LRRT4_HUMAN » Leucine-rich repeat transmembrane neuronal protein 4

LRRT4_HUMAN » Leucine-rich repeat transmembrane neuronal protein 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRRT4_HUMAN » Leucine-rich repeat transmembrane neuronal protein 4 »
Hydrophobic Thickness 34.4 ± 2.6 Å
Tilt Angle 12 ± 8°
ΔGtransfer -24.2 kcal/mol
ΔGfold -21.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 422-446 (420-450)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 64-121, PDBID: 4Z0C, Subunit D, Seq Identity:45%, Leucine rich repeat

AA: 109-167, PDBID: 4Z0C, Subunit D, Seq Identity:43%, Leucine rich repeat

AA: 133-193, PDBID: 2XOT, Subunit A, Seq Identity:41%, Leucine rich repeat

AA: 157-217, PDBID: 1OZN, Subunit A, Seq Identity:39%, Leucine rich repeat

AA: 229-289, PDBID: 4BSR, Subunit B, Seq Identity:41%, Leucine rich repeat

UniProt annotation for LRRT4_HUMAN » Leucine-rich repeat transmembrane neuronal protein 4
FUNCTION: May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity).

SUBUNIT: Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including LRRTM4. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity).

TISSUE SPECIFICITY: Expressed in neuronal tissues.

UniProt features for LRRT4_HUMAN » Leucine-rich repeat transmembrane neuronal protein 4
SIGNAL 1 30 Potential.
CHAIN 31 590 Leucine-rich repeat transmembrane neuronal protein 4.
DOMAIN 31 61 LRRNT.
REPEAT 62 83 LRR 1.
REPEAT 86 107 LRR 2.
REPEAT 110 131 LRR 3.
REPEAT 134 155 LRR 4.
REPEAT 158 179 LRR 5.
REPEAT 182 203 LRR 6.
REPEAT 206 226 LRR 7.
REPEAT 230 251 LRR 8.
REPEAT 254 275 LRR 9.
REPEAT 278 299 LRR 10.
DOMAIN 311 362 LRRCT.
Amino Acid Sequence for LRRT4_HUMAN » Leucine-rich repeat transmembrane neuronal protein 4
MGFHLITQLK GMSVVLVLLP TLLLVMLTGA QRACPKNCRC DGKIVYCESH AFADIPENIS GGSQGLSLRF NSIQKLKSNQ FAGLNQLIWL YLDHNYISSV DEDAFQGIRR LKELILSSNK ITYLHNKTFH PVPNLRNLDL SYNKLQTLQS EQFKGLRKLI ILHLRSNSLK TVPIRVFQDC RNLDFLDLGY NRLRSLSRNA FAGLLKLKEL HLEHNQFSKI NFAHFPRLFN LRSIYLQWNR IRSISQGLTW TWSSLHNLDL SGNDIQGIEP GTFKCLPNLQ KLNLDSNKLT NISQETVNAW ISLISITLSG NMWECSRSIC PLFYWLKNFK GNKESTMICA GPKHIQGEKV SDAVETYNIC SEVQVVNTER SHLVPQTPQK PLIIPRPTIF KPDVTQSTFE TPSPSPGFQI PGAEQEYEHV SFHKIIAGSV ALFLSVAMIL LVIYVSWKRY PASMKQLQQH SLMKRRRKKA RESERQMNSP LQEYYVDYKP TNSETMDISV NGSGPCTYTI SGSRECEMPH HMKPLPYYSY DQPVIGYCQA HQPLHVTKGY ETVSPEQDES PGLELGRDHS FIATIARSAA PAIYLERIAN