LYK4_ARATH » LysM domain receptor-like kinase 4

LYK4_ARATH » LysM domain receptor-like kinase 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LYK4_ARATH » LysM domain receptor-like kinase 4 » LysM-containing receptor-like kinase 4;
Hydrophobic Thickness 34.0 ± 3.4 Å
Tilt Angle 38 ± 8°
ΔGtransfer -19.7 kcal/mol
ΔGfold -19.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 271-299 (262-299)
Pathways none
PDB none
OPM none
Complexes none
Interactions

Y5241, Complex: Y5241:LYK4

Domains

AA: 121-166, PDBID: 4S3K, Subunit A, Seq Identity:36%, LysM domain

AA: 188-232, PDBID: 4S3K, Subunit A, Seq Identity:38%, LysM domain

AA: 370-597, PDBID: 4L68, Subunit B, Seq Identity:45%, Protein tyrosine kinase

UniProt annotation for LYK4_ARATH » LysM domain receptor-like kinase 4
FUNCTION: Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity. Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands. Involved in the resistance to the pathogenic fungus Alternaria brassicicola and to the bacterial pathogen the bacterial pathogen Pseudomonas syringae pv tomato DC3000, probably by sensing microbe-associated molecular pattern (MAMP) and pathogen-associated molecular patterns (PAMP). May play a role in detecting peptidoglycans (e.g. PGNs) during bacterial growth.

CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

SUBUNIT: Homooligomer (By similarity). Binds to chitin oligosaccharide elicitors.

TISSUE SPECIFICITY: Expressed in roots, stems, leaves (predominantly in hydathodes, apical meristems and stipules) and buds.

INDUCTION: Moderately induced by chitin oligomers (e.g. chitohexaose (6-mer) and chitooctaose (8-mer)) and flagellin (e.g. flg22).

UniProt features for LYK4_ARATH » LysM domain receptor-like kinase 4
SIGNAL 1 22 Potential.
CHAIN 23 612 LysM domain receptor-like kinase 4.
REPEAT 121 166 LysM 1.
REPEAT 188 232 LysM 2.
DOMAIN 283 601 Protein kinase.
REGION 125 131 Chitin-binding (By similarity).
REGION 154 160 Chitin-binding (By similarity).
ACT_SITE 467 467 Proton acceptor (By similarity).
DISULFID 48 110 By similarity.
DISULFID 55 171 By similarity.
DISULFID 108 169 By similarity.
Amino Acid Sequence for LYK4_ARATH » LysM domain receptor-like kinase 4
MISFSFHLLV FILLSLSSFA TAQQPYVGIS TTDCSVSDNT TSVFGYSCNG LNKTCQAYVI FRSTPSFSTV TSISSLFSVD PSLVSSLNDA SPSTSFPSGQ QVIIPLTCSC TGDDSQSNIT YTIQPNDSYF AIANDTLQGL STCQALAKQN NVSSQSLFPG MRIVVPIRCA CPTAKQINED GVKYLMSYTV VFEDTIAIIS DRFGVETSKT LKANEMSFEN SEVFPFTTIL IPLVNPPANT NSLIPPPPPP PPQSVSPPPL SPDGRKSKKK TWVYALAGVL GGALVLSVIG AAIFCLSKKK TKTQTQEETG NLDSFMGKKP PMSDQEFDPL DGLSGMVVES LKVYKFHELQ SATSDFTSSS SIGGSGYIGK INGDGAMIKK IEGNASEEVN LLSKLNHLNI IRLSGFCFHE GDWYLVYEHA SNGSLSEWIH TTKSLLSLTQ KLQIALDIAT GLNYLHNFAD PPYVHRDLNS NNVFLDLEFR AKIGSLGSAR STTEDFVLTK HVEGTRGYLA PEYLEHGLVS TKLDVYAFGV VLLEIVTGKE ASELKKEIDE GKAIDEILIH GRLLPEGLTS FVERLVVDCL KKDHLNRPSM DENVMSLSKI LAATQNWEES SY