LY75_HUMAN » Lymphocyte antigen 75

LY75_HUMAN » Lymphocyte antigen 75
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LY75_HUMAN » Lymphocyte antigen 75 » Ly-75; C-type lectin domain family 13 member B;DEC-205;gp200-MR6;
Hydrophobic Thickness 36.0 ± 2.8 Å
Tilt Angle 40 ± 13°
ΔGtransfer -28.4 kcal/mol
ΔGfold -25.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1665-1694 (1665-1696)
Pathways none
PDB none
OPM none
Complexes none
Interactions

FATE1, Complex: LY75:FATE1

Domains

AA: 169-209, PDBID: 1CK7, Subunit A, Seq Identity:46%, Fibronectin type II domain

AA: 236-342, PDBID: 5AO5, Subunit A, Seq Identity:46%, Lectin C-type domain

AA: 378-487, PDBID: 5AO5, Subunit A, Seq Identity:30%, Lectin C-type domain

AA: 525-625, PDBID: 5AO5, Subunit A, Seq Identity:22%, Lectin C-type domain

AA: 667-792, PDBID: 3VYJ, Subunit A, Seq Identity:24%, Lectin C-type domain

AA: 830-932, PDBID: 2KV3, Subunit A, Seq Identity:26%, Lectin C-type domain

AA: 969-1091, PDBID: 2M94, Subunit A, Seq Identity:25%, Lectin C-type domain

AA: 1120-1222, PDBID: 1T8C, Subunit A, Seq Identity:35%, Lectin C-type domain

AA: 1267-1360, PDBID: 4IOP, Subunit A, Seq Identity:37%, Lectin C-type domain

AA: 1411-1513, PDBID: 5AO5, Subunit A, Seq Identity:34%, Lectin C-type domain

AA: 1552-1661, PDBID: 1LIT, Subunit A, Seq Identity:31%, Lectin C-type domain

UniProt annotation for LY75_HUMAN » Lymphocyte antigen 75
FUNCTION: Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

TISSUE SPECIFICITY: Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B-lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.

MISCELLANEOUS: Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.

UniProt features for LY75_HUMAN » Lymphocyte antigen 75
SIGNAL 1 27
CHAIN 28 1722 Lymphocyte antigen 75.
DOMAIN 33 156 Ricin B-type lectin.
DOMAIN 164 211 Fibronectin type-II.
DOMAIN 225 341 C-type lectin 1.
DOMAIN 368 486 C-type lectin 2.
DOMAIN 493 625 C-type lectin 3.
DOMAIN 652 778 C-type lectin 4.
DOMAIN 818 931 C-type lectin 5.
DOMAIN 958 1091 C-type lectin 6.
DOMAIN 1110 1222 C-type lectin 7.
DOMAIN 1251 1374 C-type lectin 8.
DOMAIN 1401 1513 C-type lectin 9.
DOMAIN 1542 1661 C-type lectin 10.
DISULFID 169 194 By similarity.
DISULFID 183 209 By similarity.
DISULFID 247 340 By similarity.
DISULFID 317 332 By similarity.
DISULFID 389 485 By similarity.
DISULFID 462 477 By similarity.
DISULFID 597 614 By similarity.
DISULFID 840 930 By similarity.
DISULFID 904 922 By similarity.
DISULFID 1060 1080 By similarity.
DISULFID 1197 1211 By similarity.
DISULFID 1488 1502 By similarity.
DISULFID 1635 1650 By similarity.
Amino Acid Sequence for LY75_HUMAN » Lymphocyte antigen 75
MRTGWATPRR PAGLLMLLFW FFDLAEPSGR AANDPFTIVH GNTGKCIKPV YGWIVADDCD ETEDKLWKWV SQHRLFHLHS QKCLGLDITK SVNELRMFSC DSSAMLWWKC EHHSLYGAAR YRLALKDGHG TAISNASDVW KKGGSEESLC DQPYHEIYTR DGNSYGRPCE FPFLIDGTWH HDCILDEDHS GPWCATTLNY EYDRKWGICL KPENGCEDNW EKNEQFGSCY QFNTQTALSW KEAYVSCQNQ GADLLSINSA AELTYLKEKE GIAKIFWIGL NQLYSARGWE WSDHKPLNFL NWDPDRPSAP TIGGSSCARM DAESGLWQSF SCEAQLPYVC RKPLNNTVEL TDVWTYSDTR CDAGWLPNNG FCYLLVNESN SWDKAHAKCK AFSSDLISIH SLADVEVVVT KLHNEDIKEE VWIGLKNINI PTLFQWSDGT EVTLTYWDEN EPNVPYNKTP NCVSYLGELG QWKVQSCEEK LKYVCKRKGE KLNDASSDKM CPPDEGWKRH GETCYKIYED EVPFGTNCNL TITSRFEQEY LNDLMKKYDK SLRKYFWTGL RDVDSCGEYN WATVGGRRRA VTFSNWNFLE PASPGGCVAM STGKSVGKWE VKDCRSFKAL SICKKMSGPL GPEEASPKPD DPCPEGWQSF PASLSCYKVF HAERIVRKRN WEEAERFCQA LGAHLSSFSH VDEIKEFLHF LTDQFSGQHW LWIGLNKRSP DLQGSWQWSD RTPVSTIIMP NEFQQDYDIR DCAAVKVFHR PWRRGWHFYD DREFIYLRPF ACDTKLEWVC QIPKGRTPKT PDWYNPDRAG IHGPPLIIEG SEYWFVADLH LNYEEAVLYC ASNHSFLATI TSFVGLKAIK NKIANISGDG QKWWIRISEW PIDDHFTYSR YPWHRFPVTF GEECLYMSAK TWLIDLGKPT DCSTKLPFIC EKYNVSSLEK YSPDSAAKVQ CSEQWIPFQN KCFLKIKPVS LTFSQASDTC HSYGGTLPSV LSQIEQDFIT SLLPDMEATL WIGLRWTAYE KINKWTDNRE LTYSNFHPLL VSGRLRIPEN FFEEESRYHC ALILNLQKSP FTGTWNFTSC SERHFVSLCQ KYSEVKSRQT LQNASETVKY LNNLYKIIPK TLTWHSAKRE CLKSNMQLVS ITDPYQQAFL SVQALLHNSS LWIGLFSQDD ELNFGWSDGK RLHFSRWAET NGQLEDCVVL DTDGFWKTVD CNDNQPGAIC YYSGNETEKE VKPVDSVKCP SPVLNTPWIP FQNCCYNFII TKNRHMATTQ DEVHTKCQKL NPKSHILSIR DEKENNFVLE QLLYFNYMAS WVMLGITYRN NSLMWFDKTP LSYTHWRAGR PTIKNEKFLA GLSTDGFWDI QTFKVIEEAV YFHQHSILAC KIEMVDYKEE YNTTLPQFMP YEDGIYSVIQ KKVTWYEALN MCSQSGGHLA SVHNQNGQLF LEDIVKRDGF PLWVGLSSHD GSESSFEWSD GSTFDYIPWK GQTSPGNCVL LDPKGTWKHE KCNSVKDGAI CYKPTKSKKL SRLTYSSRCP AAKENGSRWI QYKGHCYKSD QALHSFSEAK KLCSKHDHSA TIVSIKDEDE NKFVSRLMRE NNNITMRVWL GLSQHSVDQS WSWLDGSEVT FVKWENKSKS GVGRCSMLIA SNETWKKVEC EHGFGRVVCK VPLGPDYTAI AIIVATLSIL VLMGGLIWFL FQRHRLHLAG FSSVRYAQGV NEDEIMLPSF HD