MAR1_HUMAN » Melanoma antigen recognized by T-cells 1

MAR1_HUMAN » Melanoma antigen recognized by T-cells 1
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Topology in Melanosome membrane
Topologymelanosome lumenal side
cytoplasmic side
MAR1_HUMAN » Melanoma antigen recognized by T-cells 1 » MART-1; Antigen LB39-AA;Antigen SK29-AA;Protein Melan-A;
Hydrophobic Thickness 34.4 ± 2.5 Å
Tilt Angle 2 ± 1°
ΔGtransfer -21.1 kcal/mol
ΔGfold -17.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 26-48 (24-51)
Pathways none
PDB 4euq (26-35), 2gt9 (C/F=26-35), 2gtw (C/F=27-35), 2gtz (C/F=27-35), 2guo (C/F=27-35), 4eup (C/F=27-35), 3qfd (C/F=27-35), 3l6f (C=100-114), 4qok (C=26-35), 4l3e (C=26-35), 4jff (C=26-35), 3qdm (C=26-35), 3hg1 (C=26-35), 3qeq (C=27-35), 3mrq (P=26-35), 3mrp (P=26-35), 3mro (P=26-35)
OPM none
Complexes

TCA:TRBC1:MAR1:1A02:B2MG_HUMAN

Q8WLS4:TCA:TRBC1:MAR1:B2MG_HUMAN

DRA:2B11:MAR1_HUMAN

MAR1:1A02:B2MG_HUMAN

Interactions

1A02, Complex: 1A02:B2MG:MAR1, PDBID: 2gt9

2B11, Complex: DRA:2B11:MAR1, PDBID: 3L6F

TCA, Complex: Q8WLS4:TCA:TRBC1:MAR1:B2MG, PDBID: 3HG1

Domains

AA: 2-118, PDBID: 2GT9, Subunit F, Seq Identity:100%, Protein melan-A

UniProt annotation for MAR1_HUMAN » Melanoma antigen recognized by T-cells 1
FUNCTION: Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

SUBUNIT: Interacts with PMEL. Interacts with GPR143.

TISSUE SPECIFICITY: Expression is restricted to melanoma and melanocyte cell lines and retina.

UniProt features for MAR1_HUMAN » Melanoma antigen recognized by T-cells 1
CHAIN 1 118 Melanoma antigen recognized by T-cells 1.
Amino Acid Sequence for MAR1_HUMAN » Melanoma antigen recognized by T-cells 1
MPREDAHFIY GYPKKGHGHS YTTAEEAAGI GILTVILGVL LLIGCWYCRR RNGYRALMDK SLHVGTQCAL TRRCPQEGFD HRDSKVSLQE KNCEPVVPNA PPAYEKLSAE QSPPPYSP