MADCA_HUMAN » Mucosal addressin cell adhesion molecule 1

MADCA_HUMAN » Mucosal addressin cell adhesion molecule 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
MADCA_HUMAN » Mucosal addressin cell adhesion molecule 1 » MAdCAM-1; hMAdCAM-1;
Hydrophobic Thickness 28.0 ± 2.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -29.6 kcal/mol
ΔGfold -14.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 321-343 (319-346)
Pathways

Cell adhesion molecules (KEGG)

Immune System (Reactome)

Intestinal immune network for IgA production (KEGG)

Signal Transduction (Reactome)

PDB 1gsm (19-224), 4hd9 (23-225), 1bqs (23-231), 4hbq (A/B=23-171, A/B=180-224), 4hc1 (A/B=23-171, A/B=180-224), 4hcr (A/B=23-225)
OPM none
Complexes none
Interactions

CD44, Complex: CD44:MADCA, PubMed

ITA4, Complex: ITA4:MADCA, PubMed

ITB7, Complex: ITB7:MADCA, PubMed

MADCA, Complex: Homodimer of mucosal addressin cell adhesion molecule 1, PDBID: 4HBQ

Domains

AA: 113-224, PDBID: 1BQS, Subunit A, Seq Identity:100%, Adhesion molecule, immunoglobulin-like

UniProt annotation for MADCA_HUMAN » Mucosal addressin cell adhesion molecule 1
FUNCTION: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding.

SUBUNIT: Homodimer.

TISSUE SPECIFICITY: Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.

UniProt features for MADCA_HUMAN » Mucosal addressin cell adhesion molecule 1
SIGNAL 1 18 Potential.
CHAIN 19 382 Mucosal addressin cell adhesion molecule 1.
DOMAIN 23 112 Ig-like 1.
DOMAIN 113 231 Ig-like 2.
REPEAT 228 231 1; truncated.
REPEAT 232 239 2.
REPEAT 240 247 3.
REPEAT 248 255 4.
REPEAT 256 263 5.
REPEAT 264 271 6.
REGION 226 317 Mucin-like.
REGION 228 271 5.5 X 8 AA tandem repeats of [PS]-P-D-T- T-S-[QP]-E.
DISULFID 47 94
DISULFID 51 98
DISULFID 134 204
Amino Acid Sequence for MADCA_HUMAN » Mucosal addressin cell adhesion molecule 1
MDFGLALLLA GLLGLLLGQS LQVKPLQVEP PEPVVAVALG ASRQLTCRLA CADRGASVQW RGLDTSLGAV QSDTGRSVLT VRNASLSAAG TRVCVGSCGG RTFQHTVQLL VYAFPDQLTV SPAALVPGDP EVACTAHKVT PVDPNALSFS LLVGGQELEG AQALGPEVQE EEEEPQGDED VLFRVTERWR LPPLGTPVPP ALYCQATMRL PGLELSHRQA IPVLHSPTSP EPPDTTSPES PDTTSPESPD TTSQEPPDTT SPEPPDKTSP EPAPQQGSTH TPRSPGSTRT RRPEISQAGP TQGEVIPTGS SKPAGDQLPA ALWTSSAVLG LLLLALPTYH LWKRCRHLAE DDTHPPASLR LLPQVSAWAG LRGTGQVGIS PS