MOG_HUMAN » Myelin-oligodendrocyte glycoprotein

MOG_HUMAN » Myelin-oligodendrocyte glycoprotein
Magnify MOG_HUMAN » Myelin-oligodendrocyte glycoproteinEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MOG_HUMAN » Myelin-oligodendrocyte glycoprotein »
Hydrophobic Thickness 36.4 ± 2.4 Å
Tilt Angle 9 ± 11°
ΔGtransfer -27.8 kcal/mol
ΔGfold -16.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 205-230 (205-236)
Pathways

triacylglycerol biosynthesis (BioCyc)

PDB none
OPM none
Complexes none
Interactions

APRIO, Complex: APRIO.PRIO:MOG, PubMed

Domains

AA: 36-145, PDBID: 1PKO, Subunit A, Seq Identity:87%, Immunoglobulin V-set domain

UniProt annotation for MOG_HUMAN » Myelin-oligodendrocyte glycoprotein
FUNCTION: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication.

SUBUNIT: Homodimer (By similarity). May form heterodimers between the different isoforms.

TISSUE SPECIFICITY: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.

DISEASE: Narcolepsy 7 (NRCLP7) OMIM: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye- movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. caused by mutations affecting the gene represented in this entry.

UniProt features for MOG_HUMAN » Myelin-oligodendrocyte glycoprotein
SIGNAL 1 29 Potential.
CHAIN 30 247 Myelin-oligodendrocyte glycoprotein.
DOMAIN 32 145 Ig-like V-type.
DISULFID 53 127 Potential.
Amino Acid Sequence for MOG_HUMAN » Myelin-oligodendrocyte glycoprotein
MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS DEGGFTCFFR DHSYQEEAAM ELKVEDPFYW VSPGVLVLLA VLPVLLLQIT VGLIFLCLQY RLRGKLRAEI ENLHRTFDPH FLRVPCWKIT LFVIVPVLGP LVALIICYNW LHRRLAGQFL EELRNPF