|MOG_HUMAN » Myelin-oligodendrocyte glycoprotein »|
|Hydrophobic Thickness||36.4 ± 2.4 Å|
|Tilt Angle||9 ± 11°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||205-230 (205-236)|
triacylglycerol biosynthesis (BioCyc)
|UniProt annotation for MOG_HUMAN » Myelin-oligodendrocyte glycoprotein|
|FUNCTION: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication. SUBUNIT: Homodimer (By similarity). May form heterodimers between the different isoforms. TISSUE SPECIFICITY: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes. DISEASE: Narcolepsy 7 (NRCLP7) OMIM: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye- movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. caused by mutations affecting the gene represented in this entry.|
|UniProt features for MOG_HUMAN » Myelin-oligodendrocyte glycoprotein|
SIGNAL 1 29 Potential. |
CHAIN 30 247 Myelin-oligodendrocyte glycoprotein.
DOMAIN 32 145 Ig-like V-type.
DISULFID 53 127 Potential.
|Amino Acid Sequence for MOG_HUMAN » Myelin-oligodendrocyte glycoprotein|
|MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS DEGGFTCFFR DHSYQEEAAM ELKVEDPFYW VSPGVLVLLA VLPVLLLQIT VGLIFLCLQY RLRGKLRAEI ENLHRTFDPH FLRVPCWKIT LFVIVPVLGP LVALIICYNW LHRRLAGQFL EELRNPF|