MEGF8_HUMAN » Multiple epidermal growth factor-like domains protein 8

MEGF8_HUMAN » Multiple epidermal growth factor-like domains protein 8
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
MEGF8_HUMAN » Multiple epidermal growth factor-like domains protein 8 » Multiple EGF-like domains protein 8; Epidermal growth factor-like protein 4;EGF-like protein 4;
Hydrophobic Thickness 35.6 ± 1.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -46.1 kcal/mol
ΔGfold -22.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 2647-2672 (2641-2674)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 30-137, PDBID: 1SZB, Subunit A, Seq Identity:28%, CUB domain

AA: 227-277, Galactose oxidase, central domain

AA: 278-332, Galactose oxidase, central domain

AA: 1005-1073, PDBID: 3OL2, Subunit B, Seq Identity:25%, Plexin repeat

AA: 1078-1114, PDBID: 1YO8, Subunit A, Seq Identity:34%, EGF domain

AA: 1163-1208, PDBID: 4AQT, Subunit A, Seq Identity:36%, Laminin EGF domain

AA: 1211-1261, PDBID: 1KLO, Subunit A, Seq Identity:36%, Laminin EGF domain

AA: 1509-1564, Galactose oxidase, central domain

AA: 2179-2232, PDBID: 4XL1, Subunit A, Seq Identity:30%, Calcium-binding EGF domain

AA: 2335-2378, PDBID: 1KLO, Subunit A, Seq Identity:28%, Laminin EGF domain

UniProt annotation for MEGF8_HUMAN » Multiple epidermal growth factor-like domains protein 8
DISEASE: Carpenter syndrome 2 (CRPT2) OMIM: An autosomal recessive multiple congenital malformation disorder characterized by multisuture craniosynostosis and polysyndactyly of the hands and feet, in association with abnormal left-right patterning and other features, most commonly obesity, umbilical hernia, cryptorchidism, and congenital heart disease. mutations affecting the gene represented in this entry.
UniProt features for MEGF8_HUMAN » Multiple epidermal growth factor-like domains protein 8
SIGNAL 1 27 Potential.
CHAIN 28 2845 Multiple epidermal growth factor-like domains protein 8.
DOMAIN 30 140 CUB 1.
DOMAIN 138 168 EGF-like 1.
DOMAIN 170 203 EGF-like 2.
REPEAT 241 287 Kelch 1.
REPEAT 290 338 Kelch 2.
REPEAT 346 399 Kelch 3.
REPEAT 402 453 Kelch 4.
REPEAT 459 511 Kelch 5.
REPEAT 525 575 Kelch 6.
DOMAIN 561 613 PSI 1.
DOMAIN 847 899 PSI 2.
DOMAIN 900 947 PSI 3.
DOMAIN 1074 1115 EGF-like 3; calcium-binding (Potential).
DOMAIN 1163 1210 Laminin EGF-like 1.
DOMAIN 1211 1261 Laminin EGF-like 2.
DOMAIN 1263 1405 CUB 2.
DOMAIN 1403 1445 EGF-like 4.
REPEAT 1522 1570 Kelch 7.
REPEAT 1580 1626 Kelch 8.
REPEAT 1632 1679 Kelch 9.
REPEAT 1685 1735 Kelch 10.
REPEAT 1796 1843 Kelch 11.
REPEAT 1852 1898 Kelch 12.
DOMAIN 1876 1916 PSI 4.
DOMAIN 1924 1979 PSI 5.
DOMAIN 2060 2118 PSI 6.
DOMAIN 2120 2177 PSI 7.
DOMAIN 2178 2216 EGF-like 5.
DOMAIN 2253 2301 Laminin EGF-like 3.
DOMAIN 2380 2443 Laminin EGF-like 4.
DISULFID 30 57 By similarity.
DISULFID 142 152 By similarity.
DISULFID 146 158 By similarity.
DISULFID 174 184 By similarity.
DISULFID 178 191 By similarity.
DISULFID 193 202 By similarity.
DISULFID 1078 1091 By similarity.
DISULFID 1085 1100 By similarity.
DISULFID 1102 1114 By similarity.
DISULFID 1163 1171 By similarity.
DISULFID 1165 1179 By similarity.
DISULFID 1182 1191 By similarity.
DISULFID 1194 1208 By similarity.
DISULFID 1211 1224 By similarity.
DISULFID 1213 1231 By similarity.
DISULFID 1233 1242 By similarity.
DISULFID 1245 1259 By similarity.
DISULFID 1263 1302 By similarity.
DISULFID 1336 1367 By similarity.
DISULFID 1407 1421 By similarity.
DISULFID 1415 1433 By similarity.
DISULFID 1435 1444 By similarity.
DISULFID 2182 2195 By similarity.
DISULFID 2189 2204 By similarity.
DISULFID 2253 2261 By similarity.
DISULFID 2255 2270 By similarity.
DISULFID 2273 2282 By similarity.
DISULFID 2285 2299 By similarity.
DISULFID 2380 2389 By similarity.
DISULFID 2382 2397 By similarity.
DISULFID 2399 2424 By similarity.
DISULFID 2427 2441 By similarity.
Amino Acid Sequence for MEGF8_HUMAN » Multiple epidermal growth factor-like domains protein 8
MALGKVLAMA LVLALAVLGS LSPGARAGDC KGQRQVLREA PGFVTDGAGN YSVNGNCEWL IEAPSPQHRI LLDFLFLDTE CTYDYLFVYD GDSPRGPLLA SLSGSTRPPP IEASSGKMLL HLFSDANYNL LGFNASFRFS LCPGGCQSHG QCQPPGVCAC EPGWGGPDCG LQECSAYCGS HGTCASPLGP CRCEPGFLGR ACDLHLWENQ GAGWWHNVSA RDPAFSARIG AAGAFLSPPG LLAVFGGQDL NNALGDLVLY NFSANTWESW DLSPAPAARH SHVAVAWAGS LVLMGGELAD GSLTNDVWAF SPLGRGHWEL LAPPASSSSG PPGLAGHAAA LVDDVWLYVS GGRTPHDLFS SGLFRFRLDS TSGGYWEQVI PAGGRPPAAT GHSMVFHAPS RALLVHGGHR PSTARFSVRV NSTELFHVDR HVWTTLKGRD GLQGPRERAF HTASVLGNYM VVYGGNVHTH YQEEKCYEDG IFFYHLGCHQ WVSGAELAPP GTPEGRAAPP SGRYSHVAAV LGGSVLLVAG GYSGRPRGDL MAYKVPPFVF QAPAPDYHLD YCSMYTDHSV CSRDPECSWC QGACQAAPPP GTPLGACPAA SCLGLGRLLG DCQACLAFSS PTAPPRGPGT LGWCVHNESC LPRPEQARCR GEQISGTVGW WGPAPVFVTS LEACVTQSFL PGLHLLTFQQ PPNTSQPDKV SIVRSTTITL TPSAETDVSL VYRGFIYPML PGGPGGPGAE DVAVWTRAQR LHVLARMARG PDTENMEEVG RWVAHQEKET RRLQRPGSAR LFPLPGRDHK YAVEIQGQLN GSAGPGHSEL TLLWDRTGVP GGSEISFFFL EPYRSSSCTS YSSCLGCLAD QGCGWCLTSA TCHLRQGGAH CGDDGAGGSL LVLVPTLCPL CEEHRDCHAC TQDPFCEWHQ STSRKGDAAC SRRGRGRGAL KSPEECPPLC SQRLTCEDCL ANSSQCAWCQ STHTCFLFAA YLARYPHGGC RGWDDSVHSE PRCRSCDGFL TCHECLQSHE CGWCGNEDNP TLGRCLQGDF SGPLGGGNCS LWVGEGLGLP VALPARWAYA RCPDVDECRL GLARCHPRAT CLNTPLSYEC HCQRGYQGDG ISHCNRTCLE DCGHGVCSGP PDFTCVCDLG WTSDLPPPTP APGPPAPRCS RDCGCSFHSH CRKRGPGFCD ECQDWTWGEH CERCRPGSFG NATGSRGCRP CQCNGHGDPR RGHCDNLSGL CFCQDHTEGA HCQLCSPGYY GDPRAGGSCF RECGGRALLT NVSSVALGSR RVGGLLPPGG GAARAGPGLS YCVWVVSATE ELQPCAPGTL CPPLTLTFSP DSSTPCTLSY VLAFDGFPRF LDTGVVQSDR SLIAAFCGQR RDRPLTVQAL SGLLVLHWEA NGSSSWGFNA SVGSARCGSG GPGSCPVPQE CVPQDGAAGA GLCRCPQGWA GPHCRMALCP ENCNAHTGAG TCNQSLGVCI CAEGFGGPDC ATKLDGGQLV WETLMDSRLS ADTASRFLHR LGHTMVDGPD ATLWMFGGLG LPQGLLGNLY RYSVSERRWT QMLAGAEDGG PGPSPRSFHA AAYVPAGRGA MYLLGGLTAG GVTRDFWVLN LTTLQWRQEK APQTVELPAV AGHTLTARRG LSLLLVGGYS PENGFNQQLL EYQLATGTWV SGAQSGTPPT GLYGHSAVYH EATDSLYVFG GFRFHVELAA PSPELYSLHC PDRTWSLLAP SQGAKRDRMR NVRGSSRGLG QVPGEQPGSW GFREVRKKMA LWAALAGTGG FLEEISPHLK EPRPRLFHAS ALLGDTMVVL GGRSDPDEFS SDVLLYQVNC NAWLLPDLTR SASVGPPMEE SVAHAVAAVG SRLYISGGFG GVALGRLLAL TLPPDPCRLL SSPEACNQSG ACTWCHGACL SGDQAHRLGC GGSPCSPMPR SPEECRRLRT CSECLARHPR TLQPGDGEAS TPRCKWCTNC PEGACIGRNG SCTSENDCRI NQREVFWAGN CSEAACGAAD CEQCTREGKC MWTRQFKRTG ETRRILSVQP TYDWTCFSHS LLNVSPMPVE SSPPLPCPTP CHLLPNCTSC LDSKGADGGW QHCVWSSSLQ QCLSPSYLPL RCMAGGCGRL LRGPESCSLG CAQATQCALC LRRPHCGWCA WGGQDGGGRC MEGGLSGPRD GLTCGRPGAS WAFLSCPPED ECANGHHDCN ETQNCHDQPH GYECSCKTGY TMDNMTGLCR PVCAQGCVNG SCVEPDHCRC HFGFVGRNCS TECRCNRHSE CAGVGARDHC LLCRNHTKGS HCEQCLPLFV GSAVGGGTCR PCHAFCRGNS HICISRKELQ MSKGEPKKYS LDPEEIENWV TEGPSEDEAV CVNCQNNSYG EKCESCLQGY FLLDGKCTKC QCNGHADTCN EQDGTGCPCQ NNTETGTCQG SSPSDRRDCY KYQCAKCRES FHGSPLGGQQ CYRLISVEQE CCLDPTSQTN CFHEPKRRAL GPGRTVLFGV QPKFTNVDIR LTLDVTFGAV DLYVSTSYDT FVVRVAPDTG VHTVHIQPPP APPPPPPPAD GGPRGAGDPG GAGASSGPGA PAEPRVREVW PRGLITYVTV TEPSAVLVVR GVRDRLVITY PHEHHALKSS RFYLLLLGVG DPSGPGANGS ADSQGLLFFR QDQAHIDLFV FFSVFFSCFF LFLSLCVLLW KAKQALDQRQ EQRRHLQEMT KMASRPFAKV TVCFPPDPTA PASAWKPAGL PPPAFRRSEP FLAPLLLTGA GGPWGPMGGG CCPPAIPATT AGLRAGPITL EPTEDGMAGV ATLLLQLPGG PHAPNGACLG SALVTLRHRL HEYCGGGGGA GGSGHGTGAG RKGLLSQDNL TSMSL