LYAM3_HUMAN » P-selectin

LYAM3_HUMAN » P-selectin
Magnify LYAM3_HUMAN » P-selectinEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LYAM3_HUMAN » P-selectin » CD62 antigen-like family member P;Granule membrane protein 140;GMP-140; Leukocyte-endothelial cell adhesion molecule 3;LECAM3; Platelet activation dependent granule-external membrane protein;PADGEM;
Hydrophobic Thickness 33.2 ± 2.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -34.0 kcal/mol
ΔGfold -11.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 770-795 (768-797)
Pathways

Cell adhesion molecules (KEGG)

Hemostasis (Reactome)

Malaria (KEGG)

Staphylococcus aureus infection (KEGG)

PDB 1fsb (160-199), 1g1q (A/B/C/D=42-198), 1g1r (A/B/C/D=42-198), 1g1s (A/B=42-198), 1hes (P=813-830)
OPM none
Complexes

SELPL:LYAM3_HUMAN

LYAM3:LYAM3_HUMAN

Interactions

FUT4, Complex: LYAM3:FUT4, PubMed

GP1BA, Complex: GP1BA:LYAM3, PubMed

GP1BA, Complex: LYAM3:GP1BA, PubMed

LYAM3, Complex: Homodimer of P-selectin, PDBID: 1G1Q

SELPL, Complex: LYAM3:SELPL, PDBID: 1g1s, PubMed

Domains

AA: 49-160, PDBID: 1G1Q, Subunit C, Seq Identity:100%, Lectin C-type domain

AA: 200-257, PDBID: 4C16, Subunit A, Seq Identity:47%, Sushi repeat (SCR repeat)

AA: 262-319, PDBID: 4C16, Subunit A, Seq Identity:44%, Sushi repeat (SCR repeat)

AA: 324-381, PDBID: 4C16, Subunit A, Seq Identity:45%, Sushi repeat (SCR repeat)

AA: 386-443, PDBID: 4C16, Subunit A, Seq Identity:42%, Sushi repeat (SCR repeat)

AA: 448-505, PDBID: 4C16, Subunit A, Seq Identity:38%, Sushi repeat (SCR repeat)

AA: 510-567, PDBID: 4C16, Subunit A, Seq Identity:45%, Sushi repeat (SCR repeat)

AA: 572-629, PDBID: 4C16, Subunit A, Seq Identity:44%, Sushi repeat (SCR repeat)

AA: 642-699, PDBID: 4C16, Subunit A, Seq Identity:45%, Sushi repeat (SCR repeat)

AA: 704-761, PDBID: 1SRZ, Subunit A, Seq Identity:35%, Sushi repeat (SCR repeat)

UniProt annotation for LYAM3_HUMAN » P-selectin
FUNCTION: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

SUBUNIT: Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.

TISSUE SPECIFICITY: Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

DISEASE: Ischemic stroke (ISCHSTR) OMIM: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. susceptibility is associated with variations affecting the gene represented in this entry.

UniProt features for LYAM3_HUMAN » P-selectin
SIGNAL 1 41
CHAIN 42 830 P-selectin.
DOMAIN 58 158 C-type lectin.
DOMAIN 159 195 EGF-like.
DOMAIN 198 259 Sushi 1.
DOMAIN 260 321 Sushi 2.
DOMAIN 322 383 Sushi 3.
DOMAIN 384 445 Sushi 4.
DOMAIN 446 507 Sushi 5.
DOMAIN 508 569 Sushi 6.
DOMAIN 570 631 Sushi 7.
DOMAIN 640 701 Sushi 8.
DOMAIN 702 763 Sushi 9.
REGION 821 830 Interaction with SNX17.
MOTIF 818 821 Endocytosis signal (Probable).
DISULFID 60 158 By similarity.
DISULFID 131 150 By similarity.
DISULFID 163 174
DISULFID 168 183
DISULFID 185 194
DISULFID 200 244 By similarity.
DISULFID 230 257 By similarity.
DISULFID 262 306 By similarity.
DISULFID 292 319 By similarity.
DISULFID 324 368 By similarity.
DISULFID 354 381 By similarity.
DISULFID 386 430 By similarity.
DISULFID 416 443 By similarity.
DISULFID 448 492 By similarity.
DISULFID 478 505 By similarity.
DISULFID 510 554 By similarity.
DISULFID 540 567 By similarity.
DISULFID 572 616 By similarity.
DISULFID 602 629 By similarity.
DISULFID 642 686 By similarity.
DISULFID 672 699 By similarity.
DISULFID 704 748 By similarity.
DISULFID 734 761 By similarity.
Amino Acid Sequence for LYAM3_HUMAN » P-selectin
MANCQIAILY QRFQRVVFGI SQLLCFSALI SELTNQKEVA AWTYHYSTKA YSWNISRKYC QNRYTDLVAI QNKNEIDYLN KVLPYYSSYY WIGIRKNNKT WTWVGTKKAL TNEAENWADN EPNNKRNNED CVEIYIKSPS APGKWNDEHC LKKKHALCYT ASCQDMSCSK QGECLETIGN YTCSCYPGFY GPECEYVREC GELELPQHVL MNCSHPLGNF SFNSQCSFHC TDGYQVNGPS KLECLASGIW TNKPPQCLAA QCPPLKIPER GNMTCLHSAK AFQHQSSCSF SCEEGFALVG PEVVQCTASG VWTAPAPVCK AVQCQHLEAP SEGTMDCVHP LTAFAYGSSC KFECQPGYRV RGLDMLRCID SGHWSAPLPT CEAISCEPLE SPVHGSMDCS PSLRAFQYDT NCSFRCAEGF MLRGADIVRC DNLGQWTAPA PVCQALQCQD LPVPNEARVN CSHPFGAFRY QSVCSFTCNE GLLLVGASVL QCLATGNWNS VPPECQAIPC TPLLSPQNGT MTCVQPLGSS SYKSTCQFIC DEGYSLSGPE RLDCTRSGRW TDSPPMCEAI KCPELFAPEQ GSLDCSDTRG EFNVGSTCHF SCDNGFKLEG PNNVECTTSG RWSATPPTCK GIASLPTPGL QCPALTTPGQ GTMYCRHHPG TFGFNTTCYF GCNAGFTLIG DSTLSCRPSG QWTAVTPACR AVKCSELHVN KPIAMNCSNL WGNFSYGSIC SFHCLEGQLL NGSAQTACQE NGHWSTTVPT CQAGPLTIQE ALTYFGGAVA STIGLIMGGT LLALLRKRFR QKDDGKCPLN PHSHLGTYGV FTNAAFDPSP