MEG11_HUMAN » Multiple epidermal growth factor-like domains protein 11

MEG11_HUMAN » Multiple epidermal growth factor-like domains protein 11
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MEG11_HUMAN » Multiple epidermal growth factor-like domains protein 11 » Multiple EGF-like domains protein 11;
Hydrophobic Thickness 34.8 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -57.3 kcal/mol
ΔGfold -25.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 848-872 (844-875)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 189-232, PDBID: 1KLO, Subunit A, Seq Identity:38%, Laminin EGF domain

AA: 234-253, PDBID: 2YGQ, Subunit A, Seq Identity:65%, Human growth factor-like EGF

AA: 275-320, PDBID: 1KLO, Subunit A, Seq Identity:33%, Laminin EGF domain

AA: 313-359, PDBID: 4OVE, Subunit A, Seq Identity:37%, Laminin EGF domain

AA: 361-409, PDBID: 1KLO, Subunit A, Seq Identity:38%, Laminin EGF domain

AA: 452-471, PDBID: 2YGQ, Subunit A, Seq Identity:56%, Human growth factor-like EGF

AA: 579-622, PDBID: 1KLO, Subunit A, Seq Identity:39%, Laminin EGF domain

AA: 618-666, PDBID: 4OVE, Subunit A, Seq Identity:35%, Laminin EGF domain

AA: 667-708, PDBID: 4WNX, Subunit A, Seq Identity:38%, Laminin EGF domain

AA: 712-731, PDBID: 2YGQ, Subunit A, Seq Identity:52%, Human growth factor-like EGF

AA: 753-796, PDBID: 1KLO, Subunit A, Seq Identity:43%, Laminin EGF domain

AA: 796-832, PDBID: 4OVE, Subunit A, Seq Identity:32%, Laminin EGF domain

UniProt annotation for MEG11_HUMAN » Multiple epidermal growth factor-like domains protein 11
FUNCTION: May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).

SUBUNIT: Homopolymer (Probable). Does not interact with MEGF10.

UniProt features for MEG11_HUMAN » Multiple epidermal growth factor-like domains protein 11
SIGNAL 1 19 Potential.
CHAIN 20 1044 Multiple epidermal growth factor-like domains protein 11.
DOMAIN 24 101 EMI.
DOMAIN 95 130 EGF-like 1.
DOMAIN 143 173 EGF-like 2.
DOMAIN 181 216 EGF-like 3.
DOMAIN 224 259 EGF-like 4.
DOMAIN 267 302 EGF-like 5.
DOMAIN 310 345 EGF-like 6.
DOMAIN 399 434 EGF-like 7.
DOMAIN 442 477 EGF-like 8.
DOMAIN 490 520 EGF-like 9.
DOMAIN 571 606 EGF-like 10.
DOMAIN 659 694 EGF-like 11.
DOMAIN 707 737 EGF-like 12.
DOMAIN 750 780 EGF-like 13.
DOMAIN 788 823 EGF-like 14.
DISULFID 28 89 Potential.
DISULFID 54 63 Potential.
DISULFID 88 99 Potential.
DISULFID 103 118 By similarity.
DISULFID 120 129 By similarity.
DISULFID 146 154 By similarity.
DISULFID 148 161 By similarity.
DISULFID 163 172 By similarity.
DISULFID 185 197 By similarity.
DISULFID 191 204 By similarity.
DISULFID 206 215 By similarity.
DISULFID 228 240 By similarity.
DISULFID 234 247 By similarity.
DISULFID 249 258 By similarity.
DISULFID 271 283 By similarity.
DISULFID 277 290 By similarity.
DISULFID 292 301 By similarity.
DISULFID 314 326 By similarity.
DISULFID 320 333 By similarity.
DISULFID 335 344 By similarity.
DISULFID 403 415 By similarity.
DISULFID 409 422 By similarity.
DISULFID 424 433 By similarity.
DISULFID 446 458 By similarity.
DISULFID 452 465 By similarity.
DISULFID 467 476 By similarity.
DISULFID 493 501 By similarity.
DISULFID 495 508 By similarity.
DISULFID 510 519 By similarity.
DISULFID 575 587 By similarity.
DISULFID 581 594 By similarity.
DISULFID 596 605 By similarity.
DISULFID 663 675 By similarity.
DISULFID 669 682 By similarity.
DISULFID 684 693 By similarity.
DISULFID 710 718 By similarity.
DISULFID 712 725 By similarity.
DISULFID 727 736 By similarity.
DISULFID 753 761 By similarity.
DISULFID 755 768 By similarity.
DISULFID 770 779 By similarity.
DISULFID 792 804 By similarity.
DISULFID 798 811 By similarity.
DISULFID 813 822 By similarity.
Amino Acid Sequence for MEG11_HUMAN » Multiple epidermal growth factor-like domains protein 11
MVLSLTGLIA FSFLQATLAL NPEDPNVCSH WESYAVTVQE SYAHPFDQIY YTRCTDILNW FKCTRHRISY KTAYRRGLRT MYRRRSQCCP GYYESGDFCI PLCTEECVHG RCVSPDTCHC EPGWGGPDCS SGCDSDHWGP HCSNRCQCQN GALCNPITGA CVCAAGFRGW RCEELCAPGT HGKGCQLPCQ CRHGASCDPR AGECLCAPGY TGVYCEELCP PGSHGAHCEL RCPCQNGGTC HHITGECACP PGWTGAVCAQ PCPPGTFGQN CSQDCPCHHG GQCDHVTGQC HCTAGYMGDR CQEECPFGSF GFQCSQHCDC HNGGQCSPTT GACECEPGYK GPRCQERLCP EGLHGPGCTL PCPCDADNTI SCHPVTGACT CQPGWSGHHC NESCPVGYYG DGCQLPCTCQ NGADCHSITG GCTCAPGFMG EVCAVSCAAG TYGPNCSSIC SCNNGGTCSP VDGSCTCKEG WQGLDCTLPC PSGTWGLNCN ESCTCANGAA CSPIDGSCSC TPGWLGDTCE LPCPDGTFGL NCSEHCDCSH ADGCDPVTGH CCCLAGWTGI RCDSTCPPGR WGPNCSVSCS CENGGSCSPE DGSCECAPGF RGPLCQRICP PGFYGHGCAQ PCPLCVHSSR PCHHISGICE CLPGFSGALC NQVCAGGYFG QDCAQLCSCA NNGTCSPIDG SCQCFPGWIG KDCSQACPPG FWGPACFHAC SCHNGASCSA EDGACHCTPG WTGLFCTQRC PAAFFGKDCG RVCQCQNGAS CDHISGKCTC RTGFTGQHCE QRCAPGTFGY GCQQLCECMN NSTCDHVTGT CYCSPGFKGI RCDQAALMME ELNPYTKISP ALGAERHSVG AVTGIMLLLF LIVVLLGLFA WHRRRQKEKG RDLAPRVSYT PAMRMTSTDY SLSGACGMDR RQNTYIMDKG FKDYMKESVC SSSTCSLNSS ENPYATIKDP PILTCKLPES SYVEMKSPVH MGSPYTDVPS LSTSNKNIYE VEPTVSVVQE GCGHNSSYIQ NAYDLPRNSH IPGHYDLLPV RQSPANGPSQ DKQS