LYVE1_HUMAN » Lymphatic vessel endothelial hyaluronic acid receptor 1

LYVE1_HUMAN » Lymphatic vessel endothelial hyaluronic acid receptor 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LYVE1_HUMAN » Lymphatic vessel endothelial hyaluronic acid receptor 1 » LYVE-1; Cell surface retention sequence-binding protein 1;CRSBP-1; Extracellular link domain-containing protein 1;Hyaluronic acid receptor;
Hydrophobic Thickness 32.0 ± 1.2 Å
Tilt Angle 5 ± 3°
ΔGtransfer -42.1 kcal/mol
ΔGfold -17.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 236-260 (236-262)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 41-129, PDBID: 1POZ, Subunit A, Seq Identity:32%, Extracellular link domain

UniProt annotation for LYVE1_HUMAN » Lymphatic vessel endothelial hyaluronic acid receptor 1
FUNCTION: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

SUBUNIT: Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN (By similarity).

TISSUE SPECIFICITY: Mainly expressed in endothelial cells lining lymphatic vessels.

UniProt features for LYVE1_HUMAN » Lymphatic vessel endothelial hyaluronic acid receptor 1
SIGNAL 1 19 Potential.
CHAIN 20 322 Lymphatic vessel endothelial hyaluronic acid receptor 1.
DOMAIN 40 130 Link.
DISULFID 61 128 By similarity.
DISULFID 85 106 By similarity.
Amino Acid Sequence for LYVE1_HUMAN » Lymphatic vessel endothelial hyaluronic acid receptor 1
MARCFSLVLL LTSIWTTRLL VQGSLRAEEL SIQVSCRIMG ITLVSKKANQ QLNFTEAKEA CRLLGLSLAG KDQVETALKA SFETCSYGWV GDGFVVISRI SPNPKCGKNG VGVLIWKVPV SRQFAAYCYN SSDTWTNSCI PEIITTKDPI FNTQTATQTT EFIVSDSTYS VASPYSTIPA PTTTPPAPAS TSIPRRKKLI CVTEVFMETS TMSTETEPFV ENKAAFKNEA AGFGGVPTAL LVLALLFFGA AAGLGFCYVK RYVKAFPFTN KNQQKEMIET KVVKEEKAND SNPNEESKKT DKNPEESKSP SKTTVRCLEA EV