MARCO_HUMAN » Macrophage receptor MARCO

MARCO_HUMAN » Macrophage receptor MARCO
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MARCO_HUMAN » Macrophage receptor MARCO » Macrophage receptor with collagenous structure;Scavenger receptor class A member 2;
Hydrophobic Thickness 34.0 ± 3.4 Å
Tilt Angle 22 ± 10°
ΔGtransfer -25.9 kcal/mol
ΔGfold -19.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 44-68 (44-74)
Pathways

Phagosome (KEGG)

PDB none
OPM none
Complexes

MARCO:MARCO_MOUSE

Interactions

MARCO, Complex: Homodimer of macrophage receptor MARCO, PDBID: 2OYA

Domains

AA: 140-205, PDBID: 2JG8, Subunit B, Seq Identity:40%, Collagen triple helix repeat (20 copies)

AA: 361-423, PDBID: 1M7L, Subunit A, Seq Identity:49%, Collagen triple helix repeat (20 copies)

AA: 427-519, PDBID: 2OY3, Subunit A, Seq Identity:68%, Scavenger receptor cysteine-rich domain

UniProt annotation for MARCO_HUMAN » Macrophage receptor MARCO
FUNCTION: Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.

SUBUNIT: Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands (By similarity).

UniProt features for MARCO_HUMAN » Macrophage receptor MARCO
CHAIN 1 520 Macrophage receptor MARCO.
DOMAIN 147 419 Collagen-like.
DOMAIN 424 519 SRCR.
DISULFID 447 508
DISULFID 460 518
DISULFID 488 498
Amino Acid Sequence for MARCO_HUMAN » Macrophage receptor MARCO
MRNKKILKED ELLSETQQAA FHQIAMEPFE INVPKPKRRN GVNFSLAVVV IYLILLTAGA GLLVVQVLNL QARLRVLEMY FLNDTLAAED SPSFSLLQSA HPGEHLAQGA SRLQVLQAQL TWVRVSHEHL LQRVDNFTQN PGMFRIKGEQ GAPGLQGHKG AMGMPGAPGP PGPPAEKGAK GAMGRDGATG PSGPQGPPGV KGEAGLQGPQ GAPGKQGATG TPGPQGEKGS KGDGGLIGPK GETGTKGEKG DLGLPGSKGD RGMKGDAGVM GPPGAQGSKG DFGRPGPPGL AGFPGAKGDQ GQPGLQGVPG PPGAVGHPGA KGEPGSAGSP GRAGLPGSPG SPGATGLKGS KGDTGLQGQQ GRKGESGVPG PAGVKGEQGS PGLAGPKGAP GQAGQKGDQG VKGSSGEQGV KGEKGERGEN SVSVRIVGSS NRGRAEVYYS GTWGTICDDE WQNSDAIVFC RMLGYSKGRA LYKVGAGTGQ IWLDNVQCRG TESTLWSCTK NSWGHHDCSH EEDAGVECSV