LRR70_HUMAN » Leucine-rich repeat-containing protein 70

LRR70_HUMAN » Leucine-rich repeat-containing protein 70
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
LRR70_HUMAN » Leucine-rich repeat-containing protein 70 » Synleurin;
Hydrophobic Thickness 36.0 ± 2.4 Å
Tilt Angle 29 ± 8°
ΔGtransfer -33.5 kcal/mol
ΔGfold -25.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 526-553 (526-559)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 61-120, PDBID: 1XCD, Subunit A, Seq Identity:38%, Leucine rich repeat

AA: 108-168, PDBID: 4P8S, Subunit A, Seq Identity:42%, Leucine rich repeat

AA: 158-216, PDBID: 3ZYN, Subunit A, Seq Identity:41%, Leucine rich repeat

AA: 181-240, PDBID: 4Z0C, Subunit D, Seq Identity:47%, Leucine rich repeat

AA: 205-264, PDBID: 3CIG, Subunit A, Seq Identity:46%, Leucine rich repeat

AA: 229-288, PDBID: 4U7L, Subunit A, Seq Identity:41%, Leucine rich repeat

AA: 256-312, PDBID: 4Y61, Subunit B, Seq Identity:43%, Leucine rich repeat

AA: 277-325, PDBID: 3B2D, Subunit A, Seq Identity:40%, Leucine rich repeat

AA: 300-360, PDBID: 2Z7X, Subunit A, Seq Identity:46%, Leucine rich repeat

UniProt annotation for LRR70_HUMAN » Leucine-rich repeat-containing protein 70
FUNCTION: Renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS).

TISSUE SPECIFICITY: Expressed at low levels in many tissues, including smooth muscle, brain, uterus, pancreas, cartilage, adipose, spleen and testis.

UniProt features for LRR70_HUMAN » Leucine-rich repeat-containing protein 70
SIGNAL 1 31 Potential.
CHAIN 32 622 Leucine-rich repeat-containing protein 70.
DOMAIN 32 60 LRRNT.
REPEAT 61 82 LRR 1.
REPEAT 85 106 LRR 2.
REPEAT 109 130 LRR 3.
REPEAT 133 154 LRR 4.
REPEAT 157 178 LRR 5.
REPEAT 181 202 LRR 6.
REPEAT 205 226 LRR 7.
REPEAT 229 250 LRR 8.
REPEAT 253 274 LRR 9.
REPEAT 277 298 LRR 10.
REPEAT 301 322 LRR 11.
REPEAT 326 347 LRR 12.
DOMAIN 359 406 LRRCT.
Amino Acid Sequence for LRR70_HUMAN » Leucine-rich repeat-containing protein 70
MCGLQFSLPC LRLFLVVTCY LLLLLHKEIL GCSSVCQLCT GRQINCRNLG LSSIPKNFPE STVFLYLTGN NISYINESEL TGLHSLVALY LDNSNILYVY PKAFVQLRHL YFLFLNNNFI KRLDPGIFKG LLNLRNLYLQ YNQVSFVPRG VFNDLVSVQY LNLQRNRLTV LGSGTFVGMV ALRILDLSNN NILRISESGF QHLENLACLY LGSNNLTKVP SNAFEVLKSL RRLSLSHNPI EAIQPFAFKG LANLEYLLLK NSRIRNVTRD GFSGINNLKH LILSHNDLEN LNSDTFSLLK NLIYLKLDRN RIISIDNDTF ENMGASLKIL NLSFNNLTAL HPRVLKPLSS LIHLQANSNP WECNCKLLGL RDWLASSAIT LNIYCQNPPS MRGRALRYIN ITNCVTSSIN VSRAWAVVKS PHIHHKTTAL MMAWHKVTTN GSPLENTETE NITFWERIPT SPAGRFFQEN AFGNPLETTA VLPVQIQLTT SVTLNLEKNS ALPNDAASMS GKTSLICTQE VEKLNEAFDI LLAFFILACV LIIFLIYKVV QFKQKLKASE NSRENRLEYY SFYQSARYNV TASICNTSPN SLESPGLEQI RLHKQIVPEN EAQVILFEHS AL