MID2_YEAST » Cell wall integrity sensor MID2

MID2_YEAST » Cell wall integrity sensor MID2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MID2_YEAST » Cell wall integrity sensor MID2 » Mating pheromone-induced death protein 2;Protein kinase A interference protein 1;Serine-rich multicopy suppressor protein 1;
Hydrophobic Thickness 37.6 ± 3.0 Å
Tilt Angle 14 ± 6°
ΔGtransfer -26.4 kcal/mol
ΔGfold -18.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 225-250 (225-254)
Pathways

MAPK signaling pathway - yeast (KEGG)

PDB none
OPM none
Complexes none
Interactions

ANP1, Complex: MID2:ANP1

CP51, Complex: CP51:MID2, PubMed

CSF1, Complex: CSF1:MID2

GPI8, Complex: GPI8:MID2

HKR1, Complex: HKR1:MID2

HOC1, Complex: HOC1:MID2

KRE6, Complex: KRE6:MID2

MNN10, Complex: MNN10:MID2

MNN11, Complex: MNN11:MID2

MTL1, Complex: MID2:MTL1, PubMed

PEP12, Complex: PEP12:MID2

PIN2, Complex: MID2:PIN2, PubMed

SEC66, Complex: MID2:SEC66

SLG1, Complex: MID2:SLG1, PubMed

VAN1, Complex: MID2:VAN1

WSC2, Complex: MID2:WSC2, PubMed

WSC3, Complex: MID2:WSC3, PubMed

YNS1, Complex: YNS1:MID2

Domains

AA: 178-329, Mid2 like cell wall stress sensor

UniProt annotation for MID2_YEAST » Cell wall integrity sensor MID2
FUNCTION: Cell wall stress sensor. Involved in activation of a response that includes both stress-related increased chitin synthesis and the MPK1 mitogen-activated protein kinase cell integrity pathway. High-copy activator of the SKN7 transcription factor. Required during induction of MPK1 tyrosine phosphorylation under a variety of stress conditions. Required for PKC pathway activation under low pH conditions. Required for cell integrity signaling during pheromone-induced morphogenesis. Activates ROM1 or ROM2 catalyzed guanine nucleotide exchange toward RHO1 in cell wall integrity signaling.

SUBUNIT: Interacts with ZEO1.

UniProt features for MID2_YEAST » Cell wall integrity sensor MID2
SIGNAL 1 25 Potential.
CHAIN 26 376 Cell wall integrity sensor MID2.
Amino Acid Sequence for MID2_YEAST » Cell wall integrity sensor MID2
MLSFTTKNSF RLLLLILSCI STIRAQFFVQ SSSSNSSAVS TARSSVSRVS SSSSILSSSM VSSSSADSSS LTSSTSSRSL VSHTSSSTSI ASISFTSFSF SSDSSTSSSS SASSDSSSSS SFSISSTSAT SESSTSSTQT STSSSSSLSS TPSSSSSPST ITSAPSTSST PSTTAYNQGS TITSIINGKT ILSNHYTTVT YTPSATADSS NKSKSSGLSK KNRNIVIGCV VGIGVPLILV ILALIYMFCI QSSRTDFIDS DGKVVTAYRA NKFTKWWYML LGKKVSDEYH SDSPLGGSAS SAGGLDLDEA DDVMEQSSLF DVRIRDSDSV LPNANTADHN NTNSGGEPIN SSVASNDIIE EKFYDEQGNE LSPRNY