LRRT2_HUMAN » Leucine-rich repeat transmembrane neuronal protein 2

LRRT2_HUMAN » Leucine-rich repeat transmembrane neuronal protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRRT2_HUMAN » Leucine-rich repeat transmembrane neuronal protein 2 » Leucine-rich repeat neuronal 2 protein;
Hydrophobic Thickness 32.4 ± 1.4 Å
Tilt Angle 1 ± 2°
ΔGtransfer -49.0 kcal/mol
ΔGfold -22.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 419-444 (417-446)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 65-121, PDBID: 2ID5, Subunit D, Seq Identity:43%, Leucine rich repeat

AA: 133-193, PDBID: 4P8S, Subunit A, Seq Identity:43%, Leucine rich repeat

AA: 186-241, PDBID: 4P8S, Subunit A, Seq Identity:43%, Leucine rich repeat

AA: 253-312, PDBID: 2Z7X, Subunit A, Seq Identity:39%, Leucine rich repeat

UniProt annotation for LRRT2_HUMAN » Leucine-rich repeat transmembrane neuronal protein 2
FUNCTION: Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).

SUBUNIT: Interacts with DLG4 and NRXN1.

TISSUE SPECIFICITY: Expressed in neuronal tissues.

DOMAIN: Synaptogenic effects are mediated by the extracellular LRR region.

UniProt features for LRRT2_HUMAN » Leucine-rich repeat transmembrane neuronal protein 2
SIGNAL 1 33 Potential.
CHAIN 34 516 Leucine-rich repeat transmembrane neuronal protein 2.
DOMAIN 34 61 LRRNT.
REPEAT 63 83 LRR 1.
REPEAT 86 107 LRR 2.
REPEAT 110 131 LRR 3.
REPEAT 134 155 LRR 4.
REPEAT 158 179 LRR 5.
REPEAT 182 203 LRR 6.
REPEAT 206 227 LRR 7.
REPEAT 230 251 LRR 8.
REPEAT 254 275 LRR 9.
REPEAT 278 299 LRR 10.
DOMAIN 311 362 LRRCT.
MOTIF 513 516 Involved in DLG4-binding (By similarity).
Amino Acid Sequence for LRRT2_HUMAN » Leucine-rich repeat transmembrane neuronal protein 2
MGLHFKWPLG APMLAAIYAM SMVLKMLPAL GMACPPKCRC EKLLFYCDSQ GFHSVPNATD KGSLGLSLRH NHITELERDQ FASFSQLTWL HLDHNQISTV KEDAFQGLYK LKELILSSNK IFYLPNTTFT QLINLQNLDL SFNQLSSLHP ELFYGLRKLQ TLHLRSNSLR TIPVRLFWDC RSLEFLDLST NRLRSLARNG FAGLIKLREL HLEHNQLTKI NFAHFLRLSS LHTLFLQWNK ISNLTCGMEW TWGTLEKLDL TGNEIKAIDL TVFETMPNLK ILLMDNNKLN SLDSKILNSL RSLTTVGLSG NLWECSARIC ALASWLGSFQ GRWEHSILCH SPDHTQGEDI LDAVHGFQLC WNLSTTVTVM ATTYRDPTTE YTKRISSSSY HVGDKEIPTT AGIAVTTEEH FPEPDNAIFT QRVITGTMAL LFSFFFIIFI VFISRKCCPP TLRRIRQCSM VQNHRQLRSQ TRLHMSNMSD QGPYNEYEPT HEGPFIIING YGQCKCQQLP YKECEV