKNGAY KVETKKYDFY INVCGPVSVS PCQPDSGACQ VAKSDEKTWN LGLSNAKLSY YDGMIQLNYR GGTPYNNERH TPRATLITFL CDRDAGVGFP EYQEEDNSTY NFRWYTSYAC PEEPLECVVT DPSTLEQYDL SSLAKSEGGL GGNWYAMDNS GEHVTWRKYY INVCRPLNPV PGCNRYASAC QMKYEKDQGS FTEVVSISNL GMAKTGPVVE DSGSLLLEYV NGSACTTSDG RQTTYTTRIH LVCSRGRLNS HPIFSLNWEC VVSFLWNTEA ACPIQTTTDT DQACSIRDPN SGFVFNLNPL NSSQGYNVSG IGKIFMFNVC GTMPVCGTIL GKPASGCEAE TQTEELKNWK PARPVGIEKS LQLSTEGFIT LTYKGPLSAK GTADAFIVRF VCNDDVYSGP LKFLHQDIDS GQGIRNTYFE FETALACVPS PVDCQVTDLA GNEYDLTGLS TVRKPWTAVD TSVDGRKRTF YLSVCNPLPY IPGCQGSAVG SCLVSEGNSW NLGVVQMSPQ AAANGSLSIM YVNGDKCGNQ RFSTRITFEC AQISGSPAFQ LQDGCEYVFI WRTVEACPVV RVEGDNCEVK DPRHGNLYDL KPLGLNDTIV SAGEYTYYFR VCGKLSSDVC PTSDKSKVVS SCQEKREPQG FHKVAGLLTQ KLTYENGLLK MNFTGGDTCH KVYQRSTAIF FYCDRGTQRP VFLKETSDCS YLFEWRTQYA CPPFDLTECS FKDGAGNSFD LSSLSRYSDN WEAITGTGDP EHYLINVCKS LAPQAGTEPC PPEAAACLLG GSKPVNLGRV RDGPQWRDGI IVLKYVDGDL CPDGIRKKST TIRFTCSESQ VNSRPMFISA VEDCEYTFAW PTATACPMKS NEHDDCQVTN PSTGHLFDLS SLSGRAGFTA AYSEKGLVYM SICGENENCP PGVGACFGQT RISVGKANKR LRYVDQVLQL VYKDGSPCPS KSGLSYKSVI SFVCRPEAGP TNRPMLISLD KQTCTLFFSW HTPLACEQAT ECSVRNGSSI VDLSPLIHRT GGYEAYDESE DDASDTNPDF YINICQPLNP MHGVPCPAGA AVCKVPIDGP PIDIGRVAGP PILNPIANEI YLNFESSTPC LADKHFNYTS LIAFHCKRGV SMGTPKLLRT SECDFVFEWE TPVVCPDEVR MDGCTLTDEQ LLYSFNLSSL STSTFKVTRD SRTYSVGVCT FAVGPEQGGC KDGGVCLLSG TKGASFGRLQ SMKLDYRHQD EAVVLSYVNG DRCPPETDDG VPCVFPFIFN GKSYEECIIE SRAKLWCSTT ADYDRDHEWG FCRHSNSYRT SSIIFKCDED EDIGRPQVFS EVRGCDVTFE WKTKVVCPPK KLECKFVQKH KTYDLRLLSS LTGSWSLVHN GVSYYINLCQ KIYKGPLGCS ERASICRRTT TGDVQVLGLV HTQKLGVIGD KVVVTYSKGY PCGGNKTASS VIELTCTKTV GRPAFKRFDI DSCTYYFSWD SRAACAVKPQ EVQMVNGTIT NPINGKSFSL GDIYFKLFRA SGDMRTNGDN YLYEIQLSSI TSSRNPACSG ANICQVKPND QHFSRKVGTS DKTKYYLQDG DLDVVFASSS KCGKDKTKSV SSTIFFHCDP LVEDGIPEFS HETADCQYLF SWYTSAVCPL GVGFDSENPG DDGQMHKGLS ERSQAVGAVL SLLLVALTCC LLALLLYKKE RRETVISKLT TCCRRSSNVS YKYSKVNKEE ETDENETEWL MEEIQLPPPR QGKEGQENGH ITTKSVKALS SLHGDDQDSE DEVLTIPEVK VHSGRGAGAE SSHPVRNAQS NALQEREDDR VGLVRGEKAR KGKSSSAQQK TVSSTKLVSF HDDSDEDLLH I