MILR1_HUMAN » Allergin-1

MILR1_HUMAN » Allergin-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MILR1_HUMAN » Allergin-1 » Allergy inhibitory receptor 1;Mast cell antigen 32;MCA-32; Mast cell immunoglobulin-like receptor 1;
Hydrophobic Thickness 37.2 ± 4.4 Å
Tilt Angle 26 ± 1°
ΔGtransfer -37.3 kcal/mol
ΔGfold -27.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 224-252 (223-258)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 36-121, PDBID: 5CJ8, Subunit A, Seq Identity:20%, Immunoglobulin domain
UniProt annotation for MILR1_HUMAN » Allergin-1
FUNCTION: Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE- mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).

SUBUNIT: Monomer. Interacts (tyrosine-phosphorylated) with PTPN6, PTPN11 and INPP5D.

TISSUE SPECIFICITY: Expressed in myeloid cells (dendritic cells, macrophages and neutrophils, weak expression on B-cells but not in T-cells or natural killer cells), peripheral blood basophils and mast cells (at protein level).

UniProt features for MILR1_HUMAN » Allergin-1
SIGNAL 1 19 Potential.
CHAIN 20 343 Allergin-1.
DOMAIN 35 118 Ig-like C2-type 1.
DOMAIN 128 213 Ig-like C2-type 2.
MOTIF 311 316 ITIM motif.
MOTIF 336 341 ITIM motif.
DISULFID 56 103 By similarity.
DISULFID 147 196 By similarity.
Amino Acid Sequence for MILR1_HUMAN » Allergin-1
MWSHLNRLLF WSIFSSVTCR KAVLDCEAMK TNEFPSPCLD SKTKVVMKGQ NVSMFCSHKN KSLQITYSLF RRKTHLGTQD GKGEPAIFNL SITEAHESGP YKCKAQVTSC SKYSRDFSFT IVDPVTSPVL NIMVIQTETD RHITLHCLSV NGSLPINYTF FENHVAISPA ISKYDREPAE FNLTKKNPGE EEEYRCEAKN RLPNYATYSH PVTMPSTGGD SCPFCLKLLL PGLLLLLVVI ILILAFWVLP KYKTRKAMRN NVPRDRGDTA MEVGIYANIL EKQAKEESVP EVGSRPCVST AQDEAKHSQE LQYATPVFQE VAPREQEACD SYKSGYVYSE LNF