LRRC4_HUMAN » Leucine-rich repeat-containing protein 4

LRRC4_HUMAN » Leucine-rich repeat-containing protein 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRRC4_HUMAN » Leucine-rich repeat-containing protein 4 » Brain tumor-associated protein BAG;Nasopharyngeal carcinoma-associated gene 14 protein;Netrin-G2 ligand;NGL-2;
Hydrophobic Thickness 36.0 ± 4.4 Å
Tilt Angle 30 ± 0°
ΔGtransfer -32.1 kcal/mol
ΔGfold -26.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 522-550 (521-553)
Pathways

Axon guidance (KEGG)

Cell adhesion molecules (KEGG)

PDB 2dl9 (353-442), 3zyi (A=1-444)
OPM none
Complexes none
Interactions none
Domains

AA: 75-135, PDBID: 3ZYI, Subunit A, Seq Identity:100%, Leucine rich repeat

AA: 125-178, PDBID: 3ZYI, Subunit A, Seq Identity:100%, Leucine rich repeat

AA: 147-208, PDBID: 4KT1, Subunit A, Seq Identity:39%, Leucine rich repeat

AA: 244-301, PDBID: 3ZYI, Subunit A, Seq Identity:100%, Leucine rich repeat

AA: 353-441, PDBID: 2DL9, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

UniProt annotation for LRRC4_HUMAN » Leucine-rich repeat-containing protein 4
FUNCTION: Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity).

SUBUNIT: Interacts with DLG4 (By similarity). Interacts (via LRR repeats) with NTNG2. Forms a complex with DLG4 and with NMDA receptors.

TISSUE SPECIFICITY: Specifically expressed in brain.

DOMAIN: The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4.

UniProt features for LRRC4_HUMAN » Leucine-rich repeat-containing protein 4
SIGNAL 1 38 Potential.
CHAIN 39 653 Leucine-rich repeat-containing protein 4.
DOMAIN 39 75 LRRNT.
REPEAT 76 97 LRR 1.
REPEAT 100 121 LRR 2.
REPEAT 124 145 LRR 3.
REPEAT 148 169 LRR 4.
REPEAT 172 194 LRR 5.
REPEAT 197 218 LRR 6.
REPEAT 219 240 LRR 7.
REPEAT 243 264 LRR 8.
REPEAT 267 288 LRR 9.
DOMAIN 300 352 LRRCT.
DOMAIN 353 442 Ig-like.
DISULFID 374 424 By similarity.
Amino Acid Sequence for LRRC4_HUMAN » Leucine-rich repeat-containing protein 4
MKLLWQVTVH HHTWNAILLP FVYLTAQVWI LCAAIAAAAS AGPQNCPSVC SCSNQFSKVV CTRRGLSEVP QGIPSNTRYL NLMENNIQMI QADTFRHLHH LEVLQLGRNS IRQIEVGAFN GLASLNTLEL FDNWLTVIPS GAFEYLSKLR ELWLRNNPIE SIPSYAFNRV PSLMRLDLGE LKKLEYISEG AFEGLFNLKY LNLGMCNIKD MPNLTPLVGL EELEMSGNHF PEIRPGSFHG LSSLKKLWVM NSQVSLIERN AFDGLASLVE LNLAHNNLSS LPHDLFTPLR YLVELHLHHN PWNCDCDILW LAWWLREYIP TNSTCCGRCH APMHMRGRYL VEVDQASFQC SAPFIMDAPR DLNISEGRMA ELKCRTPPMS SVKWLLPNGT VLSHASRHPR ISVLNDGTLN FSHVLLSDTG VYTCMVTNVA GNSNASAYLN VSTAELNTSN YSFFTTVTVE TTEISPEDTT RKYKPVPTTS TGYQPAYTTS TTVLIQTTRV PKQVAVPATD TTDKMQTSLD EVMKTTKIII GCFVAVTLLA AAMLIVFYKL RKRHQQRSTV TAARTVEIIQ VDEDIPAATS AAATAAPSGV SGEGAVVLPT IHDHINYNTY KPAHGAHWTE NSLGNSLHPT VTTISEPYII QTHTKDKVQE TQI