MPRD_HUMAN » Cation-dependent mannose-6-phosphate receptor

MPRD_HUMAN » Cation-dependent mannose-6-phosphate receptor
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Topology in Lysosomal membrane
Topologylysosome lumenal side
cytoplasmic side
MPRD_HUMAN » Cation-dependent mannose-6-phosphate receptor » CD Man-6-P receptor; CD-MPR; 46 kDa mannose 6-phosphate receptor;MPR 46;
Hydrophobic Thickness 37.2 ± 2.0 Å
Tilt Angle 3 ± 2°
ΔGtransfer -36.3 kcal/mol
ΔGfold -16.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 185-210 (181-218)
Pathways

Lysosome (KEGG)

Membrane Trafficking (Reactome)

Phagosome (KEGG)

PDB 1juq (E/F/G/H=265-277)
OPM none
Complexes

MPRD:MPRD_BOVIN

Interactions

LRP2, Complex: MPRD:LRP2

MPRD, Complex: Homodimer of cation-dependent mannose-6-phosphate receptor, PDBID: 2RL8

NDUB4, Complex: NDUB4:MPRD, PubMed

OLR1, Complex: MPRD:OLR1

PPAL, Complex: PPAL:MPRD, PubMed

Domains

AA: 1-277, PDBID: 1C39, Subunit A, Seq Identity:92%, Mannose-6-phosphate receptor

UniProt annotation for MPRD_HUMAN » Cation-dependent mannose-6-phosphate receptor
FUNCTION: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

SUBUNIT: Homodimer. Binds GGA1, GGA2 and GGA3.

DOMAIN: The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.

MISCELLANEOUS: This receptor has optimal binding in the presence of divalent cations.

UniProt features for MPRD_HUMAN » Cation-dependent mannose-6-phosphate receptor
SIGNAL 1 26
CHAIN 27 277 Cation-dependent mannose-6-phosphate receptor.
Amino Acid Sequence for MPRD_HUMAN » Cation-dependent mannose-6-phosphate receptor
MFPFYSCWRT GLLLLLLAVA VRESWQTEEK TCDLVGEKGK ESEKELALVK RLKPLFNKSF ESTVGQGSDT YIYIFRVCRE AGNHTSGAGL VQINKSNGKE TVVGRLNETH IFNGSNWIML IYKGGDEYDN HCGKEQRRAV VMISCNRHTL ADNFNPVSEE RGKVQDCFYL FEMDSSLACS PEISHLSVGS ILLVTFASLV AVYVVGGFLY QRLVVGAKGM EQFPHLAFWQ DLGNLVADGC DFVCRSKPRN VPAAYRGVGD DQLGEESEER DDHLLPM