LST1_HUMAN » Leukocyte-specific transcript 1 protein

LST1_HUMAN » Leukocyte-specific transcript 1 protein
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
LST1_HUMAN » Leukocyte-specific transcript 1 protein » Protein B144;
Hydrophobic Thickness 30.8 ± 2.6 Å
Tilt Angle 43 ± 36°
ΔGtransfer -20.4 kcal/mol
ΔGfold -18.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 10-38 (6-42)
Pathways none
PDB none
OPM none
Complexes none
Interactions

NTAL, Complex: LST1:NTAL:CD81:CD9, PubMed

Domains

AA: 16-96, LST-1 protein

UniProt annotation for LST1_HUMAN » Leukocyte-specific transcript 1 protein
FUNCTION: Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.

TISSUE SPECIFICITY: Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain.

INDUCTION: By IFNG/IFN-gamma. Up-regulated upon autoimmune and bacterially-induced inflammation.

UniProt features for LST1_HUMAN » Leukocyte-specific transcript 1 protein
CHAIN 1 97 Leukocyte-specific transcript 1 protein.
Amino Acid Sequence for LST1_HUMAN » Leukocyte-specific transcript 1 protein
MLSRNDDICI YGGLGLGGLL LLAVVLLSAC LCWLHRRVKR LERSWAQGSS EQELHYASLQ RLPVPSSEGP DLRGRDKRGT KEDPRADYAC IAENKPT