LYAM1_HUMAN » L-selectin

LYAM1_HUMAN » L-selectin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LYAM1_HUMAN » L-selectin » Lymph node homing receptor;Leukocyte adhesion molecule 1;LAM-1; Leukocyte surface antigen Leu-8;TQ1;gp90-MEL;Leukocyte-endothelial cell adhesion molecule 1;LECAM1; CD62 antigen-like family member L;
Hydrophobic Thickness 34.0 ± 1.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -50.8 kcal/mol
ΔGfold -16.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 333-358 (333-362)
Pathways

Cell adhesion molecules (KEGG)

Hemostasis (Reactome)

Immune System (Reactome)

PDB 3cfw (39-194), 2lgf (B=349-363)
OPM none
Complexes none
Interactions

CD4, Complex: CD4:LYAM1, PubMed

LYAM2, Complex: LYAM1:LYAM2, PubMed

MUCEN, Complex: LYAM1:MUCEN, PubMed

PDXL2, Complex: LYAM1:PDXL2, PubMed

PODXL, Complex: PODXL:LYAM1, PubMed

SELPL, Complex: LYAM1:SELPL, PubMed

Domains

AA: 46-157, PDBID: 3CFW, Subunit A, Seq Identity:100%, Lectin C-type domain

AA: 197-254, PDBID: 4C16, Subunit A, Seq Identity:47%, Sushi repeat (SCR repeat)

AA: 259-316, PDBID: 4C16, Subunit A, Seq Identity:42%, Sushi repeat (SCR repeat)

UniProt annotation for LYAM1_HUMAN » L-selectin
FUNCTION: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.

SUBUNIT: Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on "Tyr-51" of PSGL1 is important for L-selectin binding.

TISSUE SPECIFICITY: Expressed in B-cell lines and T-lymphocytes.

UniProt features for LYAM1_HUMAN » L-selectin
SIGNAL 1 28
PROPEP 29 38
CHAIN 39 372 L-selectin.
DOMAIN 55 155 C-type lectin.
DOMAIN 156 192 EGF-like.
DOMAIN 195 256 Sushi 1.
DOMAIN 257 318 Sushi 2.
DISULFID 57 155 By similarity.
DISULFID 128 147 By similarity.
DISULFID 160 171 By similarity.
DISULFID 165 180 By similarity.
DISULFID 182 191 By similarity.
DISULFID 197 241 By similarity.
DISULFID 227 254 By similarity.
DISULFID 259 303 By similarity.
DISULFID 289 316 By similarity.
Amino Acid Sequence for LYAM1_HUMAN » L-selectin
MIFPWKCQST QRDLWNIFKL WGWTMLCCDF LAHHGTDCWT YHYSEKPMNW QRARRFCRDN YTDLVAIQNK AEIEYLEKTL PFSRSYYWIG IRKIGGIWTW VGTNKSLTEE AENWGDGEPN NKKNKEDCVE IYIKRNKDAG KWNDDACHKL KAALCYTASC QPWSCSGHGE CVEIINNYTC NCDVGYYGPQ CQFVIQCEPL EAPELGTMDC THPLGNFSFS SQCAFSCSEG TNLTGIEETT CGPFGNWSSP EPTCQVIQCE PLSAPDLGIM NCSHPLASFS FTSACTFICS EGTELIGKKK TICESSGIWS NPSPICQKLD KSFSMIKEGD YNPLFIPVAV MVTAFSGLAF IIWLARRLKK GKKSKRSMND PY