MO2R1_HUMAN » Cell surface glycoprotein CD200 receptor 1

MO2R1_HUMAN » Cell surface glycoprotein CD200 receptor 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MO2R1_HUMAN » Cell surface glycoprotein CD200 receptor 1 » CD200 cell surface glycoprotein receptor;Cell surface glycoprotein OX2 receptor 1;
Hydrophobic Thickness 34.2 ± 1.3 Å
Tilt Angle 7 ± 7°
ΔGtransfer -24.0 kcal/mol
ΔGfold -19.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 244-266 (244-270)
Pathways

Immune System (Reactome)

PDB none
OPM none
Complexes

OX2G:MO2R1_MOUSE

Interactions

OX2G, Complex: MO2R1:OX2G, PDBID: 4bfi, PubMed

Domains

AA: 148-226, PDBID: 4BFG, Subunit A, Seq Identity:63%, CD80-like C2-set immunoglobulin domain

UniProt annotation for MO2R1_HUMAN » Cell surface glycoprotein CD200 receptor 1
FUNCTION: Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.

SUBUNIT: CD200 and CD200R1 interact via their respective N- terminal Ig-like domains (By similarity). Interacts with Human herpesvirus 8 vOX2 protein.

TISSUE SPECIFICITY: Expressed in granulocytes, monocytes, most T- cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.

UniProt features for MO2R1_HUMAN » Cell surface glycoprotein CD200 receptor 1
SIGNAL 1 28 Potential.
CHAIN 29 325 Cell surface glycoprotein CD200 receptor 1.
DOMAIN 53 139 Ig-like V-type.
DOMAIN 140 228 Ig-like C2-type.
DISULFID 60 132 Potential.
DISULFID 167 216 Potential.
Amino Acid Sequence for MO2R1_HUMAN » Cell surface glycoprotein CD200 receptor 1
MLCPWRTANL GLLLILTIFL VAASSSLCMD EKQITQNYSK VLAEVNTSWP VKMATNAVLC CPPIALRNLI IITWEIILRG QPSCTKAYRK ETNETKETNC TDERITWVSR PDQNSDLQIR PVAITHDGYY RCIMVTPDGN FHRGYHLQVL VTPEVTLFQN RNRTAVCKAV AGKPAAQISW IPEGDCATKQ EYWSNGTVTV KSTCHWEVHN VSTVTCHVSH LTGNKSLYIE LLPVPGAKKS AKLYIPYIIL TIIILTIVGF IWLLKVNGCR KYKLNKTEST PVVEEDEMQP YASYTEKNNP LYDTTNKVKA SEALQSEVDT DLHTL