LYAM2_HUMAN » E-selectin

LYAM2_HUMAN » E-selectin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LYAM2_HUMAN » E-selectin » CD62 antigen-like family member E;Endothelial leukocyte adhesion molecule 1;ELAM-1; Leukocyte-endothelial cell adhesion molecule 2;LECAM2;
Hydrophobic Thickness 34.4 ± 2.6 Å
Tilt Angle 14 ± 12°
ΔGtransfer -19.1 kcal/mol
ΔGfold -12.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 557-582 (555-586)
Pathways

African trypanosomiasis (KEGG)

Cell adhesion molecules (KEGG)

Malaria (KEGG)

TNF signaling pathway (KEGG)

PDB 1g1t (22-178), 1esl (22-183), 4c16 (22-301), 4csy (22-301)
OPM none
Complexes none
Interactions

CD44, Complex: LYAM2:CD44, PubMed

GSLG1, Complex: LYAM2:GSLG1, PubMed

LYAM1, Complex: LYAM1:LYAM2, PubMed

MUC18, Complex: MUC18:LYAM2, PubMed

PODXL, Complex: PODXL:LYAM2, PubMed

SELPL, Complex: SELPL:LYAM2, PubMed

Domains

AA: 29-140, PDBID: 1ESL, Subunit A, Seq Identity:100%, Lectin C-type domain

AA: 143-173, PDBID: 1ESL, Subunit A, Seq Identity:100%, EGF-like domain

AA: 180-237, PDBID: 4C16, Subunit A, Seq Identity:100%, Sushi repeat (SCR repeat)

AA: 242-299, PDBID: 4C16, Subunit A, Seq Identity:100%, Sushi repeat (SCR repeat)

AA: 304-362, PDBID: 4C16, Subunit A, Seq Identity:43%, Sushi repeat (SCR repeat)

AA: 367-425, PDBID: 4C16, Subunit A, Seq Identity:50%, Sushi repeat (SCR repeat)

AA: 430-488, PDBID: 4C16, Subunit A, Seq Identity:50%, Sushi repeat (SCR repeat)

AA: 493-547, PDBID: 1SRZ, Subunit A, Seq Identity:39%, Sushi repeat (SCR repeat)

UniProt annotation for LYAM2_HUMAN » E-selectin
FUNCTION: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

SUBUNIT: Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.

UniProt features for LYAM2_HUMAN » E-selectin
SIGNAL 1 21
CHAIN 22 610 E-selectin.
DOMAIN 22 139 C-type lectin.
DOMAIN 140 175 EGF-like.
DOMAIN 178 239 Sushi 1.
DOMAIN 240 301 Sushi 2.
DOMAIN 303 364 Sushi 3.
DOMAIN 366 427 Sushi 4.
DOMAIN 429 490 Sushi 5.
DOMAIN 491 549 Sushi 6.
DISULFID 40 138
DISULFID 111 130
DISULFID 143 154
DISULFID 148 163
DISULFID 165 174
DISULFID 180 224 By similarity.
DISULFID 210 237 By similarity.
DISULFID 242 286 By similarity.
DISULFID 272 299 By similarity.
DISULFID 304 349 By similarity.
DISULFID 335 362 By similarity.
DISULFID 367 412 By similarity.
DISULFID 398 425 By similarity.
DISULFID 430 475 By similarity.
DISULFID 461 488 By similarity.
DISULFID 493 534 By similarity.
DISULFID 520 547 By similarity.
Amino Acid Sequence for LYAM2_HUMAN » E-selectin
MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI QNKEEIEYLN SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG EPNNRQKDED CVEIYIKREK DVGMWNDERC SKKKLALCYT AACTNTSCSG HGECVETINN YTCKCDPGFS GLKCEQIVNC TALESPEHGS LVCSHPLGNF SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV ECDAVTNPAN GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT TQGQWTQQIP VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ GFVLKGSKRL QCGPTGEWDN EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE FTYKSSCAFS CEEGFELHGS TQLECTSQGQ WTEEVPSCQV VKCSSLAVPG KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW SGLLPTCEAP TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD GSYQKPSYIL