LRRN2_HUMAN » Leucine-rich repeat neuronal protein 2

LRRN2_HUMAN » Leucine-rich repeat neuronal protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRRN2_HUMAN » Leucine-rich repeat neuronal protein 2 » Glioma amplified on chromosome 1 protein;Leucine-rich repeat neuronal protein 5;
Hydrophobic Thickness 34.8 ± 2.2 Å
Tilt Angle 11 ± 10°
ΔGtransfer -22.1 kcal/mol
ΔGfold -18.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 627-650 (627-650)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 69-129, PDBID: 4CNC, Subunit B, Seq Identity:38%, Leucine rich repeat

AA: 93-153, PDBID: 4P8S, Subunit A, Seq Identity:45%, Leucine rich repeat

AA: 117-177, PDBID: 4U7L, Subunit A, Seq Identity:44%, Leucine rich repeat

AA: 213-273, PDBID: 4P8S, Subunit A, Seq Identity:41%, Leucine rich repeat

AA: 310-371, PDBID: 1OZN, Subunit A, Seq Identity:36%, Leucine rich repeat

AA: 427-514, PDBID: 2V9Q, Subunit A, Seq Identity:32%, Immunoglobulin I-set domain

UniProt annotation for LRRN2_HUMAN » Leucine-rich repeat neuronal protein 2
TISSUE SPECIFICITY: Overamplified in malignant gliomas.
UniProt features for LRRN2_HUMAN » Leucine-rich repeat neuronal protein 2
SIGNAL 1 18 Potential.
CHAIN 19 713 Leucine-rich repeat neuronal protein 2.
DOMAIN 20 69 LRRNT.
REPEAT 70 91 LRR 1.
REPEAT 94 115 LRR 2.
REPEAT 118 139 LRR 3.
REPEAT 142 163 LRR 4.
REPEAT 166 187 LRR 5.
REPEAT 190 211 LRR 6.
REPEAT 214 235 LRR 7.
REPEAT 238 259 LRR 8.
REPEAT 262 283 LRR 9.
REPEAT 286 305 LRR 10.
REPEAT 311 333 LRR 11.
REPEAT 336 357 LRR 12.
DOMAIN 369 422 LRRCT.
DOMAIN 422 511 Ig-like C2-type.
DISULFID 445 497 By similarity.
Amino Acid Sequence for LRRN2_HUMAN » Leucine-rich repeat neuronal protein 2
MRLLVAPLLL AWVAGATAAV PVVPWHVPCP PQCACQIRPW YTPRSSYREA TTVDCNDLFL TAVPPALPAG TQTLLLQSNS IVRVDQSELG YLANLTELDL SQNSFSDARD CDFHALPQLL SLHLEENQLT RLEDHSFAGL ASLQELYLNH NQLYRIAPRA FSGLSNLLRL HLNSNLLRAI DSRWFEMLPN LEILMIGGNK VDAILDMNFR PLANLRSLVL AGMNLREISD YALEGLQSLE SLSFYDNQLA RVPRRALEQV PGLKFLDLNK NPLQRVGPGD FANMLHLKEL GLNNMEELVS IDKFALVNLP ELTKLDITNN PRLSFIHPRA FHHLPQMETL MLNNNALSAL HQQTVESLPN LQEVGLHGNP IRCDCVIRWA NATGTRVRFI EPQSTLCAEP PDLQRLPVRE VPFREMTDHC LPLISPRSFP PSLQVASGES MVLHCRALAE PEPEIYWVTP AGLRLTPAHA GRRYRVYPEG TLELRRVTAE EAGLYTCVAQ NLVGADTKTV SVVVGRALLQ PGRDEGQGLE LRVQETHPYH ILLSWVTPPN TVSTNLTWSS ASSLRGQGAT ALARLPRGTH SYNITRLLQA TEYWACLQVA FADAHTQLAC VWARTKEATS CHRALGDRPG LIAILALAVL LLAAGLAAHL GTGQPRKGVG GRRPLPPAWA FWGWSAPSVR VVSAPLVLPW NPGRKLPRSS EGETLLPPLS QNS