LY66F_HUMAN » Lymphocyte antigen 6 complex locus protein G6f

LY66F_HUMAN » Lymphocyte antigen 6 complex locus protein G6f
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LY66F_HUMAN » Lymphocyte antigen 6 complex locus protein G6f »
Hydrophobic Thickness 38.8 ± 1.8 Å
Tilt Angle 2 ± 2°
ΔGtransfer -41.1 kcal/mol
ΔGfold -18.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 232-259 (232-262)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 19-126, PDBID: 2BNQ, Subunit D, Seq Identity:28%, Immunoglobulin V-set domain

UniProt annotation for LY66F_HUMAN » Lymphocyte antigen 6 complex locus protein G6f
FUNCTION: May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.

SUBUNIT: Homodimer; disulfide-linked. Interacts with GRB2 and GRB7 in a phosphorylation-dependent manner.

UniProt features for LY66F_HUMAN » Lymphocyte antigen 6 complex locus protein G6f
SIGNAL 1 16 Potential.
CHAIN 17 297 Lymphocyte antigen 6 complex locus protein G6f.
DOMAIN 17 122 Ig-like V-type.
DISULFID 35 106 By similarity.
Amino Acid Sequence for LY66F_HUMAN » Lymphocyte antigen 6 complex locus protein G6f
MAVLFLLLFL CGTPQAADNM QAIYVALGEA VELPCPSPPT LHGDEHLSWF CSPAAGSFTT LVAQVQVGRP APDPGKPGRE SRLRLLGNYS LWLEGSKEED AGRYWCAVLG QHHNYQNWRV YDVLVLKGSQ LSARAADGSP CNVLLCSVVP SRRMDSVTWQ EGKGPVRGRV QSFWGSEAAL LLVCPGEGLS EPRSRRPRII RCLMTHNKGV SFSLAASIDA SPALCAPSTG WDMPWILMLL LTMGQGVVIL ALSIVLWRQR VRGAPGRDAS IPQFKPEIQV YENIHLARLG PPAHKPR