MID51_HUMAN » Mitochondrial dynamic protein MID51

MID51_HUMAN » Mitochondrial dynamic protein MID51
Magnify MID51_HUMAN » Mitochondrial dynamic protein MID51Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Mitochondrial outer membrane
Topologyintermembrane space
cytoplasmic side
MID51_HUMAN » Mitochondrial dynamic protein MID51 » Mitochondrial dynamic protein of 51 kDa;Mitochondrial elongation factor 1;Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like;
Hydrophobic Thickness 26.8 ± 3.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -23.6 kcal/mol
ΔGfold -10.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 29-50 (26-53)
Pathways none
PDB 4nxt (119-463), 4nxw (119-463), 4nxx (119-463), 4nxu (A/B/C/D=119-463), 4nxv (A/B/C/D=119-463)
OPM none
Complexes

MID51:MID51_HUMAN

Interactions

FIS1, Complex: MID51:FIS1, PubMed

MID51, Complex: Homodimer of mitochondrial dynamic protein MID51, PDBID: 4NXU

TOM20, Complex: TOM20:MID51, PubMed

Domains

AA: 190-451, PDBID: 4NXT, Subunit D, Seq Identity:100%, Mab-21 protein

UniProt annotation for MID51_HUMAN » Mitochondrial dynamic protein MID51
FUNCTION: Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.

SUBUNIT: Homodimer. Interacts with DNM1L.

TISSUE SPECIFICITY: Expression is relatively high in heart, skeletal muscle, pancreas and kidney.

UniProt features for MID51_HUMAN » Mitochondrial dynamic protein MID51
CHAIN 1 463 Mitochondrial dynamic protein MID51.
REGION 49 195 Dimerization.
REGION 160 169 Interaction with DNM1L.
Amino Acid Sequence for MID51_HUMAN » Mitochondrial dynamic protein MID51
MAGAGERKGK KDDNGIGTAI DFVLSNARLV LGVGGAAMLG IATLAVKRMY DRAISAPTSP TRLSHSGKRS WEEPNWMGSP RLLNRDMKTG LSRSLQTLPT DSSTFDTDTF CPPRPKPVAR KGQVDLKKSR LRMSLQEKLL TYYRNRAAIP AGEQARAKQA AVDICAELRS FLRAKLPDMP LRDMYLSGSL YDDLQVVTAD HIQLIVPLVL EQNLWSCIPG EDTIMNVPGF FLVRRENPEY FPRGSSYWDR CVVGGYLSPK TVADTFEKVV AGSINWPAIG SLLDYVIRPA PPPEALTLEV QYERDKHLFI DFLPSVTLGD TVLVAKPHRL AQYDNLWRLS LRPAETARLR ALDQADSGCR SLCLKILKAI CKSTPALGHL TASQLTNVIL HLAQEEADWS PDMLADRFLQ ALRGLISYLE AGVLPSALNP KVNLFAELTP EEIDELGYTL YCSLSEPEVL LQT