LRRT3_HUMAN » Leucine-rich repeat transmembrane neuronal protein 3

LRRT3_HUMAN » Leucine-rich repeat transmembrane neuronal protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRRT3_HUMAN » Leucine-rich repeat transmembrane neuronal protein 3 »
Hydrophobic Thickness 33.6 ± 2.8 Å
Tilt Angle 30 ± 6°
ΔGtransfer -24.7 kcal/mol
ΔGfold -22.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 417-442 (411-445)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 92-145, PDBID: 4Y61, Subunit B, Seq Identity:47%, Leucine rich repeat

AA: 133-193, PDBID: 2XOT, Subunit A, Seq Identity:40%, Leucine rich repeat

AA: 157-217, PDBID: 4U7L, Subunit A, Seq Identity:41%, Leucine rich repeat

AA: 181-241, PDBID: 4P8S, Subunit A, Seq Identity:51%, Leucine rich repeat

AA: 229-290, PDBID: 4LI1, Subunit A, Seq Identity:42%, Leucine rich repeat

UniProt annotation for LRRT3_HUMAN » Leucine-rich repeat transmembrane neuronal protein 3
FUNCTION: Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system.

TISSUE SPECIFICITY: Expressed in neuronal tissues.

UniProt features for LRRT3_HUMAN » Leucine-rich repeat transmembrane neuronal protein 3
SIGNAL 1 30 Potential.
CHAIN 31 581 Leucine-rich repeat transmembrane neuronal protein 3.
DOMAIN 31 61 LRRNT.
REPEAT 63 83 LRR 1.
REPEAT 86 107 LRR 2.
REPEAT 110 131 LRR 3.
REPEAT 134 155 LRR 4.
REPEAT 158 179 LRR 5.
REPEAT 182 203 LRR 6.
REPEAT 206 226 LRR 7.
REPEAT 230 251 LRR 8.
REPEAT 254 275 LRR 9.
REPEAT 279 300 LRR 10.
DOMAIN 312 363 LRRCT.
Amino Acid Sequence for LRRT3_HUMAN » Leucine-rich repeat transmembrane neuronal protein 3
MGFNVIRLLS GSAVALVIAP TVLLTMLSSA ERGCPKGCRC EGKMVYCESQ KLQEIPSSIS AGCLGLSLRY NSLQKLKYNQ FKGLNQLTWL YLDHNHISNI DENAFNGIRR LKELILSSNR ISYFLNNTFR PVTNLRNLDL SYNQLHSLGS EQFRGLRKLL SLHLRSNSLR TIPVRIFQDC RNLELLDLGY NRIRSLARNV FAGMIRLKEL HLEHNQFSKL NLALFPRLVS LQNLYLQWNK ISVIGQTMSW TWSSLQRLDL SGNEIEAFSG PSVFQCVPNL QRLNLDSNKL TFIGQEILDS WISLNDISLA GNIWECSRNI CSLVNWLKSF KGLRENTIIC ASPKELQGVN VIDAVKNYSI CGKSTTERFD LARALPKPTF KPKLPRPKHE SKPPLPPTVG ATEPGPETDA DAEHISFHKI IAGSVALFLS VLVILLVIYV SWKRYPASMK QLQQRSLMRR HRKKKRQSLK QMTPSTQEFY VDYKPTNTET SEMLLNGTGP CTYNKSGSRE CEIPLSMNVS TFLAYDQPTI SYCGVHHELL SHKSFETNAQ EDTMETHLET ELDLSTITTA GRISDHKQQL A