LRRN4_HUMAN » Leucine-rich repeat neuronal protein 4

LRRN4_HUMAN » Leucine-rich repeat neuronal protein 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRRN4_HUMAN » Leucine-rich repeat neuronal protein 4 » Neuronal leucine-rich repeat protein 4;NLRR-4;
Hydrophobic Thickness 37.6 ± 3.0 Å
Tilt Angle 3 ± 2°
ΔGtransfer -18.3 kcal/mol
ΔGfold -12.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 680-705 (678-708)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 122-182, PDBID: 2WFH, Subunit A, Seq Identity:39%, Leucine rich repeat

AA: 581-664, PDBID: 2DJU, Subunit A, Seq Identity:37%, Fibronectin type III domain

UniProt annotation for LRRN4_HUMAN » Leucine-rich repeat neuronal protein 4
FUNCTION: May play an important role in hippocampus-dependent long-lasting memory.
UniProt features for LRRN4_HUMAN » Leucine-rich repeat neuronal protein 4
SIGNAL 1 18 Potential.
CHAIN 19 740 Leucine-rich repeat neuronal protein 4.
REPEAT 51 74 LRR 1.
REPEAT 75 97 LRR 2.
REPEAT 98 123 LRR 3.
REPEAT 125 144 LRR 4.
REPEAT 145 168 LRR 5.
REPEAT 174 197 LRR 6.
REPEAT 203 226 LRR 7.
REPEAT 228 251 LRR 8.
REPEAT 253 276 LRR 9.
REPEAT 277 300 LRR 10.
DOMAIN 580 669 Fibronectin type-III.
Amino Acid Sequence for LRRN4_HUMAN » Leucine-rich repeat neuronal protein 4
MRQTLPLLLL TVLRPSWADP PQEKVPLFRV TQQGPWGSSG SNATDSPCEG LPAADATALT LANRNLERLP GCLPRTLRSL DASHNLLRAL STSELGHLEQ LQVLTLRHNR IAALRWGPGG PAGLHTLDLS YNQLAALPPC TGPALSSLRA LALAGNPLRA LQPRAFACFP ALQLLNLSCT ALGRGAQGGI AEAAFAGEDG APLVTLEVLD LSGTFLERVE SGWIRDLPKL TSLYLRKMPR LTTLEGDIFK MTPNLQQLDC QDSPALASVA THIFQDTPHL QVLLFQNCNL SSFPPWTLDS SQVLSINLFG NPLTCSCDLS WLLTDAKRTV LSRAADTMCA PAAGSSGPFS ASLSLSQLPG VCQSDQSTTL GASHPPCFNR STYAQGTTVA PSAAPATRPA GDQQSVSKAP NVGSRTIAAW PHSDAREGTA PSTTNSVAGH SNSSVFPRAA STTRTQHRGE HAPELVLEPD ISAASTPLAS KLLGPFPTSW DRSISSPQPG QRTHATPQAP NPSLSEGEIP VLLLDDYSEE EEGRKEEVGT PHQDVPCDYH PCKHLQTPCA ELQRRWRCRC PGLSGEDTIP DPPRLQGVTE TTDTSALVHW CAPNSVVHGY QIRYSAEGWA GNQSVVGVIY ATARQHPLYG LSPGTTYRVC VLAANRAGLS QPRSSGWRSP CAAFTTKPSF ALLLSGLCAA SGLLLASTVV LSACLCRRGQ TLGLQRCDTH LVAYKNPAFD DYPLGLQTVS