LRRT1_HUMAN » Leucine-rich repeat transmembrane neuronal protein 1

LRRT1_HUMAN » Leucine-rich repeat transmembrane neuronal protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRRT1_HUMAN » Leucine-rich repeat transmembrane neuronal protein 1 »
Hydrophobic Thickness 34.8 ± 1.8 Å
Tilt Angle 2 ± 1°
ΔGtransfer -26.3 kcal/mol
ΔGfold -21.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 428-450 (422-451)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 113-173, PDBID: 2V9S, Subunit C, Seq Identity:40%, Leucine rich repeat

AA: 161-221, PDBID: 2ID5, Subunit C, Seq Identity:37%, Leucine rich repeat

AA: 256-315, PDBID: 4LI1, Subunit A, Seq Identity:35%, Leucine rich repeat

UniProt annotation for LRRT1_HUMAN » Leucine-rich repeat transmembrane neuronal protein 1
FUNCTION: Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.

TISSUE SPECIFICITY: Predominantly expressed in forebrain regions including thalamus and cerebral cortex.

MISCELLANEOUS: This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated paternally with handedness and schizophrenia.

UniProt features for LRRT1_HUMAN » Leucine-rich repeat transmembrane neuronal protein 1
SIGNAL 1 34 Potential.
CHAIN 35 522 Leucine-rich repeat transmembrane neuronal protein 1.
DOMAIN 35 63 LRRNT.
REPEAT 64 87 LRR 1.
REPEAT 89 111 LRR 2.
REPEAT 112 135 LRR 3.
REPEAT 137 159 LRR 4.
REPEAT 161 183 LRR 5.
REPEAT 184 207 LRR 6.
REPEAT 209 231 LRR 7.
REPEAT 233 255 LRR 8.
REPEAT 256 278 LRR 9.
REPEAT 279 302 LRR 10.
DOMAIN 314 365 LRRCT.
Amino Acid Sequence for LRRT1_HUMAN » Leucine-rich repeat transmembrane neuronal protein 1
MDFLLLGLCL YWLLRRPSGV VLCLLGACFQ MLPAAPSGCP QLCRCEGRLL YCEALNLTEA PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH ICSVQGDAFQ KLRRVKELTL SSNQITQLPN TTFRPMPNLR SVDLSYNKLQ ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI FQDCRSLKFL DIGYNQLKSL ARNSFAGLFK LTELHLEHND LVKVNFAHFP RLISLHSLCL RRNKVAIVVS SLDWVWNLEK MDLSGNEIEY MEPHVFETVP HLQSLQLDSN RLTYIEPRIL NSWKSLTSIT LAGNLWDCGR NVCALASWLN NFQGRYDGNL QCASPEYAQG EDVLDAVYAF HLCEDGAEPT SGHLLSAVTN RSDLGPPASS ATTLADGGEG QHDGTFEPAT VALPGGEHAE NAVQIHKVVT GTMALIFSFL IVVLVLYVSW KCFPASLRQL RQCFVTQRRK QKQKQTMHQM AAMSAQEYYV DYKPNHIEGA LVIINEYGSC TCHQQPAREC EV