MAG_HUMAN » Myelin-associated glycoprotein

MAG_HUMAN » Myelin-associated glycoprotein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MAG_HUMAN » Myelin-associated glycoprotein » Siglec-4a;
Hydrophobic Thickness 26.0 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -34.1 kcal/mol
ΔGfold -17.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 514-535 (514-539)
Pathways

Cell adhesion molecules (KEGG)

Hemostasis (Reactome)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

A4, Complex: A4:MAG, PubMed

APRIO, Complex: APRIO.PRIO:MAG, PubMed

TNR16, Complex: TNR16:MAG, PubMed

Domains

AA: 140-226, PDBID: 4OFY, Subunit F, Seq Identity:25%, CD80-like C2-set immunoglobulin domain

AA: 239-309, PDBID: 2OM5, Subunit A, Seq Identity:35%, Immunoglobulin domain

AA: 328-396, PDBID: 1CS6, Subunit A, Seq Identity:33%, Immunoglobulin domain

UniProt annotation for MAG_HUMAN » Myelin-associated glycoprotein
FUNCTION: Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3- linked sialic acid (By similarity).

SUBUNIT: Binds to RTN4R.

UniProt features for MAG_HUMAN » Myelin-associated glycoprotein
SIGNAL 1 19
CHAIN 20 626 Myelin-associated glycoprotein.
DOMAIN 22 120 Ig-like V-type.
DOMAIN 139 237 Ig-like C2-type 1.
DOMAIN 241 325 Ig-like C2-type 2.
DOMAIN 327 412 Ig-like C2-type 3.
DOMAIN 413 508 Ig-like C2-type 4.
SITE 332 332 Not glycosylated.
DISULFID 37 165 By similarity.
DISULFID 42 100 By similarity.
DISULFID 159 217 By similarity.
DISULFID 261 305 By similarity.
DISULFID 347 392 By similarity.
DISULFID 421 430 By similarity.
DISULFID 432 488 By similarity.
Amino Acid Sequence for MAG_HUMAN » Myelin-associated glycoprotein
MIFLTALPLF WIMISASRGG HWGAWMPSSI SAFEGTCVSI PCRFDFPDEL RPAVVHGVWY FNSPYPKNYP PVVFKSRTQV VHESFQGRSR LLGDLGLRNC TLLLSNVSPE LGGKYYFRGD LGGYNQYTFS EHSVLDIVNT PNIVVPPEVV AGTEVEVSCM VPDNCPELRP ELSWLGHEGL GEPAVLGRLR EDEGTWVQVS LLHFVPTREA NGHRLGCQAS FPNTTLQFEG YASMDVKYPP VIVEMNSSVE AIEGSHVSLL CGADSNPPPL LTWMRDGTVL REAVAESLLL ELEEVTPAED GVYACLAENA YGQDNRTVGL SVMYAPWKPT VNGTMVAVEG ETVSILCSTQ SNPDPILTIF KEKQILSTVI YESELQLELP AVSPEDDGEY WCVAENQYGQ RATAFNLSVE FAPVLLLESH CAAARDTVQC LCVVKSNPEP SVAFELPSRN VTVNESEREF VYSERSGLVL TSILTLRGQA QAPPRVICTA RNLYGAKSLE LPFQGAHRLM WAKIGPVGAV VAFAILIAIV CYITQTRRKK NVTESPSFSA GDNPPVLFSS DFRISGAPEK YESERRLGSE RRLLGLRGEP PELDLSYSHS DLGKRPTKDS YTLTEELAEY AEIRVK